JP2024514848A - ポルフィリン－ヒドロポルフィリン化合物、それを含む組成物、及びそれらの使用方法 - Google Patents

ポルフィリン－ヒドロポルフィリン化合物、それを含む組成物、及びそれらの使用方法 Download PDF

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Publication number
JP2024514848A
JP2024514848A JP2023562251A JP2023562251A JP2024514848A JP 2024514848 A JP2024514848 A JP 2024514848A JP 2023562251 A JP2023562251 A JP 2023562251A JP 2023562251 A JP2023562251 A JP 2023562251A JP 2024514848 A JP2024514848 A JP 2024514848A
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Japan
Prior art keywords
compound
group
hydroporphyrin
porphyrin
optionally
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JP2023562251A
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English (en)
Japanese (ja)
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JP2024514848A5 (https=
Inventor
エス． リンジー，ジョナサン
マクネビン，クリストファー
アキグベ，ジョシュア
ゴルチンスキー，ミハイル
雅彦 谷口
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North Carolina State University
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North Carolina State University
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Publication of JP2024514848A publication Critical patent/JP2024514848A/ja
Publication of JP2024514848A5 publication Critical patent/JP2024514848A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2023562251A 2021-04-07 2022-04-07 ポルフィリン－ヒドロポルフィリン化合物、それを含む組成物、及びそれらの使用方法 Pending JP2024514848A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163171870P 2021-04-07 2021-04-07
US63/171,870 2021-04-07
PCT/US2022/023827 WO2022216927A1 (en) 2021-04-07 2022-04-07 Porphyrin-hydroporphyrin compounds, compositions comprising the same and methods of use thereof

Publications (2)

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JP2024514848A true JP2024514848A (ja) 2024-04-03
JP2024514848A5 JP2024514848A5 (https=) 2025-04-09

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JP2023562251A Pending JP2024514848A (ja) 2021-04-07 2022-04-07 ポルフィリン－ヒドロポルフィリン化合物、それを含む組成物、及びそれらの使用方法

Country Status (6)

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US (1) US20250295815A1 (https=)
EP (1) EP4319823A4 (https=)
JP (1) JP2024514848A (https=)
CN (1) CN117881432A (https=)
CA (1) CA3213957A1 (https=)
WO (1) WO2022216927A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116519116B (zh) * 2023-03-30 2024-06-21 苏州大学 一种掺杂型锌铜压电声敏剂及其制备方法与应用
CN119101058B (zh) * 2024-09-03 2025-09-12 徐州医科大学 一种用于生物成像与声动力治疗的卟啉化合物及其制备方法与应用

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US6420648B1 (en) * 2000-07-21 2002-07-16 North Carolina State University Light harvesting arrays
US20100016208A1 (en) * 2005-11-15 2010-01-21 The General Hospital Corporation Photoactivatable antimicrobial agents
ES2707228T3 (es) * 2008-09-18 2019-04-03 Biolitec Unternehmensbeteiligungs Ii Ag Nuevo método y aplicación de porfirinas y clorinas asimétricamente meso-sustituidas para TFD
US20110275686A1 (en) * 2009-12-11 2011-11-10 Biolitec, Inc. Nanoparticle carrier systems based on poly(dl-lactic-co-glycolic acid) (plga) for photodynamic therapy (pdt)
CN105396135B (zh) * 2015-12-15 2019-03-15 青龙高科技股份有限公司 靶向性多肽修饰的铁蛋白纳米颗粒装载卟啉二聚体盐复合物及其用途和制备方法
WO2017214637A1 (en) * 2016-06-10 2017-12-14 Nirvana Sciences Inc. Hydroporphyrin beads with narrow fluorescence emissions

Non-Patent Citations (22)

