JP2024532596A5 - - Google Patents

Info

Publication number
JP2024532596A5
JP2024532596A5 JP2024536342A JP2024536342A JP2024532596A5 JP 2024532596 A5 JP2024532596 A5 JP 2024532596A5 JP 2024536342 A JP2024536342 A JP 2024536342A JP 2024536342 A JP2024536342 A JP 2024536342A JP 2024532596 A5 JP2024532596 A5 JP 2024532596A5
Authority
JP
Japan
Prior art keywords
nucleic acid
acid molecule
recombinant protein
vector
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2024536342A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024532596A (ja
JP7687643B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CN2022/114516 external-priority patent/WO2023025193A1/zh
Publication of JP2024532596A publication Critical patent/JP2024532596A/ja
Publication of JP2024532596A5 publication Critical patent/JP2024532596A5/ja
Application granted granted Critical
Publication of JP7687643B2 publication Critical patent/JP7687643B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2024536342A 2021-08-25 2022-08-24 神経成長因子突然変異体の組換えタンパク質及びその使用 Active JP7687643B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202110981721 2021-08-25
CN202110981721.5 2021-08-25
PCT/CN2022/114516 WO2023025193A1 (zh) 2021-08-25 2022-08-24 神经生长因子突变体重组蛋白及其应用

Publications (3)

Publication Number Publication Date
JP2024532596A JP2024532596A (ja) 2024-09-05
JP2024532596A5 true JP2024532596A5 (https=) 2024-09-19
JP7687643B2 JP7687643B2 (ja) 2025-06-03

Family

ID=82862610

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024536342A Active JP7687643B2 (ja) 2021-08-25 2022-08-24 神経成長因子突然変異体の組換えタンパク質及びその使用

Country Status (5)

Country Link
US (1) US20250009846A1 (https=)
EP (1) EP4375367B1 (https=)
JP (1) JP7687643B2 (https=)
CN (1) CN114933657B (https=)
WO (1) WO2023025193A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114933657B (zh) * 2021-08-25 2024-02-02 上海交通大学医学院 神经生长因子突变体重组蛋白及其应用
WO2024189146A1 (en) * 2023-03-15 2024-09-19 Versameb Ag Rna encoding a protein
WO2025130564A1 (zh) * 2023-12-20 2025-06-26 广州市恒诺康医药科技有限公司 编码神经生长因子(NGF)的mRNA及其组合物和应用
WO2025184345A1 (en) * 2024-02-27 2025-09-04 Ohio State Innovation Foundation Methods and compositions for treating neuropathy
EP4623927A1 (en) * 2024-03-27 2025-10-01 Dompe' Farmaceutici SpA Ngf for use in the prevention or treatment of motor impairment caused by neonatal hypoxic-ischemic encephalopathy

