JP2024528072A - イミダゾール有機化合物及び炎症性腸疾患に対するその使用 - Google Patents

イミダゾール有機化合物及び炎症性腸疾患に対するその使用 Download PDF

Info

Publication number
JP2024528072A
JP2024528072A JP2024505332A JP2024505332A JP2024528072A JP 2024528072 A JP2024528072 A JP 2024528072A JP 2024505332 A JP2024505332 A JP 2024505332A JP 2024505332 A JP2024505332 A JP 2024505332A JP 2024528072 A JP2024528072 A JP 2024528072A
Authority
JP
Japan
Prior art keywords
alkyl
halo
optionally substituted
methyl
imidazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024505332A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2023007185A5 (https=
JP2024528072A5 (https=
Inventor
アーモンド－シン ジョシュア
ペイシェント リー
アイ．バルモンド エドワード
ロバス ニコラ
ポリドーロ ベリッチ モニカ
Original Assignee
ベネボレンタイ ケンブリッジ リミティド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ベネボレンタイ ケンブリッジ リミティド filed Critical ベネボレンタイ ケンブリッジ リミティド
Publication of JP2024528072A publication Critical patent/JP2024528072A/ja
Publication of JPWO2023007185A5 publication Critical patent/JPWO2023007185A5/ja
Publication of JP2024528072A5 publication Critical patent/JP2024528072A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2024505332A 2021-07-30 2022-07-29 イミダゾール有機化合物及び炎症性腸疾患に対するその使用 Pending JP2024528072A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2111001.0 2021-07-30
GBGB2111001.0A GB202111001D0 (en) 2021-07-30 2021-07-30 Organic compound and their uses
PCT/GB2022/052010 WO2023007185A1 (en) 2021-07-30 2022-07-29 Imidazole organic compounds and their use against inflammatory bowel disease

Publications (3)

Publication Number Publication Date
JP2024528072A true JP2024528072A (ja) 2024-07-26
JPWO2023007185A5 JPWO2023007185A5 (https=) 2025-08-01
JP2024528072A5 JP2024528072A5 (https=) 2025-08-01

Family

ID=77651254

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024505332A Pending JP2024528072A (ja) 2021-07-30 2022-07-29 イミダゾール有機化合物及び炎症性腸疾患に対するその使用

Country Status (5)

Country Link
US (1) US20240343729A1 (https=)
EP (1) EP4377313A1 (https=)
JP (1) JP2024528072A (https=)
GB (1) GB202111001D0 (https=)
WO (1) WO2023007185A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013005798A1 (ja) * 2011-07-06 2013-01-10 持田製薬株式会社 新規含窒素複素環誘導体
WO2013050527A1 (en) * 2011-10-05 2013-04-11 H. Lundbeck A/S Quinazoline derivatives as pde10a enzyme inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013005798A1 (ja) * 2011-07-06 2013-01-10 持田製薬株式会社 新規含窒素複素環誘導体
WO2013050527A1 (en) * 2011-10-05 2013-04-11 H. Lundbeck A/S Quinazoline derivatives as pde10a enzyme inhibitors

Also Published As

Publication number Publication date
WO2023007185A1 (en) 2023-02-02
US20240343729A1 (en) 2024-10-17
GB202111001D0 (en) 2021-09-15
EP4377313A1 (en) 2024-06-05

Similar Documents

Publication Publication Date Title
EP2731948B1 (en) Novel substituted indole derivatives as gamma secretase modulators
US9000186B2 (en) Ring-fused heterocyclic derivative
KR101410453B1 (ko) 소정의 화학 물질, 조성물 및 방법
TWI510487B (zh) 用於激酶調節的化合物和方法及其適應症
US9550796B2 (en) Pyrrolopyrrolone derivatives and their use as BET inhibitors
KR20160012194A (ko) 이미다조피롤리디논 유도체 및 질환의 치료에서의 그의 용도
US10358435B2 (en) Triazolyl pyrimidinone compounds as PDE2 inhibitors
EP3596064B1 (en) Tosylacetate based compounds and derivatives thereof as phgdh inhibitors
JP2024502258A (ja) Ｃｇａｓに関連する状態の処置に有用なインドール誘導体
JP2022511112A (ja) Ａｌｋ５阻害剤としてのナフチリジンおよびキノリン誘導体
JP2015518018A (ja) Ｐｄｅ１０阻害剤としてのトリアゾロ化合物
EP3302484B1 (en) 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors
EP3302486B1 (en) Dihydropyrazolopyrimidinone compounds as pde2 inhibitors
EA036289B1 (ru) Конденсированные трициклические имидазопиразины в качестве ингибиторов активности tnf
US20240066027A1 (en) Novel par-2 inhibitors
US20250320224A1 (en) Novel par-2 inhibitors
US20240336591A1 (en) Organic pyridine-pyrazole compounds and their uses
JP2024528072A (ja) イミダゾール有機化合物及び炎症性腸疾患に対するその使用
EP4313972B1 (en) Indoline derivatives as ddrs inhibitors
US20250026722A1 (en) Substituted quinolines as improved nf-kb-inducing kinase (nik) inhibitors
RU2782375C2 (ru) Новые соединения и их фармацевтические композиции для лечения заболеваний
EA049627B1 (ru) Органические соединения пиридин-пиразола и их использование
WO2025076632A1 (en) Compounds and uses thereof
HK1188116A (en) Ring-fused heterocyclic derivative

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250724

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20250724

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20260319

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20260331