JP2024532792A - 流体サンプルの複数の区分けされた部分を評価するための閉鎖型マイクロ流体カートリッジ - Google Patents

流体サンプルの複数の区分けされた部分を評価するための閉鎖型マイクロ流体カートリッジ Download PDF

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Publication number
JP2024532792A
JP2024532792A JP2024508609A JP2024508609A JP2024532792A JP 2024532792 A JP2024532792 A JP 2024532792A JP 2024508609 A JP2024508609 A JP 2024508609A JP 2024508609 A JP2024508609 A JP 2024508609A JP 2024532792 A JP2024532792 A JP 2024532792A
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Japan
Prior art keywords
cartridge
fluid sample
channels
fluid
channel
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Pending
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JP2024508609A
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Japanese (ja)
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JP2024532792A5 (cg-RX-API-DMAC7.html
Inventor
エイチ フリードマン，ガリット
シルバーマン，レオニード
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Coagulo Medical Technologies Inc
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Coagulo Medical Technologies Inc
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Publication of JP2024532792A publication Critical patent/JP2024532792A/ja
Publication of JP2024532792A5 publication Critical patent/JP2024532792A5/ja
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
JP2024508609A 2021-08-12 2022-08-09 流体サンプルの複数の区分けされた部分を評価するための閉鎖型マイクロ流体カートリッジ Pending JP2024532792A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163232453P 2021-08-12 2021-08-12
US63/232,453 2021-08-12
PCT/US2022/039851 WO2023018728A1 (en) 2021-08-12 2022-08-09 Closed microfluidic cartridge for evaluating multiple, isolated portions of a fluid sample

Publications (2)

Publication Number Publication Date
JP2024532792A true JP2024532792A (ja) 2024-09-10
JP2024532792A5 JP2024532792A5 (cg-RX-API-DMAC7.html) 2025-08-20

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JP2024508609A Pending JP2024532792A (ja) 2021-08-12 2022-08-09 流体サンプルの複数の区分けされた部分を評価するための閉鎖型マイクロ流体カートリッジ

Country Status (8)

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US (1) US20250135454A1 (cg-RX-API-DMAC7.html)
EP (1) EP4384320A4 (cg-RX-API-DMAC7.html)
JP (1) JP2024532792A (cg-RX-API-DMAC7.html)
AU (1) AU2022328186A1 (cg-RX-API-DMAC7.html)
CA (1) CA3228667A1 (cg-RX-API-DMAC7.html)
IL (1) IL310750A (cg-RX-API-DMAC7.html)
TW (1) TW202327729A (cg-RX-API-DMAC7.html)
WO (1) WO2023018728A1 (cg-RX-API-DMAC7.html)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025106277A1 (en) * 2023-11-13 2025-05-22 Meliolabs Inc. Devices and methods for partitioning samples for digital assays

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002503331A (ja) * 1995-12-05 2002-01-29 ガメラ バイオサイエンス コーポレイション 機内に搭載された情報科学を備えた超微量液体素子工学システムにおいて液体移動を推進するために求心性加速を使用するための装置及び方法
US20090053108A1 (en) * 2007-08-22 2009-02-26 Samsung Electronics Co., Ltd. Centrifugal force-based microfluidic device for blood chemistry analysis
WO2012031630A1 (en) * 2010-09-09 2012-03-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Microfluidic device, microfluidic dosing system and method for microfluidic flow measurement and dosing
WO2013167716A2 (en) * 2012-05-09 2013-11-14 Stat-Diagnostica & Innovation, S.L. Plurality of reaction chambers in a test cartridge
WO2020060475A1 (en) * 2018-09-20 2020-03-26 Astrego Diagnostics Ab Sample loading cartridge

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8303911B2 (en) * 2009-10-19 2012-11-06 The Regents Of The University Of California Centrifugal microfluidic system for nucleic acid sample preparation, amplification, and detection
EP3425401B1 (en) * 2012-10-08 2023-09-27 BL Technologies, Inc. Preloaded test substrates for testing lal-reactive substances, methods of use, and methods of making
US9700888B1 (en) * 2016-04-13 2017-07-11 Ipmd Inc. Point of care medical device for detecting infectious diseases
EP3658920A1 (en) 2017-07-28 2020-06-03 Massachusetts Institute Of Technology Methods and devices for detection of anticoagulants in plasma and whole blood
PL425106A1 (pl) * 2018-03-30 2019-10-07 Bacteromic Spółka Z Ograniczoną Odpowiedzialnością Chip mikroprzepływowy
EP4010481A4 (en) * 2019-08-09 2023-09-20 Nutcracker Therapeutics, Inc. MICROFLUIDIC DEVICE AND METHODS OF USE

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002503331A (ja) * 1995-12-05 2002-01-29 ガメラ バイオサイエンス コーポレイション 機内に搭載された情報科学を備えた超微量液体素子工学システムにおいて液体移動を推進するために求心性加速を使用するための装置及び方法
US20090053108A1 (en) * 2007-08-22 2009-02-26 Samsung Electronics Co., Ltd. Centrifugal force-based microfluidic device for blood chemistry analysis
WO2012031630A1 (en) * 2010-09-09 2012-03-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Microfluidic device, microfluidic dosing system and method for microfluidic flow measurement and dosing
JP2013543447A (ja) * 2010-09-09 2013-12-05 フラウンホッファー−ゲゼルシャフト ツァ フェルダールング デァ アンゲヴァンテン フォアシュンク エー．ファオ 微小流体デバイス、微小流体注入システム、および微小流体のフロー測定と注入の方法
WO2013167716A2 (en) * 2012-05-09 2013-11-14 Stat-Diagnostica & Innovation, S.L. Plurality of reaction chambers in a test cartridge
JP2015516085A (ja) * 2012-05-09 2015-06-04 スタット−ダイアグノスティカ アンド イノベーション， エス． エル． 試験カートリッジにおける複数の反応チャンバ
WO2020060475A1 (en) * 2018-09-20 2020-03-26 Astrego Diagnostics Ab Sample loading cartridge

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Publication number Publication date
US20250135454A1 (en) 2025-05-01
IL310750A (en) 2024-04-01
AU2022328186A1 (en) 2024-02-29
TW202327729A (zh) 2023-07-16
EP4384320A1 (en) 2024-06-19
WO2023018728A1 (en) 2023-02-16
CA3228667A1 (en) 2023-02-16
EP4384320A4 (en) 2025-06-25

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