JP2024517871A - プロテアーゼ活性化治療剤を含む組成物および方法 - Google Patents

プロテアーゼ活性化治療剤を含む組成物および方法 Download PDF

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JP2024517871A
JP2024517871A JP2023568310A JP2023568310A JP2024517871A JP 2024517871 A JP2024517871 A JP 2024517871A JP 2023568310 A JP2023568310 A JP 2023568310A JP 2023568310 A JP2023568310 A JP 2023568310A JP 2024517871 A JP2024517871 A JP 2024517871A
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polypeptide
seq
aspects
linker
tumor
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JP2024517871A5 (enExample
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ジェフリー ハベル
純 石原
ジュアン メンドーサ
アスラン マンスロフ
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University of Chicago
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University of Chicago
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2023568310A 2021-05-07 2022-05-05 プロテアーゼ活性化治療剤を含む組成物および方法 Pending JP2024517871A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163185941P 2021-05-07 2021-05-07
US63/185,941 2021-05-07
US202263313087P 2022-02-23 2022-02-23
US63/313,087 2022-02-23
PCT/US2022/072121 WO2022236292A2 (en) 2021-05-07 2022-05-05 Compositions and methods comprising protease-activated therapeutic agents

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JP2024517871A true JP2024517871A (ja) 2024-04-23
JP2024517871A5 JP2024517871A5 (enExample) 2025-05-15

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US (1) US20240228586A1 (enExample)
EP (1) EP4333873A4 (enExample)
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Publication number Priority date Publication date Assignee Title
BR112022001320A2 (pt) * 2019-07-25 2022-04-12 Univ Chicago Composições e métodos compreendendo agentes terapêuticos ativados por protease
WO2021127487A2 (en) 2019-12-20 2021-06-24 Regeneron Pharmaceuticals, Inc. Novel il2 agonists and methods of use thereof
AU2022314734A1 (en) 2021-07-19 2024-02-08 Regeneron Pharmaceuticals, Inc. Il12 receptor agonists and methods of use thereof
EP4704979A1 (en) * 2023-01-20 2026-03-11 Boehringer Ingelheim International GmbH Il-12 fc fusion proteins
WO2025242835A1 (en) * 2024-05-22 2025-11-27 Ose Immunotherapeutics Molecules comprising masking linkers and uses thereof for the treatment of cancer
WO2025242836A1 (en) * 2024-05-22 2025-11-27 Ose Immunotherapeutics Molecules comprising masking linkers and uses thereof for the treatment of auto-immune or inflammatory diseases and disorders

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US8969027B2 (en) * 2008-03-03 2015-03-03 Kansas State University Research Foundation Protease assay
WO2016023040A1 (en) * 2014-08-08 2016-02-11 Alexo Therapeutics International Sirp-alpha variant constructs and uses thereof
WO2019222296A1 (en) * 2018-05-14 2019-11-21 Werewolf Therapeutics, Inc. Activatable interleukin 12 polypeptides and methods of use thereof
BR112022001320A2 (pt) * 2019-07-25 2022-04-12 Univ Chicago Composições e métodos compreendendo agentes terapêuticos ativados por protease
AU2020353235A1 (en) * 2019-09-28 2022-03-31 AskGene Pharma, Inc. Cytokine prodrugs and dual-prodrugs

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WO2022236292A3 (en) 2022-12-15
US20240228586A1 (en) 2024-07-11
WO2022236292A2 (en) 2022-11-10
EP4333873A2 (en) 2024-03-13

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