JP2024539641A - 癌の治療に使用するための変異ｒｅｔキナーゼの阻害剤 - Google Patents

癌の治療に使用するための変異ｒｅｔキナーゼの阻害剤 Download PDF

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JP2024539641A
JP2024539641A JP2024522321A JP2024522321A JP2024539641A JP 2024539641 A JP2024539641 A JP 2024539641A JP 2024522321 A JP2024522321 A JP 2024522321A JP 2024522321 A JP2024522321 A JP 2024522321A JP 2024539641 A JP2024539641 A JP 2024539641A
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ret
cancer
alkyl
compound
formula
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Japanese (ja)
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JP2024539641A5 (https=
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ポラドス エンリケ
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ステムライン セラピューティクス，インコーポレーテッド
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Publication of JP2024539641A publication Critical patent/JP2024539641A/ja
Publication of JP2024539641A5 publication Critical patent/JP2024539641A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2024522321A 2021-10-15 2022-10-13 癌の治療に使用するための変異ｒｅｔキナーゼの阻害剤 Pending JP2024539641A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163256037P 2021-10-15 2021-10-15
US63/256,037 2021-10-15
US202263358897P 2022-07-07 2022-07-07
US63/358,897 2022-07-07
PCT/US2022/078023 WO2023064843A1 (en) 2021-10-15 2022-10-13 Inhibitors of mutant ret kinases for use in treating cancer

Publications (2)

Publication Number Publication Date
JP2024539641A true JP2024539641A (ja) 2024-10-29
JP2024539641A5 JP2024539641A5 (https=) 2025-10-22

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ID=84238097

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Application Number Title Priority Date Filing Date
JP2024522321A Pending JP2024539641A (ja) 2021-10-15 2022-10-13 癌の治療に使用するための変異ｒｅｔキナーゼの阻害剤

Country Status (4)

Country Link
US (1) US20250064809A1 (https=)
EP (1) EP4415718A1 (https=)
JP (1) JP2024539641A (https=)
WO (1) WO2023064843A1 (https=)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0915231A2 (pt) * 2008-07-08 2018-06-12 Intellikine Inc compostos inibidores de quinase e métodos de uso
WO2017178844A1 (en) 2016-04-15 2017-10-19 Cancer Research Technology Limited Heterocyclic compounds as ret kinase inhibitors
GB201705971D0 (en) * 2017-04-13 2017-05-31 Cancer Res Tech Ltd Inhibitor compounds
EP3740490A1 (en) * 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors
JP7060694B2 (ja) * 2018-01-18 2022-04-26 アレイ バイオファーマ インコーポレイテッド Ｒｅｔキナーゼ阻害剤としての置換ピロロ［２，３－ｄ］ピリミジン化合物

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EP4415718A1 (en) 2024-08-21
WO2023064843A1 (en) 2023-04-20
US20250064809A1 (en) 2025-02-27

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