JP2024542692A - 環化２－アミノ－３－シアノチオフェンを含むｋｒａ分解化合物 - Google Patents

環化２－アミノ－３－シアノチオフェンを含むｋｒａ分解化合物 Download PDF

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Publication number
JP2024542692A
JP2024542692A JP2024532456A JP2024532456A JP2024542692A JP 2024542692 A JP2024542692 A JP 2024542692A JP 2024532456 A JP2024532456 A JP 2024532456A JP 2024532456 A JP2024532456 A JP 2024532456A JP 2024542692 A JP2024542692 A JP 2024542692A
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JP
Japan
Prior art keywords
compound
formula
alkyl
kras
cancer
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Pending
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JP2024532456A
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English (en)
Japanese (ja)
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JP2024542692A5 (https=
Inventor
ブロカー，ヨアヒム
アボット，ジェイソン
シウリ，アレッシオ
ツイ，ジェンウェン
ディールス，エメリネ
ファーナビー，ウィリアム
フェシク，スティーヴン・ダブリュー
ゴウルナー，アンドレアス
グッドウィン－ティンダール，ジェイク
ホッジズ，ティム
コフィンク，クリスティアーネ
リトル，アンドリュー
マントゥリディス，アンドレアス
マクレナン，ロス
ポポウ，ヨハネス
サルカール，ドルバ
シュミーデル，マルティン
スメスルスト，クリスティアン・アラン・パウル
トレイナー，ニコール
ウォーターソン，アレックス
ヴァインスタブル，ハーラルト
ジョン，シーイン
ゾルマン，デーヴィッド
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Vanderbilt University
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Vanderbilt University
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Publication of JP2024542692A publication Critical patent/JP2024542692A/ja
Publication of JP2024542692A5 publication Critical patent/JP2024542692A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2024532456A 2021-12-01 2022-11-30 環化２－アミノ－３－シアノチオフェンを含むｋｒａ分解化合物 Pending JP2024542692A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163284751P 2021-12-01 2021-12-01
US63/284,751 2021-12-01
PCT/EP2022/083950 WO2023099620A1 (en) 2021-12-01 2022-11-30 Kras degrading compounds comprising annulated 2-amino-3-cyano thiophenes

Publications (2)

Publication Number Publication Date
JP2024542692A true JP2024542692A (ja) 2024-11-15
JP2024542692A5 JP2024542692A5 (https=) 2025-11-26

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ID=84537055

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JP2024532456A Pending JP2024542692A (ja) 2021-12-01 2022-11-30 環化２－アミノ－３－シアノチオフェンを含むｋｒａ分解化合物

Country Status (5)

Country Link
US (1) US20250145608A1 (https=)
EP (1) EP4441051A1 (https=)
JP (1) JP2024542692A (https=)
CN (1) CN118591540A (https=)
WO (1) WO2023099620A1 (https=)

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US12448399B2 (en) 2023-01-26 2025-10-21 Arvinas Operations, Inc. Cereblon-based KRAS degrading PROTACs and uses related thereto
KR20260041941A (ko) 2023-03-15 2026-03-27 콴타 테라퓨틱스, 인크. Kras 조절 인자 및 이의 용도
AU2024241633A1 (en) 2023-03-30 2025-11-06 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
WO2025016899A1 (en) 2023-07-19 2025-01-23 Bayer Aktiengesellschaft Spirocyclic compounds for the treatment of cancer
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US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
CN121941690A (zh) 2023-10-03 2026-04-28 Paq医疗公司 Kras蛋白水解靶向嵌合体
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
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CN118591540A (zh) 2024-09-03
EP4441051A1 (en) 2024-10-09
WO2023099620A1 (en) 2023-06-08
US20250145608A1 (en) 2025-05-08

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