JP2024520868A5 - - Google Patents
Info
- Publication number
- JP2024520868A5 JP2024520868A5 JP2023577405A JP2023577405A JP2024520868A5 JP 2024520868 A5 JP2024520868 A5 JP 2024520868A5 JP 2023577405 A JP2023577405 A JP 2023577405A JP 2023577405 A JP2023577405 A JP 2023577405A JP 2024520868 A5 JP2024520868 A5 JP 2024520868A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- acid sequence
- amino acid
- polypeptide chain
- binds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024093451A JP2024116283A (ja) | 2021-06-15 | 2024-06-10 | Ｃｌｄｎ１８．２及びｃｄ３に結合する二重特異性結合剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2021/066141 WO2022262959A1 (en) | 2021-06-15 | 2021-06-15 | Bispecific binding agents binding to cldn18.2 and cd3 |
| EPPCT/EP2021/066141 | 2021-06-15 | ||
| PCT/EP2022/066299 WO2022263508A1 (en) | 2021-06-15 | 2022-06-15 | Bispecific binding agents binding to cldn18.2 and cd3 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024093451A Division JP2024116283A (ja) | 2021-06-15 | 2024-06-10 | Ｃｌｄｎ１８．２及びｃｄ３に結合する二重特異性結合剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024520868A JP2024520868A (ja) | 2024-05-24 |
| JP2024520868A5 true JP2024520868A5 (enExample) | 2024-06-18 |
| JP7513854B2 JP7513854B2 (ja) | 2024-07-09 |
Family
ID=77519090
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023577405A Active JP7513854B2 (ja) | 2021-06-15 | 2022-06-15 | Ｃｌｄｎ１８．２及びｃｄ３に結合する二重特異性結合剤 |
| JP2024093451A Pending JP2024116283A (ja) | 2021-06-15 | 2024-06-10 | Ｃｌｄｎ１８．２及びｃｄ３に結合する二重特異性結合剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024093451A Pending JP2024116283A (ja) | 2021-06-15 | 2024-06-10 | Ｃｌｄｎ１８．２及びｃｄ３に結合する二重特異性結合剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11739145B2 (enExample) |
| EP (1) | EP4355428A1 (enExample) |
| JP (2) | JP7513854B2 (enExample) |
| KR (1) | KR20240032847A (enExample) |
| CN (1) | CN117858906A (enExample) |
| AR (1) | AR126154A1 (enExample) |
| AU (1) | AU2022292895A1 (enExample) |
| BR (1) | BR112023026566A2 (enExample) |
| CA (1) | CA3222300A1 (enExample) |
| CL (1) | CL2023003725A1 (enExample) |
| CO (1) | CO2023017378A2 (enExample) |
| IL (1) | IL308072A (enExample) |
| MX (1) | MX2023014666A (enExample) |
| TW (1) | TW202317624A (enExample) |
| WO (2) | WO2022262959A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018054484A1 (en) * | 2016-09-23 | 2018-03-29 | Biontech Ag | Bispecific trivalent antibodies binding to claudin 6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases |
| AU2020379735A1 (en) | 2019-11-05 | 2022-05-26 | Regeneron Pharmaceuticals, Inc. | N-terminal SCFV multispecific binding molecules |
| JP2026501506A (ja) * | 2022-12-14 | 2026-01-16 | アステラス・ファーマ・ヨーロッパ・ベスローデン・フェンノートシャップ | Ｃｌｄｎ１８．２及びｃｄ３に結合する二重特異性結合剤並びに免疫チェックポイント阻害剤を含む併用療法 |
| WO2025120866A1 (en) * | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| AR134560A1 (es) * | 2023-12-08 | 2026-01-28 | Astellas Pharma Inc | Terapia de combinación que implica agentes de unión biespecíficos que se unen a cldn18.2 y cd3 y agentes que estabilizan o aumentan la expresión de cldn18.2 |