* Cited by examiner, † Cited by third party
Title
"Simultaneous Implementation of N-Heterocycle-Fused Bridge and Modified Pyrrole Unit on Ni(II) Porphy", ORGANIC LETTERS, vol. 22(15), JPN7026000396, 2020, pages 6001 - 6005, ISSN: 0005791477 *
BYRNE, CHRISTOPHER J. ET AL.: "The Photodynamic Therapy (PDT) Anticancer Activity of a Range of Porphyrin Dimers and Related Compou", AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 57(11), JPN7026000398, 2004, pages 1091 - 1102, ISSN: 0005791479 *
DOMINGUES, M. ROSARIO M. ET AL.: "Liquid secondary ion mass spectrometry of porphyrin dimers: reduction reactions and structural chara", RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 14(21), JPN7026000395, 2000, pages 2025 - 2029, ISSN: 0005791476 *
GUNTER, MAXWELL J. ET AL.: "Porphodimethylidenes from porphyrin-fused 3-sulfolenes-versatile porphyrin dienes for cycloadditions", CHEMICAL COMMUNICATIONS, vol. 9, JPN7026000397, 1999, pages 803 - 804, ISSN: 0005791478 *
JAQUINOD, LAURENT ET AL.: "Synthesis and characterization of bis(chlorin)s from the McMurry reaction of formylchlorins", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION IN ENGLISH, vol. 35(9), JPN7026000392, 1996, pages 1013 - 1016, ISSN: 0005791473 *
KAI, XIAOXU ET AL.: "Facile one-pot synthesis of unprecedented β,β'-linked porphyrin-chlorin heterodimers", CHEMICAL COMMUNICATIONS, vol. 48(36), JPN7026000400, 2012, pages 4302 - 4304, ISSN: 0005791481 *
KALISCH, WERNER W. ET AL.: "Synthesis and crystal structures of cofacial bisoctaethylchlorins as structural models for the speci", PHOTOCHEMISTRY AND PHOTOBIOLOGY, vol. 67(3), JPN7026000390, 1998, pages 312 - 323, ISSN: 0005791471 *
KESSEL, DAVID ET AL.: "Photosensitization by synthetic diporphyrins and dichlorins in vivo and in vitro", PHOTOCHEMISTRY AND PHOTOBIOLOGY, vol. 53(4), JPN7026000383, 1991, pages 475 - 9, ISSN: 0005791464 *
KNYUKSHTO, V. N. ET AL.: "Interchromophore interactions and energy transfer in covalently bound porphyrin-chlorin heterodimer", JOURNAL OF APPLIED SPECTROSCOPY (TRANSLATION OF ZHURNAL PRIKLADNOI SPEKTROSKOPII), vol. 65(1, JPN7026000387, 1998, pages 75 - 83, ISSN: 0005791468 *
KOZYREV, ANDREI N. ET AL.: "Thermolysis of vic-Dihydroxybacteriochlorins: A New Approach for the Synthesis of Chlorin-Chlorin an", ORGANIC LETTERS, vol. 1(8), JPN7026000403, 1999, pages 1193 - 1196, ISSN: 0005791484 *
MARIA A. F. FAUSTINO ET AL.: "Phototherapeutic properties of meso-tetraphenylporphyrin dimer derivatives: a comparative study", INTERNET PHOTOCHEMISTRY & PHOTOBIOLOGY [ONLINE COMPUTER FILE], vol. 3rd, JPN7026000384, 2000, ISSN: 0005791465 *
MELISSARI, ZOI ET AL.: "Synthesis and spectral properties of gem-dimethyl chlorin photosensitizers", CHEMRXIV (2020) 1-12, 2020, vol. 2020, JPN7026000385, 2020, pages 1 - 12, ISSN: 0005791466 *
MIRONOV, A. F. ET AL.: "Peculiarities of photoinduced singlet oxygen generation in the presence of porphyrin-chlorin dimers", ZHURNAL FIZICHESKOI KHIMII, vol. 73(2), JPN7026000388, 1999, pages 253 - 255, ISSN: 0005791469 *
OSUKA, ATSUHIRO ET AL.: "A chemical approach towards the photosynthetic reaction center", PURE AND APPLIED CHEMISTRY, vol. 69(4), JPN7026000394, 1997, pages 797 - 802, ISSN: 0005791475 *
OSUKA, ATSUHIRO ET AL.: "A Stepwise Electron-Transfer Relay Mimicking the Primary Charge Separation in Bacterial Photosynthet", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 118(1), JPN7026000393, 1996, pages 155 - 68, ISSN: 0005791474 *
PAOLESSE, ROBERTO ET AL.: "Stepwise Syntheses of Bisporphyrins, Bischlorins, and Biscorroles, and of Porphyrin-Chlorin and Porp", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 118(16), JPN7026000391, 1996, pages 3869 - 82, ISSN: 0005791472 *
TAMIAKI, HITOSHI ET AL.: "Intramolecular interaction of synthetic chlorophyll heterodyads with different π-skeletons", PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, vol. 19(3), JPN7026000401, 2020, pages 332 - 340, ISSN: 0005791482 *
WASIELEWSKI, MICHAEL R. ET AL.: "Chlorin-based supramolecular assemblies for artificial photosynthesis", SOLAR ENERGY MATERIALS AND SOLAR CELLS, vol. 38(1-4), JPN7026000404, 1995, pages 127 - 34, ISSN: 0005791485 *
YASHUNSKY, D. V. ET AL.: "Porphyrins. 37. Synthesis of heterodimers of porphyrins and chlorins containing pyrrolylmethyl bridg", CHEMISTRY OF HETEROCYCLIC COMPOUNDS(TRANSLATION OF KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII), vol. 36(3), JPN7026000389, 2000, pages 275 - 280, ISSN: 0005791470 *
ZENKEVICH, E. I. ET AL.: "Spectroscopic and photophysical properties of covalent ether-bonded porphyrin-chlorin heterodimers", JOURNAL OF LUMINESCENCE, vol. 75(3), JPN7026000386, 1997, pages 229 - 244, ISSN: 0005791467 *
ZHENG, GANG ET AL.: "Syntheses and spectroscopic studies of some novel porphyrin-pyropheophorbide dimers and trimers with", TETRAHEDRON LETTERS, vol. 38(14), JPN7026000399, 1997, pages 2409 - 2412, ISSN: 0005791480 *
ZHUO, CONGCONG ET AL.: "Synthesis and characterization of β,β'-linked porphyrin-chlorin heterodimers and their metallic co", JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, vol. 21(3), JPN7026000402, 2017, pages 211 - 221, ISSN: 0005791483 *

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EP4319823A4 (en) 2025-04-23
CA3213957A1 (en) 2022-10-13
CN117881432A (zh) 2024-04-12
WO2022216927A9 (en) 2023-09-14
WO2022216927A1 (en) 2022-10-13
EP4319823A1 (en) 2024-02-14
US20250295815A1 (en) 2025-09-25

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