JP2025503945A - Ｙａｐ／ｔｅａｄ調節およびそれらの適応症のための化合物および方法 - Google Patents

Ｙａｐ／ｔｅａｄ調節およびそれらの適応症のための化合物および方法 Download PDF

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JP2025503945A
JP2025503945A JP2024543955A JP2024543955A JP2025503945A JP 2025503945 A JP2025503945 A JP 2025503945A JP 2024543955 A JP2024543955 A JP 2024543955A JP 2024543955 A JP2024543955 A JP 2024543955A JP 2025503945 A JP2025503945 A JP 2025503945A
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optionally substituted
cycloalkyl
heterocycloalkyl
haloalkyl
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チョウドリー、サムナス
リー、クオン
ハン、シンピン
アルバース、アーロン
グオ、ズオジュン
－ ファ クァク、スン
ファム、フォンリー
ランク、スティーブン
シー、ソンユエン
スペバック、ウェイン
チャン、ドンユ
チャン、ジァジョン
チャン、イン
ヴァル、マーク ヴァンダー
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オプナ バイオ ソシエテ アノニム
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    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
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JP2024543955A 2022-01-28 2023-01-27 Ｙａｐ／ｔｅａｄ調節およびそれらの適応症のための化合物および方法 Withdrawn JP2025503945A (ja)

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US202263304504P 2022-01-28 2022-01-28
US63/304,504 2022-01-28
US202263309442P 2022-02-11 2022-02-11
US63/309,442 2022-02-11
PCT/US2023/011752 WO2023147063A2 (en) 2022-01-28 2023-01-27 Compounds and methods for yap/tead modulation and indications therefor

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JP2025503945A true JP2025503945A (ja) 2025-02-06
JP2025503945A5 JP2025503945A5 (https=) 2026-01-27

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CN119968359A (zh) 2022-09-29 2025-05-09 英矽智能科技知识产权有限公司 Tead抑制剂及其使用方法
AU2024212529A1 (en) * 2023-01-27 2025-06-19 Opna Bio SA Compounds and methods for yap/tead modulation and indications therefor
WO2025209524A1 (en) * 2024-04-03 2025-10-09 Insilico Medicine Ip Limited Crystalline tead inhibitor and uses thereof

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WO2007048788A1 (en) * 2005-10-26 2007-05-03 Laboratoires Serono S.A. Sulfonamide derivatives and use thereof for the modulation of metalloproteinases
KR20140033377A (ko) * 2011-05-10 2014-03-18 길리애드 사이언시즈, 인코포레이티드 나트륨 채널 조절제로서의 융합된 헤테로시클릭 화합물
AU2015217185B2 (en) * 2014-02-12 2018-04-05 Purdue Pharma L.P. Isoquinoline derivatives and use thereof
WO2017009650A1 (en) * 2015-07-14 2017-01-19 Mission Therapeutics Limited Cyanopyrrolidines as dub inhibitors for the treatment of cancer
JP2019501143A (ja) * 2015-12-04 2019-01-17 ヴィーブ ヘルスケア ユーケー リミテッド テトラヒドロイソキノリン誘導体
MX2021012638A (es) * 2019-04-16 2022-01-04 Vivace Therapeutics Inc Compuestos biciclicos.
CN113801060B (zh) * 2020-06-13 2025-06-27 苏州鹏旭医药科技有限公司 一种多取代异喹啉化合物的制备方法
WO2022240966A1 (en) * 2021-05-11 2022-11-17 Opna Immuno-Oncology Sa Compounds and methods for yap/tead modulation and indications therefor

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