JP2024514880A - Ｐｎｐｌａ３発現を調節するための組成物及び方法 - Google Patents

Ｐｎｐｌａ３発現を調節するための組成物及び方法 Download PDF

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JP2024514880A
JP2024514880A JP2023562909A JP2023562909A JP2024514880A JP 2024514880 A JP2024514880 A JP 2024514880A JP 2023562909 A JP2023562909 A JP 2023562909A JP 2023562909 A JP2023562909 A JP 2023562909A JP 2024514880 A JP2024514880 A JP 2024514880A
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seq
strand
nos
dsirna
antisense
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JP2024514880A5 (https=
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ユトサフ サクセナ
ヘンリク ティー デュデック
マーク エイブラムス
アントン トゥラノフ
ボブ デール ブラウン
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Dicerna Pharmaceuticals Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2023562909A 2021-04-14 2022-04-13 Ｐｎｐｌａ３発現を調節するための組成物及び方法 Pending JP2024514880A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163174932P 2021-04-14 2021-04-14
US63/174,932 2021-04-14
PCT/US2022/024657 WO2022221430A1 (en) 2021-04-14 2022-04-13 Compositions and methods for modulating pnpla3 expression

Publications (2)

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JP2024514880A true JP2024514880A (ja) 2024-04-03
JP2024514880A5 JP2024514880A5 (https=) 2025-04-11

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US (2) US12084662B2 (https=)
EP (1) EP4323519A1 (https=)
JP (1) JP2024514880A (https=)
KR (1) KR20230171431A (https=)
CN (1) CN117120613A (https=)
AR (1) AR125351A1 (https=)
AU (1) AU2022258459A1 (https=)
BR (1) BR112023021109A2 (https=)
CA (1) CA3209418A1 (https=)
IL (1) IL307625A (https=)
MX (1) MX2023012216A (https=)
TW (2) TWI857290B (https=)
WO (1) WO2022221430A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3209418A1 (en) 2021-04-14 2022-10-20 Utsav SAXENA Compositions and methods for modulating pnpla3 expression
WO2024112865A1 (en) 2022-11-23 2024-05-30 Eli Lilly And Company Method of synthesizing 4'-phosphate analog nucleotide phosphoramidite
KR20250099265A (ko) 2022-11-23 2025-07-01 일라이 릴리 앤드 캄파니 표적화 리간드-접합된 뉴클레오티드 포스포르아미다이트의 합성 방법
WO2024182446A2 (en) * 2023-02-28 2024-09-06 Aligos Therapeutics, Inc. Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof

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US12084662B2 (en) 2024-09-10
EP4323519A1 (en) 2024-02-21
CA3209418A1 (en) 2022-10-20
US20220364098A1 (en) 2022-11-17
TW202500748A (zh) 2025-01-01
US20240401059A1 (en) 2024-12-05
TWI857290B (zh) 2024-10-01
KR20230171431A (ko) 2023-12-20
BR112023021109A2 (pt) 2023-12-12
CN117120613A (zh) 2023-11-24
TW202300645A (zh) 2023-01-01
IL307625A (en) 2023-12-01
WO2022221430A1 (en) 2022-10-20
AR125351A1 (es) 2023-07-12
MX2023012216A (es) 2023-10-26
AU2022258459A1 (en) 2023-09-14

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