JP2024545873A - インテグリンサブユニットα１（ＩＴＧＡ１）阻害剤による肺の状態の治療 - Google Patents

インテグリンサブユニットα１（ＩＴＧＡ１）阻害剤による肺の状態の治療 Download PDF

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Publication number
JP2024545873A
JP2024545873A JP2024533988A JP2024533988A JP2024545873A JP 2024545873 A JP2024545873 A JP 2024545873A JP 2024533988 A JP2024533988 A JP 2024533988A JP 2024533988 A JP2024533988 A JP 2024533988A JP 2024545873 A JP2024545873 A JP 2024545873A
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JP
Japan
Prior art keywords
itga1
variant
nucleic acid
acid molecule
nucleotide
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Pending
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JP2024533988A
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English (en)
Japanese (ja)
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JP2024545873A5 (https=
Inventor
アレン レベズ フェレイラ、マヌエル
イー． ホロウィッツ、ジュリー
シミノビッチ、キャサリン
アベカシス、ゴンサロ
バラス、アリス
クリスティーナ スチウ、マリア
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of JP2024545873A publication Critical patent/JP2024545873A/ja
Publication of JP2024545873A5 publication Critical patent/JP2024545873A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2024533988A 2021-12-17 2022-12-16 インテグリンサブユニットα１（ＩＴＧＡ１）阻害剤による肺の状態の治療 Pending JP2024545873A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163291194P 2021-12-17 2021-12-17
US63/291,194 2021-12-17
PCT/US2022/081750 WO2023114969A2 (en) 2021-12-17 2022-12-16 Treatment of lung conditions with integrin subunit alpha 1 (itga1) inhibitors

Publications (2)

Publication Number Publication Date
JP2024545873A true JP2024545873A (ja) 2024-12-13
JP2024545873A5 JP2024545873A5 (https=) 2025-12-09

Family

ID=85158395

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024533988A Pending JP2024545873A (ja) 2021-12-17 2022-12-16 インテグリンサブユニットα１（ＩＴＧＡ１）阻害剤による肺の状態の治療

Country Status (7)

Country Link
US (1) US20230192864A1 (https=)
EP (1) EP4448766A2 (https=)
JP (1) JP2024545873A (https=)
CN (1) CN118804976A (https=)
CA (1) CA3240997A1 (https=)
MX (1) MX2024007460A (https=)
WO (1) WO2023114969A2 (https=)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA73300C2 (en) * 1999-06-01 2005-07-15 Biogen Inc Use of composition containing homolog of antibody antagonizing interaction between integrin with alpha-4 subunit and its ligand for treating fibrosis
WO2006124269A2 (en) * 2005-05-16 2006-11-23 Amgen Fremont Inc. Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders
JP2017510552A (ja) * 2014-02-07 2017-04-13 イーフェクター セラピューティクス， インコーポレイテッド 線維性疾患を治療するための方法
EP3458157A4 (en) * 2016-05-19 2020-05-27 Momenta Pharmaceuticals, Inc. METHOD FOR TREATING DISEASES RELATING TO FIBROSE AND SYSTEMIC Sclerosis
WO2018159432A1 (ja) * 2017-03-03 2018-09-07 ロート製薬株式会社 間葉系幹細胞及び医薬組成物
CN111643649A (zh) * 2020-05-20 2020-09-11 博奥生物集团有限公司 防治免疫相关疾病的中药材及其组合物

Also Published As

Publication number Publication date
CN118804976A (zh) 2024-10-18
CA3240997A1 (en) 2023-06-22
WO2023114969A2 (en) 2023-06-22
US20230192864A1 (en) 2023-06-22
EP4448766A2 (en) 2024-10-23
MX2024007460A (es) 2024-07-09
WO2023114969A3 (en) 2023-07-27

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