CN117750983A - 用于使用硬纤毛蛋白双重载体系统治疗感觉神经性听力损失的组合物和方法 - Google Patents

用于使用硬纤毛蛋白双重载体系统治疗感觉神经性听力损失的组合物和方法 Download PDF

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Publication number
CN117750983A
CN117750983A CN202280047724.4A CN202280047724A CN117750983A CN 117750983 A CN117750983 A CN 117750983A CN 202280047724 A CN202280047724 A CN 202280047724A CN 117750983 A CN117750983 A CN 117750983A
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China
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leu
sequence
seq
vector
pro
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CN202280047724.4A
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English (en)
Chinese (zh)
Inventor
J·伯恩斯
M·施万德
X·吴
L·贝克尔
T·吉布森
N·潘
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Decibel Therapeutics Inc
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Decibel Therapeutics Inc
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Publication of CN117750983A publication Critical patent/CN117750983A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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CN202280047724.4A 2021-05-05 2022-05-05 用于使用硬纤毛蛋白双重载体系统治疗感觉神经性听力损失的组合物和方法 Pending CN117750983A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163184737P 2021-05-05 2021-05-05
US63/184737 2021-05-05
PCT/US2022/027870 WO2022235933A2 (en) 2021-05-05 2022-05-05 Compositions and methods for treating sensorineural hearing loss using stereocilin dual vector systems

Publications (1)

Publication Number Publication Date
CN117750983A true CN117750983A (zh) 2024-03-22

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CN202280047724.4A Pending CN117750983A (zh) 2021-05-05 2022-05-05 用于使用硬纤毛蛋白双重载体系统治疗感觉神经性听力损失的组合物和方法

Country Status (13)

Country Link
US (1) US20240216540A1 (https=)
EP (1) EP4333905A4 (https=)
JP (1) JP2024517843A (https=)
KR (1) KR20240021166A (https=)
CN (1) CN117750983A (https=)
AU (1) AU2022271265A1 (https=)
BR (1) BR112023022833A2 (https=)
CA (1) CA3219054A1 (https=)
CL (1) CL2023003260A1 (https=)
CO (1) CO2023016804A2 (https=)
IL (1) IL308142A (https=)
MX (1) MX2023013053A (https=)
WO (1) WO2022235933A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020014625A1 (en) 2018-07-13 2020-01-16 Akouos, Inc. Methods of treating non-syndromic sensorineural hearing loss
US20220054640A1 (en) * 2018-12-11 2022-02-24 Decibel Therapeutics, Inc. Compositions and methods for the delivery of therapeutic agents across the round window membrane
CN116925239B (zh) * 2023-07-17 2024-10-18 苏州星奥拓维生物技术有限公司 双载体系统表达Otof基因的组合物和方法
US20260027327A1 (en) 2024-07-26 2026-01-29 Regeneron Pharmaceuticals, Inc. Otic drug delivery system and methods

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008073303A2 (en) * 2006-12-07 2008-06-19 Switchgear Genomics Transcriptional regulatory elements of biological pathways, tools, and methods
WO2020014625A1 (en) * 2018-07-13 2020-01-16 Akouos, Inc. Methods of treating non-syndromic sensorineural hearing loss
WO2020077295A1 (en) * 2018-10-11 2020-04-16 Decibel Therapeutics, Inc. Aav1 vectors and uses thereof for treatment of otic indications
EP3880827A4 (en) * 2018-11-07 2023-04-26 Akouos, Inc. COMPOSITIONS AND METHODS FOR INDUCING DIFFERENTIATION OF A HAIR CELL
EP3921032A4 (en) * 2019-02-08 2022-11-30 Decibel Therapeutics, Inc. COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS

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Publication number Publication date
US20240216540A1 (en) 2024-07-04
KR20240021166A (ko) 2024-02-16
CA3219054A1 (en) 2022-11-10
MX2023013053A (es) 2024-01-12
AU2022271265A1 (en) 2023-12-14
BR112023022833A2 (pt) 2024-02-15
EP4333905A4 (en) 2025-03-26
WO2022235933A8 (en) 2023-02-02
WO2022235933A2 (en) 2022-11-10
EP4333905A2 (en) 2024-03-13
AU2022271265A9 (en) 2024-01-25
CO2023016804A2 (es) 2024-02-26
IL308142A (en) 2023-12-01
WO2022235933A3 (en) 2022-12-29
JP2024517843A (ja) 2024-04-23
CL2023003260A1 (es) 2024-05-31

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