JP2024522163A - シアル酸結合リガンドを含む新規の粒子組成物 - Google Patents

シアル酸結合リガンドを含む新規の粒子組成物 Download PDF

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Publication number
JP2024522163A
JP2024522163A JP2023575488A JP2023575488A JP2024522163A JP 2024522163 A JP2024522163 A JP 2024522163A JP 2023575488 A JP2023575488 A JP 2023575488A JP 2023575488 A JP2023575488 A JP 2023575488A JP 2024522163 A JP2024522163 A JP 2024522163A
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JP
Japan
Prior art keywords
solvent
acid
particle
sialic acid
composition
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JP2023575488A
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English (en)
Japanese (ja)
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JP2024522163A5 (https=
Inventor
ウー，ビン
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サイトダイム，インコーポレイテッド
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Publication of JP2024522163A5 publication Critical patent/JP2024522163A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
JP2023575488A 2021-06-08 2022-06-08 シアル酸結合リガンドを含む新規の粒子組成物 Pending JP2024522163A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163208150P 2021-06-08 2021-06-08
US63/208,150 2021-06-08
PCT/US2022/032674 WO2022261207A1 (en) 2021-06-08 2022-06-08 Novel particle composition comprising sialic acid binding ligand

Publications (2)

Publication Number Publication Date
JP2024522163A true JP2024522163A (ja) 2024-06-11
JP2024522163A5 JP2024522163A5 (https=) 2025-06-17

Family

ID=84426331

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023575488A Pending JP2024522163A (ja) 2021-06-08 2022-06-08 シアル酸結合リガンドを含む新規の粒子組成物

Country Status (7)

Country Link
US (1) US20240358653A1 (https=)
EP (1) EP4351520A4 (https=)
JP (1) JP2024522163A (https=)
CN (1) CN117750946A (https=)
AU (1) AU2022289003A1 (https=)
CA (1) CA3221371A1 (https=)
WO (1) WO2022261207A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118178673B (zh) * 2024-04-07 2024-11-05 铭畅生物医药南通有限公司 一种唾液酸酯环糊精包合物及其制备方法和用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080138430A1 (en) * 2006-09-27 2008-06-12 Owens Donald E Temperature-Sensitive Nanoparticles for Controlled Drug Delivery
JP2012506900A (ja) * 2008-10-28 2012-03-22 ウニベルシダーデ デ サンティアゴ デ コンポステラ アニオン性ポリマーから調製されるナノ粒子系
US20120294904A1 (en) * 2011-05-19 2012-11-22 Syracuse University Polysialic acid-based n-trimethyl chitosan gel nanoparticles for systemic drug delivery
WO2020243248A1 (en) * 2019-05-28 2020-12-03 Phosphorex, Inc. Microparticles and nanoparticles having sulfate groups on the surface

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009539793A (ja) * 2006-06-08 2009-11-19 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 診断及び治療用途のための官能化された固体ポリマーナノ粒子
US20100009007A1 (en) * 2008-07-10 2010-01-14 Baxter International Inc. Non-covalent modification of microparticles and process of preparing same
GB0922066D0 (en) * 2009-12-17 2010-02-03 Univ Belfast Modulator
ES2711669A1 (es) * 2017-11-02 2019-05-06 Univ Santiago Compostela Sistemas de liberacion de farmacos de acido polisialico y metodos

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080138430A1 (en) * 2006-09-27 2008-06-12 Owens Donald E Temperature-Sensitive Nanoparticles for Controlled Drug Delivery
JP2012506900A (ja) * 2008-10-28 2012-03-22 ウニベルシダーデ デ サンティアゴ デ コンポステラ アニオン性ポリマーから調製されるナノ粒子系
US20120294904A1 (en) * 2011-05-19 2012-11-22 Syracuse University Polysialic acid-based n-trimethyl chitosan gel nanoparticles for systemic drug delivery
WO2020243248A1 (en) * 2019-05-28 2020-12-03 Phosphorex, Inc. Microparticles and nanoparticles having sulfate groups on the surface

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIOMATERIALS, vol. 31, JPN6026012058, 2010, pages 3395 - 3403, ISSN: 0005826446 *

Also Published As

Publication number Publication date
AU2022289003A1 (en) 2023-12-21
US20240358653A1 (en) 2024-10-31
WO2022261207A1 (en) 2022-12-15
CA3221371A1 (en) 2022-12-15
EP4351520A4 (en) 2025-04-02
EP4351520A1 (en) 2024-04-17
CN117750946A (zh) 2024-03-22

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