JP2024534541A5 - - Google Patents
Info
- Publication number
- JP2024534541A5 JP2024534541A5 JP2024518109A JP2024518109A JP2024534541A5 JP 2024534541 A5 JP2024534541 A5 JP 2024534541A5 JP 2024518109 A JP2024518109 A JP 2024518109A JP 2024518109 A JP2024518109 A JP 2024518109A JP 2024534541 A5 JP2024534541 A5 JP 2024534541A5
- Authority
- JP
- Japan
- Prior art keywords
- unit dose
- muscle
- modified bont
- bont
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2113602.3 | 2021-09-23 | ||
| GBGB2113602.3A GB202113602D0 (en) | 2021-09-23 | 2021-09-23 | Treatment of a disorder affecting an eyelid muscle of a subject |
| GB2206360.6 | 2022-04-29 | ||
| GBGB2206360.6A GB202206360D0 (en) | 2022-04-29 | 2022-04-29 | Treatment of a disorder affecting an eyelid muscle of a subject |
| PCT/GB2022/052415 WO2023047127A1 (en) | 2021-09-23 | 2022-09-23 | Modified bont/a for use in the treatment of a disorder affecting an eyelid muscle of a subject |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024534541A JP2024534541A (ja) | 2024-09-20 |
| JP2024534541A5 true JP2024534541A5 (enExample) | 2025-09-04 |
Family
ID=83507580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024518109A Pending JP2024534541A (ja) | 2021-09-23 | 2022-09-23 | 被験体の眼瞼筋を冒す障害の治療における使用のための改変ＢｏＮＴ／Ａ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20250179461A1 (enExample) |
| EP (1) | EP4404955A1 (enExample) |
| JP (1) | JP2024534541A (enExample) |
| KR (1) | KR20240067100A (enExample) |
| AU (1) | AU2022351260A1 (enExample) |
| CA (1) | CA3228712A1 (enExample) |
| WO (1) | WO2023047127A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB202206361D0 (en) * | 2022-04-29 | 2022-06-15 | Ipsen Biopharm Ltd | Treatment of a facial dystonia |
| GB202214232D0 (en) | 2022-09-28 | 2022-11-09 | Ispen Biopharm Ltd | Clostridial neurotoxins comprising an activating exogenous protease cleavage site |
| GB202214229D0 (en) | 2022-09-28 | 2022-11-09 | Ipsen Biopharm Ltd | Clostridial neurotoxins comprising an activating endosomal protease cleavage site |
| WO2025093844A1 (en) * | 2023-11-01 | 2025-05-08 | Ipsen Biopharm Limited | Use of chimeric botulinum toxin a for treating blepharospasm and hemifacial spasm |
| GB202318884D0 (en) | 2023-12-11 | 2024-01-24 | Ipsen Biopharm Ltd | Formulation |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| DE102004043009A1 (de) | 2004-09-06 | 2006-03-23 | Toxogen Gmbh | Transportprotein zum Einbringen chemischer Verbindungen in Nervenzellen |
| DE102005019302A1 (de) | 2005-04-26 | 2006-11-16 | Toxogen Gmbh | Carrier zum Targeting von Nervenzellen |
| ATE518882T1 (de) | 2005-09-19 | 2011-08-15 | Allergan Inc | Mit clostridientoxin aktivierbare clostridientoxine |
| AU2010236613B2 (en) | 2009-04-14 | 2016-07-07 | Mcw Research Foundation, Inc. | Engineered botulinum neurotoxin |
| US8853360B2 (en) | 2010-06-23 | 2014-10-07 | Wisconsin Alumni Research Foundation | Engineered botulinum neurotoxin C1 with selective substrate specificity |
| ES2708661T3 (es) | 2011-05-19 | 2019-04-10 | Ipsen Bioinnovation Ltd | Métodos para la fabricación de polipéptidos proteolíticamente procesados |
| UA116985C2 (uk) | 2012-05-30 | 2018-06-11 | Президент Енд Феллоуз Оф Гарвард Колледж | Рекомбінантний ботулінічний нейротоксин |
| WO2014079495A1 (en) | 2012-11-21 | 2014-05-30 | Syntaxin Limited | Methods for the manufacture of proteolytically processed polypeptides |
| GB201312317D0 (en) | 2013-07-09 | 2013-08-21 | Syntaxin Ltd | Cationic neurotoxins |
| GB201407525D0 (en) | 2014-04-29 | 2014-06-11 | Syntaxin Ltd | Manufacture of recombinant clostridium botulinum neurotoxins |
| PT3274364T (pt) | 2015-03-26 | 2021-11-05 | Harvard College | Neurotoxina botulínica manipulada |
| GB201517450D0 (en) | 2015-10-02 | 2015-11-18 | Ipsen Biopharm Ltd | Method |
| GB201607901D0 (en) | 2016-05-05 | 2016-06-22 | Ipsen Biopharm Ltd | Chimeric neurotoxins |
-
2022
- 2022-09-23 EP EP22782758.1A patent/EP4404955A1/en active Pending
- 2022-09-23 US US18/690,479 patent/US20250179461A1/en active Pending
- 2022-09-23 CA CA3228712A patent/CA3228712A1/en active Pending
- 2022-09-23 KR KR1020247012920A patent/KR20240067100A/ko active Pending
- 2022-09-23 AU AU2022351260A patent/AU2022351260A1/en active Pending
- 2022-09-23 JP JP2024518109A patent/JP2024534541A/ja active Pending
- 2022-09-23 WO PCT/GB2022/052415 patent/WO2023047127A1/en not_active Ceased
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