JP2024513238A - 抗ror1/抗cd3二重特異性抗体を発現する腫瘍溶解性ウイルス - Google Patents

抗ror1/抗cd3二重特異性抗体を発現する腫瘍溶解性ウイルス Download PDF

Info

Publication number
JP2024513238A
JP2024513238A JP2023561292A JP2023561292A JP2024513238A JP 2024513238 A JP2024513238 A JP 2024513238A JP 2023561292 A JP2023561292 A JP 2023561292A JP 2023561292 A JP2023561292 A JP 2023561292A JP 2024513238 A JP2024513238 A JP 2024513238A
Authority
JP
Japan
Prior art keywords
cells
hsv
ror1
seq
sepgi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023561292A
Other languages
English (en)
Japanese (ja)
Inventor
ダミアン ブレッソン,
コリン パワーズ,
ロバート アレン,
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sorrento Therapeutics Inc
Original Assignee
Sorrento Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sorrento Therapeutics Inc filed Critical Sorrento Therapeutics Inc
Publication of JP2024513238A publication Critical patent/JP2024513238A/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • A61K35/763Herpes virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16632Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16651Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2023561292A 2021-04-09 2022-04-08 抗ror1/抗cd3二重特異性抗体を発現する腫瘍溶解性ウイルス Pending JP2024513238A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163173205P 2021-04-09 2021-04-09
US63/173,205 2021-04-09
PCT/US2022/024017 WO2022217048A1 (fr) 2021-04-09 2022-04-08 Virus oncolytiques exprimant des anticorps bispécifiques anti-ror1/anti-cd3

Publications (1)

Publication Number Publication Date
JP2024513238A true JP2024513238A (ja) 2024-03-22

Family

ID=83545781

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023561292A Pending JP2024513238A (ja) 2021-04-09 2022-04-08 抗ror1/抗cd3二重特異性抗体を発現する腫瘍溶解性ウイルス

Country Status (6)

Country Link
EP (1) EP4320243A1 (fr)
JP (1) JP2024513238A (fr)
CN (1) CN117460833A (fr)
CA (1) CA3214641A1 (fr)
TW (1) TW202305000A (fr)
WO (1) WO2022217048A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2789630A1 (fr) * 2013-04-09 2014-10-15 EngMab AG Anticorps bispécifiques contre le CD3e et ROR1
JP2022533702A (ja) * 2019-05-20 2022-07-25 パンディオン・オペレーションズ・インコーポレイテッド MAdCAM標的化免疫寛容
WO2021003189A1 (fr) * 2019-07-01 2021-01-07 Sorrento Therapeutics, Inc. Anticorps hétérodimères se liant à cd38 et cd3

Also Published As

Publication number Publication date
EP4320243A1 (fr) 2024-02-14
CA3214641A1 (fr) 2022-10-13
CN117460833A (zh) 2024-01-26
WO2022217048A1 (fr) 2022-10-13
TW202305000A (zh) 2023-02-01

Similar Documents

Publication Publication Date Title
ES2914177T3 (es) Anticuerpos anti-OX40 humanizados y usos de los mismos
WO2020238730A1 (fr) Nouvelle molécule de liaison cldn18.2
EP4019550A1 (fr) Anticorps anti-pd-l1 à domaine unique
CN115710311A (zh) 冠状病毒的抗体或其抗原结合片段
KR102323960B1 (ko) 항-pd-l1 항체 및 이의 용도
TWI829677B (zh) 新型抗pd-1抗體
WO2022037531A1 (fr) Anticorps anti-cd73 et son utilisation
TW201522373A (zh) 抗cd52之抗體
CN114524877A (zh) 结合cd38的经工程改造的变异抗体
US20230331846A1 (en) Canine PD-1-Binding Polypeptides and Uses Thereof
JP7445752B2 (ja) 新規の抗pd-l1抗体
US20230357793A1 (en) Oncolytic herpes simplex viruses (hsv) expressing immunomodulatory fusion proteins
JP2024513238A (ja) 抗ror1/抗cd3二重特異性抗体を発現する腫瘍溶解性ウイルス
EP4279509A1 (fr) Anticorps de protéine garp et son application
US20240209081A1 (en) Anti-cntn4-specific antibodies and use thereof
US20180179274A1 (en) Proteins comprising a mutated lair-1 fragment and uses thereof
KR20220117267A (ko) Tgf-베타-rii 결합 단백질
US20240218074A1 (en) Anti-cd73 antibody and use thereof
CN118176016A (zh) 抗体的新型组合及其用途
CA3231396A1 (fr) Nouvelles combinaisons d'anticorps et utilisations associees
WO2024133330A1 (fr) DOMAINES DE LIAISON FAP ET FRACTIONS DE LIAISON BISPÉCIFIQUES QUI SE LIENT À FAP ET TGF-βRII
BR122023027661A2 (pt) Proteínas de ligação de tgf-beta-rii
KR20230160307A (ko) 클라우딘-3을 표적화하는 키메라 항원 수용체 및 암을 치료하는 방법
CN118047869A (zh) 抗pd-l1抗体及其用途