JP2024516633A - オレキシン－２受容体アゴニスト活性を有する置換されるアミド大環状化合物 - Google Patents

オレキシン－２受容体アゴニスト活性を有する置換されるアミド大環状化合物 Download PDF

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JP2024516633A
JP2024516633A JP2023565387A JP2023565387A JP2024516633A JP 2024516633 A JP2024516633 A JP 2024516633A JP 2023565387 A JP2023565387 A JP 2023565387A JP 2023565387 A JP2023565387 A JP 2023565387A JP 2024516633 A JP2024516633 A JP 2024516633A
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formula
another embodiment
alkylene
ring
alkyl
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JP2024516633A5 (enExample
Inventor
チェ，ヨンギ
フー，ユエン
ヒューン，ホアン
アクイラ，ブライアン，エム．
ライマー，ブライアン，ケネス
マッジ，インゴ，アンドレアス
ウッズ，ジェームズ，アール．
ペニントン，ルイス，ディー．
ベンツィエン，イョルグ，マーティン
レーマン，ジョナサン，ウォード
ヘール，マイケル，アール．
バリウリン，ローマン，エイ．
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アルカーメス，インコーポレイテッド
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Publication of JP2024516633A publication Critical patent/JP2024516633A/ja
Publication of JP2024516633A5 publication Critical patent/JP2024516633A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2023565387A 2021-04-26 2022-04-25 オレキシン－２受容体アゴニスト活性を有する置換されるアミド大環状化合物 Pending JP2024516633A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163179616P 2021-04-26 2021-04-26
US63/179,616 2021-04-26
PCT/US2022/026144 WO2022232025A1 (en) 2021-04-26 2022-04-25 Substituted amide macrocyclic compounds with orexin-2 receptor agonist activity

Publications (2)

Publication Number Publication Date
JP2024516633A true JP2024516633A (ja) 2024-04-16
JP2024516633A5 JP2024516633A5 (enExample) 2024-11-27

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JP2023565387A Pending JP2024516633A (ja) 2021-04-26 2022-04-25 オレキシン－２受容体アゴニスト活性を有する置換されるアミド大環状化合物

Country Status (8)

Country Link
US (1) US20240124485A1 (enExample)
EP (1) EP4329877B1 (enExample)
JP (1) JP2024516633A (enExample)
CN (1) CN117440955A (enExample)
AU (1) AU2022267220A1 (enExample)
CA (1) CA3215210A1 (enExample)
ES (1) ES3062687T3 (enExample)
WO (1) WO2022232025A1 (enExample)

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EP4622712A1 (en) * 2022-11-23 2025-10-01 Vertex Pharmaceuticals Incorporated Substituted macrocyclic amine modulators of orexin receptor 2
EP4658660A1 (en) 2023-01-31 2025-12-10 Jazz Pharmaceuticals Ireland Limited Macrocyclic orexin receptor agonists and uses thereof
KR20250155550A (ko) 2023-03-16 2025-10-30 다케다 야쿠힌 고교 가부시키가이샤 매크로시클릭 헤테로시클 화합물 및 이의 용도
US20240425521A1 (en) 2023-06-01 2024-12-26 H. Lundbeck A/S Spiromacrocyclic orexin 2 receptor agonists
WO2025096445A1 (en) 2023-10-30 2025-05-08 Alkermes, Inc. Synthesis of intermediates for the preparation of macrocyclic compounds
WO2025124698A1 (en) 2023-12-12 2025-06-19 Idorsia Pharmaceuticals Ltd Aryl sulfone and sulfanone derivatives as orexin receptor modulators
TW202542165A (zh) 2023-12-19 2025-11-01 瑞士商愛杜西亞製藥有限公司 大環食慾素激動劑
WO2026017128A1 (zh) * 2024-07-17 2026-01-22 江苏恩华药业股份有限公司 作为食欲素受体激动剂的环烯烃衍生物及其组合物和用途

