JP2024513313A - CD66eポリペプチドに結合する分子 - Google Patents
CD66eポリペプチドに結合する分子 Download PDFInfo
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- JP2024513313A JP2024513313A JP2023554307A JP2023554307A JP2024513313A JP 2024513313 A JP2024513313 A JP 2024513313A JP 2023554307 A JP2023554307 A JP 2023554307A JP 2023554307 A JP2023554307 A JP 2023554307A JP 2024513313 A JP2024513313 A JP 2024513313A
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- Prior art keywords
- seq
- antigen
- amino acid
- binding
- cd66e
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
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- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/31—Chimeric antigen receptors [CAR]
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- A—HUMAN NECESSITIES
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/3007—Carcino-embryonic Antigens
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/622—Single chain antibody (scFv)
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- Immunology (AREA)
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- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Medicinal Chemistry (AREA)
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- Veterinary Medicine (AREA)
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- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163158205P | 2021-03-08 | 2021-03-08 | |
| US63/158,205 | 2021-03-08 | ||
| PCT/US2022/019375 WO2022192281A1 (en) | 2021-03-08 | 2022-03-08 | MOLECULES THAT BIND TO CD66e POLYPEPTIDES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024513313A true JP2024513313A (ja) | 2024-03-25 |
| JP2024513313A5 JP2024513313A5 (https=) | 2025-02-05 |
Family
ID=83228255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023554307A Pending JP2024513313A (ja) | 2021-03-08 | 2022-03-08 | CD66eポリペプチドに結合する分子 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240166760A1 (https=) |
| EP (1) | EP4305069A4 (https=) |
| JP (1) | JP2024513313A (https=) |
| AU (1) | AU2022233150A1 (https=) |
| CA (1) | CA3212830A1 (https=) |
| WO (1) | WO2022192281A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4608874A2 (en) * | 2022-10-28 | 2025-09-03 | Memorial Sloan Kettering Cancer Center | Anti-adam10 antibodies and uses in treatment of cancer |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016506370A (ja) * | 2012-11-20 | 2016-03-03 | サノフイ | 抗ceacam5抗体およびその使用 |
| WO2019204827A2 (en) * | 2018-04-20 | 2019-10-24 | The Regents Of The University Of California | Treatment of prostate cancer using chimeric antigen receptors |
| WO2020244526A1 (zh) * | 2019-06-04 | 2020-12-10 | 上海吉倍生物技术有限公司 | 一种抗ceacam5的单克隆抗体及其制备方法和用途 |
| WO2020247392A1 (en) * | 2019-06-04 | 2020-12-10 | Nkarta, Inc. | Combinations of engineered natural killer cells and engineered t cells for immunotherapy |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ME00502B (me) * | 2001-01-05 | 2011-10-10 | Amgen Fremont Inc | Antitjela za insulinu sličan receptor faktora i rasta |
| WO2004050850A2 (en) * | 2002-12-02 | 2004-06-17 | Abgenix, Inc. | Antibodies directed to phospholipase a2 and uses thereof |
| EP2478110B1 (en) * | 2009-09-16 | 2016-01-06 | Immunomedics, Inc. | Class i anti-cea antibodies and uses thereof |
-
2022
- 2022-03-08 US US18/281,157 patent/US20240166760A1/en active Pending
- 2022-03-08 JP JP2023554307A patent/JP2024513313A/ja active Pending
- 2022-03-08 EP EP22767820.8A patent/EP4305069A4/en active Pending
- 2022-03-08 AU AU2022233150A patent/AU2022233150A1/en active Pending
- 2022-03-08 CA CA3212830A patent/CA3212830A1/en active Pending
- 2022-03-08 WO PCT/US2022/019375 patent/WO2022192281A1/en not_active Ceased
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016506370A (ja) * | 2012-11-20 | 2016-03-03 | サノフイ | 抗ceacam5抗体およびその使用 |
| WO2019204827A2 (en) * | 2018-04-20 | 2019-10-24 | The Regents Of The University Of California | Treatment of prostate cancer using chimeric antigen receptors |
| WO2020244526A1 (zh) * | 2019-06-04 | 2020-12-10 | 上海吉倍生物技术有限公司 | 一种抗ceacam5的单克隆抗体及其制备方法和用途 |
| WO2020247392A1 (en) * | 2019-06-04 | 2020-12-10 | Nkarta, Inc. | Combinations of engineered natural killer cells and engineered t cells for immunotherapy |
Non-Patent Citations (2)
| Title |
|---|
| BRITISH JOURNAL OF CANCER, vol. 102, JPN6025052942, 2010, pages 124 - 133, ISSN: 0005765906 * |
| PNAS, vol. 115, no. 19, JPN6025052941, 2018, pages 4473 - 4482, ISSN: 0005765905 * |
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| EP4305069A4 (en) | 2025-01-01 |
| US20240166760A1 (en) | 2024-05-23 |
| WO2022192281A1 (en) | 2022-09-15 |
| EP4305069A1 (en) | 2024-01-17 |
| AU2022233150A1 (en) | 2023-09-21 |
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