JP2024517843A - ステレオシリン二重ベクター系を使用して感音性難聴を治療するための組成物及び方法 - Google Patents

ステレオシリン二重ベクター系を使用して感音性難聴を治療するための組成物及び方法 Download PDF

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JP2024517843A
JP2024517843A JP2023568104A JP2023568104A JP2024517843A JP 2024517843 A JP2024517843 A JP 2024517843A JP 2023568104 A JP2023568104 A JP 2023568104A JP 2023568104 A JP2023568104 A JP 2023568104A JP 2024517843 A JP2024517843 A JP 2024517843A
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vector
seq
sequence
stereocillin
polynucleotide
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JP2024517843A5 (https=
Inventor
バーンズ、ジョセフ
シュワンダー、マーティン
ウー、シュドン
ベッカー、ラーズ
ギブソン、タイラー
パン、ニン
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Decibel Therapeutics Inc
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Decibel Therapeutics Inc
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    • A—HUMAN NECESSITIES
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JP2023568104A 2021-05-05 2022-05-05 ステレオシリン二重ベクター系を使用して感音性難聴を治療するための組成物及び方法 Pending JP2024517843A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163184737P 2021-05-05 2021-05-05
US63/184,737 2021-05-05
PCT/US2022/027870 WO2022235933A2 (en) 2021-05-05 2022-05-05 Compositions and methods for treating sensorineural hearing loss using stereocilin dual vector systems

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JP2024517843A true JP2024517843A (ja) 2024-04-23
JP2024517843A5 JP2024517843A5 (https=) 2025-05-08

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US (1) US20240216540A1 (https=)
EP (1) EP4333905A4 (https=)
JP (1) JP2024517843A (https=)
KR (1) KR20240021166A (https=)
CN (1) CN117750983A (https=)
AU (1) AU2022271265A1 (https=)
BR (1) BR112023022833A2 (https=)
CA (1) CA3219054A1 (https=)
CL (1) CL2023003260A1 (https=)
CO (1) CO2023016804A2 (https=)
IL (1) IL308142A (https=)
MX (1) MX2023013053A (https=)
WO (1) WO2022235933A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020014625A1 (en) 2018-07-13 2020-01-16 Akouos, Inc. Methods of treating non-syndromic sensorineural hearing loss
US20220054640A1 (en) * 2018-12-11 2022-02-24 Decibel Therapeutics, Inc. Compositions and methods for the delivery of therapeutic agents across the round window membrane
CN116925239B (zh) * 2023-07-17 2024-10-18 苏州星奥拓维生物技术有限公司 双载体系统表达Otof基因的组合物和方法
US20260027327A1 (en) 2024-07-26 2026-01-29 Regeneron Pharmaceuticals, Inc. Otic drug delivery system and methods

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020014625A1 (en) * 2018-07-13 2020-01-16 Akouos, Inc. Methods of treating non-syndromic sensorineural hearing loss

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
WO2008073303A2 (en) * 2006-12-07 2008-06-19 Switchgear Genomics Transcriptional regulatory elements of biological pathways, tools, and methods
WO2020077295A1 (en) * 2018-10-11 2020-04-16 Decibel Therapeutics, Inc. Aav1 vectors and uses thereof for treatment of otic indications
EP3880827A4 (en) * 2018-11-07 2023-04-26 Akouos, Inc. COMPOSITIONS AND METHODS FOR INDUCING DIFFERENTIATION OF A HAIR CELL
EP3921032A4 (en) * 2019-02-08 2022-11-30 Decibel Therapeutics, Inc. COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2020014625A1 (en) * 2018-07-13 2020-01-16 Akouos, Inc. Methods of treating non-syndromic sensorineural hearing loss

Non-Patent Citations (4)

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Title
"Accession No.AC004983.3", DATABASE GENBANK, JPN6024039947, 15 October 2003 (2003-10-15), ISSN: 0005802396 *
"Accession No.AC121917.2", DATABASE GENBANK, JPN6024039948, 5 November 2003 (2003-11-05), ISSN: 0005802395 *
GENE THERAPY, vol. 27, JPN6026007095, 2020, pages 329 - 337, ISSN: 0005802393 *
GRACE B ATHAS; ET AL: "IN VITRO ANALYSIS OF THE ONCOMODULIN PROMOTER FOR TARGETING GENE EXPRESSION TO THE EAR", OTOLARYNGOLOGY-HEAD AND NECK SURGERY, vol. VOL:121, SUPPL:2, JPN5023002090, August 1999 (1999-08-01), pages 64 - 65, ISSN: 0005802394 *

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US20240216540A1 (en) 2024-07-04
KR20240021166A (ko) 2024-02-16
CA3219054A1 (en) 2022-11-10
MX2023013053A (es) 2024-01-12
CN117750983A (zh) 2024-03-22
AU2022271265A1 (en) 2023-12-14
BR112023022833A2 (pt) 2024-02-15
EP4333905A4 (en) 2025-03-26
WO2022235933A8 (en) 2023-02-02
WO2022235933A2 (en) 2022-11-10
EP4333905A2 (en) 2024-03-13
AU2022271265A9 (en) 2024-01-25
CO2023016804A2 (es) 2024-02-26
IL308142A (en) 2023-12-01
WO2022235933A3 (en) 2022-12-29
CL2023003260A1 (es) 2024-05-31

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