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WO2018164191A1 (ja) * 2017-03-08 2018-09-13 武田薬品工業株式会社 置換ピロリジン化合物およびその用途
JP2019504098A (ja) * 2016-02-04 2019-02-14 武田薬品工業株式会社 置換ピペリジン化合物およびその用途
WO2020004536A1 (ja) * 2018-06-29 2020-01-02 武田薬品工業株式会社 複素環化合物およびその用途
WO2021026047A1 (en) * 2019-08-08 2021-02-11 Merck Sharp & Dohme Corp. Heteroaryl pyrrolidine and piperidine orexin receptor agonists

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MXPA01011018A (es) * 1999-04-30 2002-05-06 Pfizer Prod Inc Moduladores del receptor glucocorticoide.
EP2038255A2 (en) * 2006-06-16 2009-03-25 High Point Pharmaceuticals, LLC Pharmaceutical use of substituted piperidine carboxamides
US8258163B2 (en) 2008-06-04 2012-09-04 Board Of Regents, The University Of Texas System Small-molecule agonists for type-2 orexin receptor
MX2011004551A (es) * 2008-10-30 2011-05-25 Merck Sharp & Dohme Antagonistas del receptor de orexina de isonicotinamida.
KR20110096557A (ko) * 2008-12-10 2011-08-30 아칠리온 파르마세우티칼스 인코포레이티드 바이러스 복제의 억제제로서 4-아미노-4-옥소부타노일 펩티드 사이클릭 유사체
WO2014198880A1 (en) 2013-06-14 2014-12-18 Ferrer Internacional, S.A. 2-(2-aminophenoxy)-3-chloronaphthalene-1,4-dione compounds having orexin 2 receptor agonist activity
US20160250224A1 (en) 2013-09-24 2016-09-01 The Board Of Regents Of The University Of Texas System Orexin-control of bone formation and loss
CA2930693A1 (en) 2013-11-15 2015-05-21 The Board Of Trustees Of The Leland Stanford Junior Unversity Methods of treating heart failure with agonists of hypocretin receptor 2
PE20161064A1 (es) 2013-12-12 2016-10-28 Univ Tsukuba Derivado de sulfonamida o sales de adicion de acido farmaceuticamente aceptables del mismo
WO2015147240A1 (ja) 2014-03-28 2015-10-01 国立大学法人筑波大学 敗血症の予防治療剤
US20200207734A1 (en) 2017-08-03 2020-07-02 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
EA202192934A1 (ru) * 2017-12-25 2022-02-09 Такеда Фармасьютикал Компани Лимитед Гетероциклическое соединение и его применение
FI4065585T3 (fi) * 2019-11-25 2025-09-26 Alkermes Inc Substituoituja makrosyklisiä yhdisteitä ja niihin liittyviä hoitomenetelmiä
US12006330B2 (en) * 2020-12-21 2024-06-11 Alkermes, Inc. Substituted macrocyclic compounds and related methods of treatment

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Publication number Priority date Publication date Assignee Title
JP2019504098A (ja) * 2016-02-04 2019-02-14 武田薬品工業株式会社 置換ピペリジン化合物およびその用途
WO2018164191A1 (ja) * 2017-03-08 2018-09-13 武田薬品工業株式会社 置換ピロリジン化合物およびその用途
WO2020004536A1 (ja) * 2018-06-29 2020-01-02 武田薬品工業株式会社 複素環化合物およびその用途
WO2021026047A1 (en) * 2019-08-08 2021-02-11 Merck Sharp & Dohme Corp. Heteroaryl pyrrolidine and piperidine orexin receptor agonists

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Publication number Publication date
AU2022267220A1 (en) 2023-10-19
EP4329877A1 (en) 2024-03-06
US20240124485A1 (en) 2024-04-18
CA3215210A1 (en) 2022-11-03
ES3062687T3 (en) 2026-04-13
EP4329877B1 (en) 2026-02-04
CN117440955A (zh) 2024-01-23
EP4329877C0 (en) 2026-02-04
WO2022232025A1 (en) 2022-11-03

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