JP2024522167A - 肝疾患の処置のための併用療法 - Google Patents

肝疾患の処置のための併用療法 Download PDF

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JP2024522167A
JP2024522167A JP2023575549A JP2023575549A JP2024522167A JP 2024522167 A JP2024522167 A JP 2024522167A JP 2023575549 A JP2023575549 A JP 2023575549A JP 2023575549 A JP2023575549 A JP 2023575549A JP 2024522167 A JP2024522167 A JP 2024522167A
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seq
pnpla3
receptor
glp
inhibitor
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JP2024522167A5 (enExample
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リンデン，ダニエル
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AstraZeneca AB
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AstraZeneca AB
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K38/22—Hormones
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01002—Arylesterase (3.1.1.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/33—Chemical structure of the base
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
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    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01051—1-Acylglycerol-3-phosphate O-acyltransferase (2.3.1.51)

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JP2023575549A 2021-06-08 2022-06-07 肝疾患の処置のための併用療法 Withdrawn JP2024522167A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163208299P 2021-06-08 2021-06-08
US63/208,299 2021-06-08
PCT/IB2022/055292 WO2022259145A1 (en) 2021-06-08 2022-06-07 Combination therapies for treatment of liver diseases

Publications (2)

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JP2024522167A true JP2024522167A (ja) 2024-06-11
JP2024522167A5 JP2024522167A5 (enExample) 2025-06-13

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JP2023575549A Withdrawn JP2024522167A (ja) 2021-06-08 2022-06-07 肝疾患の処置のための併用療法

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US (1) US20250122504A1 (enExample)
EP (1) EP4352223A1 (enExample)
JP (1) JP2024522167A (enExample)
KR (1) KR20240019796A (enExample)
CN (1) CN117441017A (enExample)
AU (1) AU2022289514A1 (enExample)
CA (1) CA3221482A1 (enExample)
IL (1) IL308974A (enExample)
MX (1) MX2023014723A (enExample)
TW (1) TW202313974A (enExample)
WO (1) WO2022259145A1 (enExample)
ZA (1) ZA202400228B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4724472A2 (en) * 2023-06-09 2026-04-15 Sun Pharmaceutical Industries Limited Glp-1/gip dual, glp-1/gcg dual and glp-1/gip/gcg triple receptor agonists
TW202539705A (zh) * 2024-04-03 2025-10-16 瑞典商阿斯特捷利康公司 Ｐｎｐｌａ３表現之抑制劑的劑量依賴性投予

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
EP0401384B1 (en) 1988-12-22 1996-03-13 Kirin-Amgen, Inc. Chemically modified granulocyte colony stimulating factor
US8563521B2 (en) 2007-06-21 2013-10-22 Technische Universitat Munchen Biological active proteins having increased in vivo and/or in vitro stability
TWI617574B (zh) 2012-12-11 2018-03-11 梅迪繆思有限公司 用於治療肥胖之升糖素與ｇｌｐ－１共促效劑
TWI869213B (zh) * 2018-09-19 2025-01-01 美商Ionis製藥公司 Pnpla3表現之調節劑
CN114728017B (zh) * 2019-10-14 2025-10-28 阿斯利康(瑞典)有限公司 Pnpla3表达的调节剂
CN115176007A (zh) * 2019-12-16 2022-10-11 阿尔尼拉姆医药品有限公司 含类PATATIN磷脂酶结构域3(PNPLA3)iRNA组合物及其使用方法

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Publication number Publication date
TW202313974A (zh) 2023-04-01
EP4352223A1 (en) 2024-04-17
US20250122504A1 (en) 2025-04-17
KR20240019796A (ko) 2024-02-14
WO2022259145A1 (en) 2022-12-15
ZA202400228B (en) 2024-09-25
MX2023014723A (es) 2024-01-16
CN117441017A (zh) 2024-01-23
AU2022289514A1 (en) 2024-01-25
CA3221482A1 (en) 2022-12-15
IL308974A (en) 2024-01-01

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