JP2024522692A5 - - Google Patents
Info
- Publication number
- JP2024522692A5 JP2024522692A5 JP2023577160A JP2023577160A JP2024522692A5 JP 2024522692 A5 JP2024522692 A5 JP 2024522692A5 JP 2023577160 A JP2023577160 A JP 2023577160A JP 2023577160 A JP2023577160 A JP 2023577160A JP 2024522692 A5 JP2024522692 A5 JP 2024522692A5
- Authority
- JP
- Japan
- Prior art keywords
- lipid
- alkyl
- pharmaceutically acceptable
- acceptable salt
- peg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163210204P | 2021-06-14 | 2021-06-14 | |
| US63/210,204 | 2021-06-14 | ||
| PCT/US2022/033334 WO2022266032A1 (en) | 2021-06-14 | 2022-06-14 | Cationic lipids and compositions thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024522692A JP2024522692A (ja) | 2024-06-21 |
| JP2024522692A5 true JP2024522692A5 (cg-RX-API-DMAC7.html) | 2025-06-24 |
Family
ID=82547431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023577160A Pending JP2024522692A (ja) | 2021-06-14 | 2022-06-14 | カチオン性脂質及びその組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240293574A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP4355727A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2024522692A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20240023420A (cg-RX-API-DMAC7.html) |
| CN (1) | CN117642380A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2022291742A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3222589A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL309145A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2023014855A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2022266032A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116082184B (zh) * | 2023-04-12 | 2023-06-30 | 山东大学 | 基于环己二胺的可电离脂质、脂质纳米颗粒及其制备方法与应用 |
| AU2024279278A1 (en) | 2023-05-31 | 2025-12-18 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| KR102898792B1 (ko) * | 2023-06-26 | 2025-12-19 | 주식회사 무진메디 | 이온화 가능한 펩타이드를 이용한 지질 나노입자 기반 약물 전달체 및 이의 제조방법 |
| WO2025005632A1 (ko) * | 2023-06-26 | 2025-01-02 | 주식회사 무진메디 | 이온화 가능한 펩타이드를 이용한 지질 나노입자 기반 약물 전달체 및 이의 제조방법 |
| WO2025143892A1 (ko) * | 2023-12-29 | 2025-07-03 | 주식회사 삼양홀딩스 | 약물전달용 나노입자의 조성물 |
| CN117964577B (zh) * | 2024-03-29 | 2024-06-21 | 天津全和诚生物技术有限公司 | 阳离子脂质化合物、其制备方法、包含其的组合物及应用 |
| WO2026003582A2 (en) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipids and lipid nanoparticles |
| CN118634207B (zh) * | 2024-08-15 | 2024-11-26 | 北京悦康科创医药科技股份有限公司 | 一种雾化吸入用核酸-脂质纳米粒及其制备方法和应用 |
| CN118903476B (zh) * | 2024-10-10 | 2025-05-06 | 嘉晨西海(南昌)生物制药有限公司 | 含LNP和mRNA的组合物及其在治疗戈谢病中的应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| AU733310C (en) | 1997-05-14 | 2001-11-29 | University Of British Columbia, The | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US7201898B2 (en) | 2000-06-01 | 2007-04-10 | The University Of North Carolina At Chapel Hill | Methods and compounds for controlled release of recombinant parvovirus vectors |
| WO2002087541A1 (en) | 2001-04-30 | 2002-11-07 | Protiva Biotherapeutics Inc. | Lipid-based formulations for gene transfer |
| EP1519714B1 (en) | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| EP1664316B1 (en) | 2003-09-15 | 2012-08-29 | Protiva Biotherapeutics Inc. | Polyethyleneglycol-modified lipid compounds and uses thereof |
| US7404969B2 (en) | 2005-02-14 | 2008-07-29 | Sirna Therapeutics, Inc. | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules |
| CN101267805A (zh) | 2005-07-27 | 2008-09-17 | 普洛体维生物治疗公司 | 制造脂质体的系统和方法 |
| CA2689042A1 (en) | 2007-02-16 | 2008-08-28 | Merck & Co., Inc. | Compositions and methods for potentiated activity of biologicaly active molecules |
