JP2024545144A - Ｏｍｎｉ－１０３ ｃｒｉｓｐｒヌクレアーゼ－ｒｎａ複合体 - Google Patents

Ｏｍｎｉ－１０３ ｃｒｉｓｐｒヌクレアーゼ－ｒｎａ複合体 Download PDF

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JP2024545144A
JP2024545144A JP2024534340A JP2024534340A JP2024545144A JP 2024545144 A JP2024545144 A JP 2024545144A JP 2024534340 A JP2024534340 A JP 2024534340A JP 2024534340 A JP2024534340 A JP 2024534340A JP 2024545144 A JP2024545144 A JP 2024545144A
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sequence
tracrrna
composition according
seq
nucleotides
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JP2024545144A5 (enExample
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イザール、リオル
ロッカー、リアット
マールバッハ・バール、ナダブ
ヘヒト、ニル
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エメンドバイオ・インコーポレイテッド
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2024534340A 2021-12-07 2022-12-06 Ｏｍｎｉ－１０３ ｃｒｉｓｐｒヌクレアーゼ－ｒｎａ複合体 Pending JP2024545144A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163286855P 2021-12-07 2021-12-07
US63/286,855 2021-12-07
PCT/US2022/081019 WO2023107946A2 (en) 2021-12-07 2022-12-06 Omni-103 crispr nuclease-rna complexes

Publications (2)

Publication Number Publication Date
JP2024545144A true JP2024545144A (ja) 2024-12-05
JP2024545144A5 JP2024545144A5 (enExample) 2025-12-15

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JP2024534340A Pending JP2024545144A (ja) 2021-12-07 2022-12-06 Ｏｍｎｉ－１０３ ｃｒｉｓｐｒヌクレアーゼ－ｒｎａ複合体

Country Status (9)

Country Link
US (1) US20250034596A1 (enExample)
EP (1) EP4444876A2 (enExample)
JP (1) JP2024545144A (enExample)
KR (1) KR20240135610A (enExample)
CN (2) CN116887854A (enExample)
AU (1) AU2022405520A1 (enExample)
CA (1) CA3240329A1 (enExample)
IL (1) IL313397A (enExample)
WO (1) WO2023107946A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024506608A (ja) 2021-02-08 2024-02-14 エメンドバイオ・インコーポレイテッド Ｏｍｎｉ－１０３ ｃｒｉｓｐｒヌクレアーゼ
US12091688B2 (en) 2021-02-08 2024-09-17 Emendobio Inc. OMNI-103 CRISPR nuclease
CN120837655A (zh) * 2025-09-24 2025-10-28 中国人民解放军军事科学院军事医学研究院 磷酸化抑制工具在制备预防和/或治疗三阴性乳腺癌的药物中的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020069029A1 (en) * 2018-09-26 2020-04-02 Emendobio Inc. Novel crispr nucleases
IL298577A (en) * 2020-05-27 2023-01-01 Emendobio Inc Biallelic silencing of sarm1

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Publication number Publication date
KR20240135610A (ko) 2024-09-11
WO2023107946A3 (en) 2023-08-03
IL313397A (en) 2024-08-01
CN118660967A (zh) 2024-09-17
EP4444876A2 (en) 2024-10-16
US20250034596A1 (en) 2025-01-30
CN116887854A (zh) 2023-10-13
WO2023107946A2 (en) 2023-06-15
AU2022405520A1 (en) 2024-07-04
CA3240329A1 (en) 2023-06-15

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