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080286323A1 (en) * 2004-01-19 2008-11-20 Nsgene A/S Human Therapeutic Cells Secreting Nerve Growth Factor
EP2048237A1 (en) 2007-10-05 2009-04-15 Avir Green Hills Biotechnology Research Development Trade Ag Replication deficient Influenza virus for the expression of heterologous sequences
JP5634272B2 (ja) * 2008-03-14 2014-12-03 ヒューマンザイム リミテッド ヒト細胞発現系を用いる真正ヒトタンパク質の組換え生産
CN102083451A (zh) * 2008-06-12 2011-06-01 赛恩泰新公司 癌症的抑制
EP2367564A1 (en) * 2008-12-22 2011-09-28 Universität Regensburg Norrin in the treatment of diseases associated with an increased tgf-beta activity
AU2010206374B2 (en) * 2009-01-23 2013-01-17 Gloriana Therapeutics Sarl Improved cell lines and their use in encapsulated cell biodelivery
AU2012205583B2 (en) 2011-01-11 2016-01-21 Fate Therapeutics, Inc. Novel Wnt compositions and therapeutic uses of such compositions
WO2012170452A2 (en) * 2011-06-06 2012-12-13 The Regents Of The University Of California Compositions and methods for treating neurodegenerative diseases
CN106008722B (zh) * 2016-05-13 2019-10-15 未名生物医药有限公司 一种重组β-hNGF-Fc融合蛋白、制备方法及用途
CN108178798B (zh) * 2016-12-08 2021-03-30 苏州方德门达新药开发有限公司 pH工程化的NGF抗体及其医药用途
CA3053267A1 (en) * 2017-02-10 2018-08-16 Vivibaba, Inc Compositions and methods for recombinant nerve growth factor
GB201705484D0 (en) * 2017-04-05 2017-05-17 Quethera Ltd Genetic construct
CN108314723A (zh) * 2018-01-11 2018-07-24 温州医科大学 一种人源突变型神经生长因子及其制备方法和应用
CN108610398B (zh) * 2018-01-15 2020-08-11 武汉海特生物制药股份有限公司 一段功能序列及在分泌蛋白表达中的应用
PE20230486A1 (es) 2020-02-14 2023-03-21 Univ Washington Polipeptidos y sus usos
CN112794893A (zh) 2021-01-29 2021-05-14 华中农业大学 一种捻转血矛线虫Hc-H11-2重组蛋白的构建方法及其应用
CN114933657B (zh) * 2021-08-25 2024-02-02 上海交通大学医学院 神经生长因子突变体重组蛋白及其应用

Similar Documents

Publication Publication Date Title
JP2024532596A5 (https=)
AU2014329452B2 (en) Polynucleotides encoding low density lipoprotein receptor
CN1286981C (zh) 表达人类cyp2j2反义基因的重组腺相关病毒及其制备方法
CN117904112A (zh) 调节性多核苷酸
AU2014337156A1 (en) Compositions and methods for tolerizing cellular systems
US20250001011A1 (en) Engineered adar-recruiting rnas and methods of use thereof
WO2023104028A1 (zh) 非编码rna介导的神经性疾病治疗
US20250257368A1 (en) In vitro assembly of anellovirus capsids enclosing rna
CN108251420A (zh) 抑制人和动物中CTGF基因表达的siRNA、包含其的组合物及其应用
TW202223095A (zh) 串聯指環病毒構築體
CN114599789A (zh) 人工合成mRNA及其利用
TW202417632A (zh) 新穎指環病毒科(anelloviridae)載體組合物及方法
EP4125933A1 (en) Compositions and methods for treating cystic fibrosis
CN108251421A (zh) 抑制人和动物中COL1A1基因表达的siRNA、包含其的组合物及其应用
CN118291454A (zh) Rna分子在调控毛囊干细胞干性中的应用
CN108866058A (zh) 靶向KRAS的siRNA及其在制备胰腺癌治疗药物中的应用
CN115896104A (zh) 一种去靶向神经元递送的工程化mRNA及其制备方法和应用
CN114807127A (zh) 用于结缔组织生长因子的小干扰rna及其应用
RU2852567C2 (ru) Сконструированный полипептид человеческого фактора VIII (hFVIII) с повышенной коагулирующей активностью, фрагмент выделенной нуклеиновой кислоты, вектор экспрессии (варианты), фармацевтическая композиция для лечения гемофилии A и способ ее лечения
CN101934069A (zh) 脑红蛋白在促进神经元突起生长中的应用
CN118754947B (zh) 一种多肽及其多肽复合物纳米粒、核酸疫苗和应用
JP5789927B2 (ja) 放射線照射コラーゲン様ペプチドを用いた核酸導入法
WO2025110115A1 (ja) Ｃｘｃｌ１２ ｒｎａ配列に基づく新規二本鎖ｒｎａ及びその利用
WO2026028971A1 (ja) Ｒｓｖ－ｂ ｒｎａ配列に基づく新規二本鎖ｒｎａ及びその利用
WO2026063375A1 (ja) Ｒｓｖ ｐタンパク質 ｒｎａ配列に基づく新規二本鎖ｒｎａ及びその利用