| WO2009086558A1 (en) | 2008-01-02 | 2009-07-09 | Tekmira Pharmaceuticals Corporation | Improved compositions and methods for the delivery of nucleic acids |
| CA2721333C (en) | 2008-04-15 | 2020-12-01 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for nucleic acid delivery |
| US20130037977A1 (en) | 2010-04-08 | 2013-02-14 | Paul A. Burke | Preparation of Lipid Nanoparticles |
| US20130156845A1 (en) | 2010-04-29 | 2013-06-20 | Alnylam Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
| WO2012024526A2 (en) | 2010-08-20 | 2012-02-23 | Cerulean Pharma Inc. | Conjugates, particles, compositions, and related methods |
| EP3485875A1 (en) | 2011-11-04 | 2019-05-22 | Nitto Denko Corporation | Single use system for sterelily producing lipid-nucleic acid particles |
| TW201808342A (zh) | 2012-05-02 | 2018-03-16 | 喜納製藥公司 | 包含四ｇａｌｎａｃ之新穎結合物及傳送寡核苷酸之方法 |
| CN105085292B (zh) * | 2014-05-23 | 2017-12-15 | 上海交通大学 | 3‑((2‑(二甲氨基)乙烷基)(甲基)氨基)丙酸的两亲性衍生物及其用途 |
| PT3313829T (pt) | 2015-06-29 | 2024-07-08 | Acuitas Therapeutics Inc | Formulações de lípidos e de nanopartículas lipídicas para a administração de ácidos nucleicos |
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| HRP20230209T1 (hr) | 2015-10-28 | 2023-04-14 | Acuitas Therapeutics Inc. | Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina |
| BR112018003910B1 (pt) | 2015-11-16 | 2022-03-22 | F. Hoffmann-La Roche Ag | Derivado de fosforamidita galnac, processo para a preparação de um derivado de fosforamidita galnac de fórmula i e uso dos derivados de fosforamidita galnac de fórmula i |
| PL3386484T3 (pl) | 2015-12-10 | 2022-07-25 | Modernatx, Inc. | Kompozycje i sposoby dostarczania środków terapeutycznych |
| JP7194594B2 (ja) * | 2016-05-18 | 2022-12-22 | モデルナティエックス インコーポレイテッド | 免疫調節ポリペプチドをコードするｍＲＮＡの組み合わせ及びその使用 |
| MA45036A (fr) * | 2016-05-18 | 2019-03-27 | Modernatx Inc | Polynucléotides codant pour la citrine pour le traitement de la citrullinémie de type 2 |
| EP4186888B1 (en) * | 2017-03-15 | 2025-11-26 | ModernaTX, Inc. | Compound and compositions for intracellular delivery of therapeutic agents |
| JP7630904B2 (ja) * | 2019-07-23 | 2025-02-18 | 株式会社東芝 | 核酸導入キャリア、核酸導入キャリアセット、核酸導入組成物及び核酸導入方法 |
| WO2021046265A1 (en) * | 2019-09-06 | 2021-03-11 | Generation Bio Co. | Lipid nanoparticle compositions comprising closed-ended dna and cleavable lipids and methods of use thereof |
| WO2021092194A1 (en) * | 2019-11-05 | 2021-05-14 | Vicarious Surgical Inc. | Surgical virtual reality user interface |
| JP2023502576A (ja) * | 2019-11-22 | 2023-01-25 | ジェネレーション バイオ カンパニー | イオン化可能な脂質およびそれらのナノ粒子組成物 |
| KR20230034333A (ko) * | 2020-07-02 | 2023-03-09 | 라이프 테크놀로지스 코포레이션 | 트리뉴클레오티드 캡 유사체, 제조 및 이의 용도 |
| AU2021307952A1 (en) * | 2020-07-17 | 2023-03-02 | Generation Bio Co. | Methods for encapsulating polynucleotides into reduced sizes of Lipid nanoparticles and novel formulation thereof |
-
2022
- 2022-06-14 AU AU2022291742A patent/AU2022291742A1/en active Pending
- 2022-06-14 KR KR1020247001308A patent/KR20240023420A/ko active Pending
- 2022-06-14 JP JP2023577160A patent/JP2024522692A/ja active Pending
- 2022-06-14 IL IL309145A patent/IL309145A/en unknown
- 2022-06-14 CA CA3222589A patent/CA3222589A1/en active Pending
- 2022-06-14 CN CN202280049199.XA patent/CN117642380A/zh active Pending
- 2022-06-14 WO PCT/US2022/033334 patent/WO2022266032A1/en not_active Ceased
- 2022-06-14 EP EP22741620.3A patent/EP4355727A1/en active Pending
- 2022-06-14 US US18/569,623 patent/US20240293574A1/en active Pending
- 2022-06-14 MX MX2023014855A patent/MX2023014855A/es unknown
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