JP2025023868A - Ｎｏｄ様受容体タンパク質３の阻害剤として有用なフタラジン誘導体 - Google Patents

Ｎｏｄ様受容体タンパク質３の阻害剤として有用なフタラジン誘導体 Download PDF

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Publication number
JP2025023868A
JP2025023868A JP2024174701A JP2024174701A JP2025023868A JP 2025023868 A JP2025023868 A JP 2025023868A JP 2024174701 A JP2024174701 A JP 2024174701A JP 2024174701 A JP2024174701 A JP 2024174701A JP 2025023868 A JP2025023868 A JP 2025023868A
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Japan
Prior art keywords
alkyl
trifluoromethyl
pyridazin
pyrido
unsubstituted
Prior art date
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Pending
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JP2024174701A
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English (en)
Japanese (ja)
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JP2025023868A5 (https=
Inventor
ヘイズ，ドナ・エー・エー・ダブリュー
A A W Hayes Donna
カルナチ，プラバー
Karnachi Prabha
キーファー，マデリン・アイリーン
Eileen KIEFFER Madeleine
マックリーモント，カイル・エス
S Mcclymont Kyle
マーチャント，ローハン・ラジーブ
Rajiv Merchant Rohan
メトワリー，エッサム
METWALLY Essam
ナイア，アニルクマール・ジー
G Nair Anilkumar
チー，ニン
Ning Qi
サンゾーネ，ジリアン・ローズ
Rose SANZONE Jillian
シャメッタ，ヌンツィオ
Sciammetta Nunzio
サウスゲート，エマ・エイチ
H Southgate Emma
タン，ジェン
Jian Tan
タオカ，ブランドン・エム
M Taoka Brandon
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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Priority claimed from JP2024543314A external-priority patent/JP7707451B2/ja
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of JP2025023868A publication Critical patent/JP2025023868A/ja
Publication of JP2025023868A5 publication Critical patent/JP2025023868A5/ja
Pending legal-status Critical Current

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JP2024174701A 2022-09-23 2024-10-04 Ｎｏｄ様受容体タンパク質３の阻害剤として有用なフタラジン誘導体 Pending JP2025023868A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263409432P 2022-09-23 2022-09-23
US63/409,432 2022-09-23
JP2024543314A JP7707451B2 (ja) 2022-09-23 2023-09-21 Ｎｏｄ様受容体タンパク質３の阻害剤として有用なフタラジン誘導体

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JP2024543314A Division JP7707451B2 (ja) 2022-09-23 2023-09-21 Ｎｏｄ様受容体タンパク質３の阻害剤として有用なフタラジン誘導体

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JP2025023868A true JP2025023868A (ja) 2025-02-17
JP2025023868A5 JP2025023868A5 (https=) 2025-05-19

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025512651A (ja) * 2022-09-23 2025-04-22 メルク・シャープ・アンド・ドーム・エルエルシー Ｎｏｄ様受容体タンパク質３の阻害剤として有用なフタラジン誘導体

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016520115A (ja) * 2013-05-28 2016-07-11 レデックス ファーマ ピーエルシーＲｅｄｘ Ｐｈａｒｍａ Ｐｌｃ ヘッジホッグシグナル伝達経路阻害剤としての複素環化合物
WO2022135567A1 (zh) * 2020-12-25 2022-06-30 上海拓界生物医药科技有限公司 一类含哒嗪的化合物及其医药用途
WO2022166890A1 (zh) * 2021-02-08 2022-08-11 南京明德新药研发有限公司 取代的哒嗪苯酚类衍生物
WO2022216971A1 (en) * 2021-04-07 2022-10-13 Ventus Therapeutics U.S., Inc. Pyridazine compounds for inhibiting nlrp3
WO2023028534A1 (en) * 2021-08-25 2023-03-02 Ptc Therapeutics, Inc. Inhibitors of nlrp3

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016520115A (ja) * 2013-05-28 2016-07-11 レデックス ファーマ ピーエルシーＲｅｄｘ Ｐｈａｒｍａ Ｐｌｃ ヘッジホッグシグナル伝達経路阻害剤としての複素環化合物
WO2022135567A1 (zh) * 2020-12-25 2022-06-30 上海拓界生物医药科技有限公司 一类含哒嗪的化合物及其医药用途
WO2022166890A1 (zh) * 2021-02-08 2022-08-11 南京明德新药研发有限公司 取代的哒嗪苯酚类衍生物
WO2022216971A1 (en) * 2021-04-07 2022-10-13 Ventus Therapeutics U.S., Inc. Pyridazine compounds for inhibiting nlrp3
WO2023028534A1 (en) * 2021-08-25 2023-03-02 Ptc Therapeutics, Inc. Inhibitors of nlrp3

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NORBERT HAIDER ET AL.: "Pyridazin-Analoga biologisch aktiver Verbindungen, 2 Mitt. 4-Aryl-pyridazino[4,5-d]pyridazine mit cy", ARCH. PHARM. (WEINHEIM), vol. 315, JPN6025044105, 1982, pages 778 - 783, ISSN: 0005718430 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025512651A (ja) * 2022-09-23 2025-04-22 メルク・シャープ・アンド・ドーム・エルエルシー Ｎｏｄ様受容体タンパク質３の阻害剤として有用なフタラジン誘導体
JP7707451B2 (ja) 2022-09-23 2025-07-14 メルク・シャープ・アンド・ドーム・エルエルシー Ｎｏｄ様受容体タンパク質３の阻害剤として有用なフタラジン誘導体

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