JP2024516748A - ＥＧＦＲｖＩＩＩ結合タンパク質 - Google Patents

ＥＧＦＲｖＩＩＩ結合タンパク質 Download PDF

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JP2024516748A
JP2024516748A JP2024508815A JP2024508815A JP2024516748A JP 2024516748 A JP2024516748 A JP 2024516748A JP 2024508815 A JP2024508815 A JP 2024508815A JP 2024508815 A JP2024508815 A JP 2024508815A JP 2024516748 A JP2024516748 A JP 2024516748A
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amino acid
seq
egfrviii
binding protein
cells
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JP2024516748A5 (enExample
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ミスティ ジェンキンス
レベッカ アボット
ライアン クロス
フィオナ マーガレット グレイシー
レベッカ エリザベス ウッド
ベンジャミン ロス キーフェル
マシュー デイビッド ビースリー
Original Assignee
ザ ウォルター アンド イライザ ホール インスティテュート オブ メディカル リサーチ
マイリオ セラピューティクス プロプライエタリー リミテッド
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Priority claimed from AU2021901227A external-priority patent/AU2021901227A0/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/33—Antibodies; T-cell engagers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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JP2024508815A 2021-04-26 2022-04-26 ＥＧＦＲｖＩＩＩ結合タンパク質 Pending JP2024516748A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2021901227A AU2021901227A0 (en) 2021-04-26 EGFRvIII BINDING PROTEINS I
AU2021901227 2021-04-26
AU2021901226 2021-04-26
AU2021901226A AU2021901226A0 (en) 2021-04-26 EGFRvIII BINDING PROTEINS II
PCT/AU2022/050379 WO2022226584A1 (en) 2021-04-26 2022-04-26 EGFRvIII BINDING PROTEINS

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JP2024516748A true JP2024516748A (ja) 2024-04-16
JP2024516748A5 JP2024516748A5 (enExample) 2025-04-22

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US (1) US20240207407A1 (enExample)
EP (1) EP4330285A4 (enExample)
JP (1) JP2024516748A (enExample)
AU (1) AU2022267410A1 (enExample)
WO (1) WO2022226584A1 (enExample)

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Publication number Priority date Publication date Assignee Title
KR20240005794A (ko) * 2021-05-18 2024-01-12 쑤저우 카노바 바이오파마슈티컬 컴퍼니 리미티드 항 pd-1 폴리펩티드 및 그의 용도
WO2025080980A1 (en) * 2023-10-13 2025-04-17 The General Hospital Corporation Treating glioblastoma using car-t cell therapy

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2014130657A1 (en) * 2013-02-20 2014-08-28 The Trustees Of The University Of Pennsylvania Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor
WO2015143382A1 (en) * 2014-03-21 2015-09-24 Abbvie Inc. Anti-egfr antibodies and antibody drug conjugates
WO2020191485A1 (en) * 2019-03-27 2020-10-01 National Research Council Of Canada Anti-egfrviii antibodies and antigen-binding fragments thereof

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Publication number Priority date Publication date Assignee Title
RU2017102769A (ru) * 2014-07-29 2018-08-28 Пфайзер Инк. EGFRvIII СПЕЦИФИЧЕСКИЕ ХИМЕРНЫЕ АНТИГЕННЫЕ РЕЦЕПТОРЫ ДЛЯ ИММУНОТЕРАПИИ РАКА
EP3927371A1 (en) * 2019-02-22 2021-12-29 Novartis AG Combination therapies of egfrviii chimeric antigen receptors and pd-1 inhibitors

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2014130657A1 (en) * 2013-02-20 2014-08-28 The Trustees Of The University Of Pennsylvania Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor
WO2015143382A1 (en) * 2014-03-21 2015-09-24 Abbvie Inc. Anti-egfr antibodies and antibody drug conjugates
WO2020191485A1 (en) * 2019-03-27 2020-10-01 National Research Council Of Canada Anti-egfrviii antibodies and antigen-binding fragments thereof

Non-Patent Citations (2)

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