JP2024514844A5 - - Google Patents
Info
- Publication number
- JP2024514844A5 JP2024514844A5 JP2023561783A JP2023561783A JP2024514844A5 JP 2024514844 A5 JP2024514844 A5 JP 2024514844A5 JP 2023561783 A JP2023561783 A JP 2023561783A JP 2023561783 A JP2023561783 A JP 2023561783A JP 2024514844 A5 JP2024514844 A5 JP 2024514844A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- inhibitor
- alkyl
- pharmaceutical composition
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163171955P | 2021-04-07 | 2021-04-07 | |
| US63/171,955 | 2021-04-07 | ||
| PCT/CA2022/050536 WO2022213204A1 (en) | 2021-04-07 | 2022-04-07 | Combination therapies including myt1 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024514844A JP2024514844A (ja) | 2024-04-03 |
| JP2024514844A5 true JP2024514844A5 (enExample) | 2025-04-03 |
Family
ID=83544890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023561783A Pending JP2024514844A (ja) | 2021-04-07 | 2022-04-07 | Ｍｙｔ１阻害剤を含む併用治療 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240207300A1 (enExample) |
| EP (1) | EP4319752A4 (enExample) |
| JP (1) | JP2024514844A (enExample) |
| CN (1) | CN117729920A (enExample) |
| CA (1) | CA3214900A1 (enExample) |
| WO (1) | WO2022213204A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220035925A (ko) | 2019-07-22 | 2022-03-22 | 리페어 세라퓨틱스 인크. | Atr 키나제 억제제로서의 치환된 2-모르폴리노피리딘 유도체 |
| US12435090B2 (en) | 2021-10-04 | 2025-10-07 | Repare Therapeutics Inc. | Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use |
| EP4556474A1 (en) * | 2022-07-12 | 2025-05-21 | Wigen Biomedicine Technology (Shanghai) Co., Ltd. | Compounds as myt1 inhibitors |
| TW202434253A (zh) * | 2022-11-08 | 2024-09-01 | 美商薩諾管理公司 | 週期蛋白ｅ１狀態作為預測性生物標記用於用ｗｅｅ１抑制劑治療癌症之用途 |
| WO2024104282A1 (zh) * | 2022-11-14 | 2024-05-23 | 捷思英达控股有限公司 | 一种1H-吡咯并[2,3-b]吡啶衍生物、其制备方法及其在医药上的应用 |
| JP2025538617A (ja) * | 2022-11-25 | 2025-11-28 | 上海齊魯制藥研究中心有限公司 | Ｐｋｍｙｔ１阻害剤、製造方法、医薬組成物及びその使用 |
| EP4638449A1 (en) * | 2022-12-22 | 2025-10-29 | Repare Therapeutics Inc. | Methods of making 2-amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6- dimethyl-1h-pyrrolo-[2,3-b]pyridine-3-carboxamide, a myt1 inhibitor |
| CN120641415A (zh) * | 2023-01-20 | 2025-09-12 | 杭州英创医药科技有限公司 | 作为pkmyt1抑制剂的化合物 |
| EP4658293A1 (en) * | 2023-01-30 | 2025-12-10 | Ecole Polytechnique Federale De Lausanne (Epfl) | Pou5f1b inhibitors |
| WO2024179948A1 (en) * | 2023-02-28 | 2024-09-06 | F. Hoffmann-La Roche Ag | Indazole compounds as pkmyt1 kinase inhibitors |
| AU2024231943A1 (en) * | 2023-03-09 | 2025-10-16 | Cancer Research Technology Limited | Biarylamide derivatives and their use as pkmyt1 inhibitors |
| CN121175306A (zh) * | 2023-05-12 | 2025-12-19 | 智擎生技制药股份有限公司 | 稠合吡咯环或稠合吡啶环的化合物 |
| CN121358735A (zh) * | 2023-07-04 | 2026-01-16 | 杭州领业医药科技有限公司 | Rp-6306的晶型及其制备方法和用途 |
| WO2025040014A1 (zh) * | 2023-08-18 | 2025-02-27 | 英矽智能科技知识产权有限公司 | 并环化合物及其制备方法和用途 |
| EP4777102A1 (en) * | 2023-09-14 | 2026-07-22 | Debiopharm International SA | Combination of a wee1 inhibitor and a pkmyt1 inhibitor |
| WO2025060975A1 (en) * | 2023-09-18 | 2025-03-27 | Insilico Medicine Ip Limited | Novel compounds as pkmyt1 inhibitors and use thereof |
| IL327457A (en) * | 2023-10-02 | 2026-05-01 | Repare Therapeutics Inc | MYT1 inhibitors for the treatment of cancers containing mutations resulting from replication checkpoints |
| AU2024356662A1 (en) * | 2023-10-02 | 2026-04-30 | Repare Therapeutics, Inc. | Combination therapies including myt1 inhibitors and wee1 inhibitors |
| WO2025106635A1 (en) * | 2023-11-15 | 2025-05-22 | Zeno Management, Inc. | Alteration of f-box and wd repeat domain containing 7 (fbxw7) gene as a predictive biomarker for treating cancer with wee1 inhibitors |
| WO2025121807A1 (ko) * | 2023-12-08 | 2025-06-12 | 인제대학교 산학협력단 | Ezh2 저해제 및 mettl3 억제제를 포함하는 암의 예방 또는 치료용 약제학적 조성물 |
| JPWO2025182927A1 (enExample) * | 2024-02-27 | 2025-09-04 | ||
| WO2025188680A1 (en) * | 2024-03-04 | 2025-09-12 | Cardiff Oncology, Inc. | Use of plk1 inhibitor in combination of gemcitabine or carboplatin in treating ovarian carcinoma |
| WO2025237957A1 (en) * | 2024-05-14 | 2025-11-20 | Institut Curie | Composition for treatment of estrogen-dependent cancer comprising a mettl-3 inhibitor and a topoisomerase-1 inhibitor |
| EP4686475A1 (en) | 2024-07-31 | 2026-02-04 | Fundação D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud - Centro De Investigação Da Fundação Champalimaud | Xpg inhibitors for use in the treatment of cancer |
| WO2026125935A1 (en) * | 2024-12-09 | 2026-06-18 | Repare Therapeutics Inc. | Methods of treating cancers having fbxw7 mutations |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000033837A2 (en) * | 1998-12-07 | 2000-06-15 | Smithkline Beecham Corporation | Myt1 kinase inhibitors |
| WO2016104777A1 (ja) * | 2014-12-26 | 2016-06-30 | 国立大学法人九州大学 | がんの処置のための方法 |
| CN115811976A (zh) * | 2020-04-01 | 2023-03-17 | 修复治疗公司 | 使用myt1抑制剂的方法 |
| ES3067113T3 (en) * | 2020-04-01 | 2026-05-19 | Repare Therapeutics Inc | N-phenyl substituted indole derivatives as myt1 inhibitors for the treatment of cancer |
-
2022
- 2022-04-07 US US18/284,614 patent/US20240207300A1/en active Pending
- 2022-04-07 JP JP2023561783A patent/JP2024514844A/ja active Pending
- 2022-04-07 EP EP22783740.8A patent/EP4319752A4/en active Pending
- 2022-04-07 CN CN202280040614.5A patent/CN117729920A/zh active Pending
- 2022-04-07 WO PCT/CA2022/050536 patent/WO2022213204A1/en not_active Ceased
- 2022-04-07 CA CA3214900A patent/CA3214900A1/en active Pending
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