JP2024519737A - Ａｄｐリボシル基またはそのポリマーへの結合を検出する方法および同方法を実施するためのキット - Google Patents

Ａｄｐリボシル基またはそのポリマーへの結合を検出する方法および同方法を実施するためのキット Download PDF

Info

Publication number
JP2024519737A
JP2024519737A JP2023568450A JP2023568450A JP2024519737A JP 2024519737 A JP2024519737 A JP 2024519737A JP 2023568450 A JP2023568450 A JP 2023568450A JP 2023568450 A JP2023568450 A JP 2023568450A JP 2024519737 A JP2024519737 A JP 2024519737A
Authority
JP
Japan
Prior art keywords
adp
protein
entity
binding
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023568450A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024519737A5 (enExample
Inventor
レーティオ ラリ
ソワ スヴェン
ガレラ－プラット アルベルト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OULUN YLIOPISTO
Original Assignee
OULUN YLIOPISTO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OULUN YLIOPISTO filed Critical OULUN YLIOPISTO
Publication of JP2024519737A publication Critical patent/JP2024519737A/ja
Publication of JP2024519737A5 publication Critical patent/JP2024519737A5/ja
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/0203—NAD+ ADP-ribosyltransferase (2.4.2.30), i.e. tankyrase or poly(ADP-ribose) polymerase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/235—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Bordetella (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91091—Glycosyltransferases (2.4)
    • G01N2333/91142—Pentosyltransferases (2.4.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/38—Post-translational modifications [PTMs] in chemical analysis of biological material addition of carbohydrates, e.g. glycosylation, glycation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
JP2023568450A 2021-05-06 2022-05-06 Ａｄｐリボシル基またはそのポリマーへの結合を検出する方法および同方法を実施するためのキット Pending JP2024519737A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20215539 2021-05-06
FI20215539 2021-05-06
PCT/FI2022/050305 WO2022234194A1 (en) 2021-05-06 2022-05-06 Method for detecting binding to an adp-ribosyl group or a polymer thereof and a kit for performing said method

Publications (2)

Publication Number Publication Date
JP2024519737A true JP2024519737A (ja) 2024-05-21
JP2024519737A5 JP2024519737A5 (enExample) 2025-05-01

Family

ID=81648183

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023568450A Pending JP2024519737A (ja) 2021-05-06 2022-05-06 Ａｄｐリボシル基またはそのポリマーへの結合を検出する方法および同方法を実施するためのキット

Country Status (4)

Country Link
US (1) US20240241113A1 (enExample)
EP (1) EP4334720A1 (enExample)
JP (1) JP2024519737A (enExample)
WO (1) WO2022234194A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116970679B (zh) * 2023-09-19 2023-12-19 杭州圣域生物医药科技有限公司 一种高通量筛选adp核糖水解酶抑制剂的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010510771A (ja) * 2006-11-27 2010-04-08 シ ビオ アンテルナショナル 翻訳後修飾の検出のための方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010510771A (ja) * 2006-11-27 2010-04-08 シ ビオ アンテルナショナル 翻訳後修飾の検出のための方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JIM VOORNEVELD ET AL.: "Molecular Tools for the Study of ADP-Ribosylation: A Unified and Versatile Method to Synthesise Nati", CHEMISTRY-A EUROPEAN JOURNAL, vol. 27, JPN6026016520, 26 March 2021 (2021-03-26), pages 10621 - 10627, ISSN: 0005849628 *
MARION SCHULLER ET AL.: "Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-R", ACS CHEMICAL BIOLOGY, vol. 12, no. 11, JPN6026016518, 9 October 2017 (2017-10-09), pages 2866 - 2874, ISSN: 0005849625 *
MICHAEL S COHEN & PAUL CHANG: "Insights into the biogenesis, function, and regulation of ADP-ribosylation", NATURE CHEMICAL BIOLOGY, vol. 14, JPN6026016519, 14 February 2018 (2018-02-14), pages 236 - 243, ISSN: 0005849627 *
TORUN EKBLAD ET AL.: "Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol", SLAS DISCOVERY: ADVANCING THE SCIENCE OF DRUG DISCOVERY, vol. 23, no. 4, JPN6026016522, 9 January 2018 (2018-01-09), pages 353 - 362, ISSN: 0005849626 *
VILLE ESKONEN ET AL.: "Single-Peptide TR-FRET Detection Platform for Cysteine-Specific Post-Translational Modifications", ANALYTICAL CHEMISTRY, vol. 92, no. 19, JPN6026016521, 2 September 2020 (2020-09-02), pages 13202 - 13210, ISSN: 0005849629 *

Also Published As

Publication number Publication date
US20240241113A1 (en) 2024-07-18
WO2022234194A1 (en) 2022-11-10
EP4334720A1 (en) 2024-03-13

Similar Documents

Publication Publication Date Title
JP7532562B2 (ja) 構造的相補性による生物発光の活性化
CN104871001B (zh) 使用细胞内生物发光共振能量转移识别生物活性剂的细胞靶标结合
JP4195815B2 (ja) Ｏ６−アルキルグアニン−ｄｎａアルキルトランスフェラーゼ（ａｇｔ）の使用方法
JP2026041741A (ja) 多分子ルシフェラーゼ
US12241839B2 (en) Multipartite luciferase peptides and polypeptides
JP2007509608A (ja) アシル担体タンパク質に基づくタンパク質をラベルするための方法
JP2004532028A5 (enExample)
Banala et al. No washing, less waiting: engineering biomolecular reporters for single-step antibody detection in solution
CA2731981A1 (en) Antibody complex, method for detecting antigen, and method for producing antibody complex
US20240241113A1 (en) Method for detecting binding to an ADP-ribosyl group or a polymer thereof and a kit for performing said method
JPWO2008117792A1 (ja) アデノシン三リン酸測定のための蛍光標識融合タンパク質
KR101510513B1 (ko) 신규한 양자점-앱타머 결합체 및 이의 용도
KR101970963B1 (ko) 황열 바이러스 ediii에 특이적으로 결합하는 dna 압타머 및 이의 용도
Adhikari et al. Advancing Biomarker Detection with Peptide‐Integrated Fluorescent Probes
Hirano et al. Development of Novel Fluorescent Sensors Based on Fluorescent Natural Compounds
US20230035412A1 (en) Detection of analyte
Krasitskaya et al. Development and Characterization of Novel DNA Aptamers Specific to Heart-Type Fatty Acid Binding Protein (hFABP)
IT202200025416A1 (it) Biosensore per la rilevazione di particelle virali
US20230303635A1 (en) Diagnostic methods and compositions
WO2026011125A1 (en) Genetically encoded light-up sensors
PL243470B1 (pl) Sposób identyfikacji niskocząsteczkowych związków indukujących powstawanie kompleksu trójskładnikowego oraz test płytkowy wykorzystujący taki sposób
Zakeri et al. Peptide targeting by spontaneous isopeptide bond formation
Kostecki An Application Of Bimolecular Fluorescence Complementation (Bifc) For The Detection And Analysis Of Protein Interactions Along The Escherichia Coli Twin Arginine Translocation (Tat) Pathway
Gaiotto Engineering of coiled-coil protein scaffolds as innovative tools for biosensing applications

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250422

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20250422

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20260327

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20260428