| WO2025120867A1 (en) * | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies |
| CN120829517A (zh) * | 2024-04-22 | 2025-10-24 | 鲁南新时代生物技术有限公司 | 抗cldn18.2/cd3双特异性抗体及用途 |
| WO2026060339A1 (en) * | 2024-09-16 | 2026-03-19 | Merck Sharp & Dohme Llc | Human claudin 18.2 binders and uses thereof |
| WO2026101943A1 (en) * | 2024-11-06 | 2026-05-15 | Agilent Technologies, Inc. | Anti-human claudin-18.2 antibodies for in vitro diagnostics |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| GB9203459D0 (en) | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| KR100944575B1 (ko) | 2002-10-17 | 2010-02-25 | 젠맵 에이/에스 | Ｃｄ20에 대한 인간 모노클로날 항체 |
| JP2007512846A (ja) | 2003-12-04 | 2007-05-24 | ゼンコー・インコーポレイテッド | 増加した宿主ストリング含有量を有する変異体タンパク質の生成方法およびその組成物 |
| EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| US20090004213A1 (en) | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
| US9856320B2 (en) | 2012-05-15 | 2018-01-02 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting PD-1/PD-L1 signaling |
| KR102391731B1 (ko) | 2013-01-14 | 2022-04-27 | 젠코어 인코포레이티드 | 신규한 이형이량체 단백질 |
| JP6696982B2 (ja) * | 2014-11-26 | 2020-05-20 | ゼンコー・インコーポレイテッドＸｅｎｃｏｒ、 Ｉｎｃ． | Ｃｄ３および腫瘍抗原に結合するヘテロ二量体抗体 |
| WO2018054484A1 (en) * | 2016-09-23 | 2018-03-29 | Biontech Ag | Bispecific trivalent antibodies binding to claudin 6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases |
| CN111518214B (zh) * | 2019-02-03 | 2023-09-22 | 上海健信生物医药科技有限公司 | 靶向cldn18.2的双特异性抗体及其制备方法和应用 |
| BR112021002032A2 (pt) | 2018-08-03 | 2021-07-20 | Amgen Research (Munich) Gmbh | construtos de anticorpos para cldn18.2 e cd3 |
| WO2021237717A1 (zh) * | 2020-05-29 | 2021-12-02 | 武汉友芝友生物制药有限公司 | 抗cldn18.2和cd3的双特异性抗体 |
-
2021
- 2021-06-15 WO PCT/EP2021/066141 patent/WO2022262959A1/en not_active Ceased
-
2022
- 2022-06-15 KR KR1020247001571A patent/KR20240032847A/ko active Pending
- 2022-06-15 MX MX2023014666A patent/MX2023014666A/es unknown
- 2022-06-15 CN CN202280042413.9A patent/CN117858906A/zh active Pending
- 2022-06-15 IL IL308072A patent/IL308072A/en unknown
- 2022-06-15 JP JP2023577405A patent/JP7513854B2/ja active Active
- 2022-06-15 TW TW111122151A patent/TW202317624A/zh unknown
- 2022-06-15 AU AU2022292895A patent/AU2022292895A1/en active Pending
- 2022-06-15 WO PCT/EP2022/066299 patent/WO2022263508A1/en not_active Ceased
- 2022-06-15 AR ARP220101578A patent/AR126154A1/es unknown
- 2022-06-15 EP EP22750661.5A patent/EP4355428A1/en active Pending
- 2022-06-15 BR BR112023026566A patent/BR112023026566A2/pt unknown
- 2022-06-15 CA CA3222300A patent/CA3222300A1/en active Pending
- 2022-12-06 US US18/062,465 patent/US11739145B2/en active Active
-
2023
- 2023-07-05 US US18/347,361 patent/US12378313B2/en active Active
- 2023-12-13 CL CL2023003725A patent/CL2023003725A1/es unknown
- 2023-12-14 CO CONC2023/0017378A patent/CO2023017378A2/es unknown
-
2024
- 2024-06-10 JP JP2024093451A patent/JP2024116283A/ja active Pending
-
2025
- 2025-07-11 US US19/267,078 patent/US20260035458A1/en active Pending