JP2025511331A - Ｍｃｉ－１アンタゴニストの非晶質及び結晶性形態 - Google Patents

Ｍｃｉ－１アンタゴニストの非晶質及び結晶性形態 Download PDF

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JP2025511331A
JP2025511331A JP2024558382A JP2024558382A JP2025511331A JP 2025511331 A JP2025511331 A JP 2025511331A JP 2024558382 A JP2024558382 A JP 2024558382A JP 2024558382 A JP2024558382 A JP 2024558382A JP 2025511331 A JP2025511331 A JP 2025511331A
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crystalline form
amg
amorphous
crystalline
amg176
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Japanese (ja)
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JP2025511331A5 (enExample
Inventor
リュウ，ヨスプ
ルー，バン
ザンカネラ，マニュエル
チャベス，メアリー
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アムジエン・インコーポレーテツド
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Publication of JP2025511331A publication Critical patent/JP2025511331A/ja
Publication of JP2025511331A5 publication Critical patent/JP2025511331A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2024558382A 2022-04-05 2023-04-05 Ｍｃｉ－１アンタゴニストの非晶質及び結晶性形態 Pending JP2025511331A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263327656P 2022-04-05 2022-04-05
US63/327,656 2022-04-05
PCT/US2023/017505 WO2023196361A1 (en) 2022-04-05 2023-04-05 Amorphous and crystalline forms of mci-1 antagonists

Publications (2)

Publication Number Publication Date
JP2025511331A true JP2025511331A (ja) 2025-04-15
JP2025511331A5 JP2025511331A5 (enExample) 2026-04-10

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ID=86386948

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JP2024558382A Pending JP2025511331A (ja) 2022-04-05 2023-04-05 Ｍｃｉ－１アンタゴニストの非晶質及び結晶性形態

Country Status (9)

Country Link
US (1) US20240140966A1 (enExample)
EP (1) EP4504738A1 (enExample)
JP (1) JP2025511331A (enExample)
AU (1) AU2023250874A1 (enExample)
CA (1) CA3255077A1 (enExample)
MX (1) MX2024012195A (enExample)
TW (1) TW202404982A (enExample)
UY (1) UY40218A (enExample)
WO (1) WO2023196361A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4519271A1 (en) 2022-05-04 2025-03-12 Gilead Sciences, Inc. Salts and polymorphs of certain mcl-1 inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3474B1 (ar) 2014-08-29 2020-07-05 Amgen Inc مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1
KR20230113577A (ko) * 2020-11-25 2023-07-31 암젠 인크 알데히드의 거울상이성질체 선택적 알케닐화

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Publication number Publication date
US20240140966A1 (en) 2024-05-02
CA3255077A1 (en) 2023-10-12
TW202404982A (zh) 2024-02-01
WO2023196361A1 (en) 2023-10-12
MX2024012195A (es) 2024-11-08
EP4504738A1 (en) 2025-02-12
AU2023250874A1 (en) 2024-10-10
UY40218A (es) 2023-10-13

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