JP2024510900A - Ａｐ－１転写因子をコードするコドン最適化ヌクレオチド配列 - Google Patents

Ａｐ－１転写因子をコードするコドン最適化ヌクレオチド配列 Download PDF

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JP2024510900A
JP2024510900A JP2023551754A JP2023551754A JP2024510900A JP 2024510900 A JP2024510900 A JP 2024510900A JP 2023551754 A JP2023551754 A JP 2023551754A JP 2023551754 A JP2023551754 A JP 2023551754A JP 2024510900 A JP2024510900 A JP 2024510900A
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polynucleotide
cell
seq
nucleotide sequence
vector
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JP2024510900A5 (https=
Inventor
パーク，スペンサー
ボン，クイニー
セイザー，ブライス
リュ，ビョン
ラジョワ，マーク
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Lyell Immunopharma Inc
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Lyell Immunopharma Inc
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C07K2319/00—Fusion polypeptide
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2023551754A 2021-02-25 2022-02-24 Ａｐ－１転写因子をコードするコドン最適化ヌクレオチド配列 Pending JP2024510900A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163153879P 2021-02-25 2021-02-25
US63/153,879 2021-02-25
US202163263231P 2021-10-28 2021-10-28
US63/263,231 2021-10-28
US202263309380P 2022-02-11 2022-02-11
US63/309,380 2022-02-11
PCT/US2022/017733 WO2022182890A1 (en) 2021-02-25 2022-02-24 Codon-optimized nucleotide sequences encoding an ap-1 transcription factor

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JP2024510900A true JP2024510900A (ja) 2024-03-12
JP2024510900A5 JP2024510900A5 (https=) 2025-03-19

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US (2) US12270032B2 (https=)
EP (1) EP4298230A1 (https=)
JP (1) JP2024510900A (https=)
KR (1) KR20230150834A (https=)
AU (1) AU2022226655A1 (https=)
CA (1) CA3174248A1 (https=)
WO (1) WO2022182890A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021189008A1 (en) 2020-03-20 2021-09-23 Lyell Immunopharma, Inc. Novel recombinant cell surface markers
US12144827B2 (en) 2021-02-25 2024-11-19 Lyell Immunopharma, Inc. ROR1 targeting chimeric antigen receptor
EP4298230A1 (en) 2021-02-25 2024-01-03 Lyell Immunopharma, Inc. Codon-optimized nucleotide sequences encoding an ap-1 transcription factor
WO2025089255A1 (ja) * 2023-10-23 2025-05-01 慶應義塾 長期生存型ｔ細胞、医薬組成物、及び使用方法
WO2025131119A1 (en) * 2023-12-22 2025-06-26 Everest Medicines (China) Co., Ltd. Cancer vaccines and uses thereof
WO2025184170A1 (en) * 2024-02-27 2025-09-04 Overt Bio, Inc. Methods and compositions for improving t cell function in an immunosuppressive environment
WO2025199252A1 (en) * 2024-03-19 2025-09-25 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Inducible transcription factor expression for modulating immune cell function

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JP2015518816A (ja) * 2012-04-02 2015-07-06 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2018517674A (ja) * 2015-04-22 2018-07-05 キュアバック アーゲー 癌疾患の処置のための、ｒｎａ含有組成物
WO2019118902A2 (en) * 2017-12-15 2019-06-20 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for inhibiting t cell exhaustion
WO2021142376A1 (en) * 2020-01-08 2021-07-15 Obsidian Therapeutics, Inc. Compositions and methods for tunable regulation of transcription

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CN101851668A (zh) 2009-08-10 2010-10-06 芮屈生物技术（上海）有限公司 一种ap-1基因的原位杂交检测试剂盒及其检测方法和应用
TR201904484T4 (tr) 2009-11-03 2019-05-21 Hope City Transdüse T hücre seçimine yönelik kesik epiderimal büyüme faktörü reseptörü (EGFRt).
GB201515351D0 (en) 2015-08-28 2015-10-14 Cancer Res Technology Antibody
CN106636210B (zh) 2016-10-09 2019-07-19 广州暨南大学医药生物技术研究开发中心 转录因子组合诱导成纤维细胞转分化为类睾丸间质细胞的方法
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JP7538601B2 (ja) 2017-04-26 2024-08-22 ユーリカ セラピューティックス， インコーポレイテッド キメラ活性化受容体及びキメラ刺激受容体を発現する細胞並びにその使用
US20210299223A1 (en) 2018-07-31 2021-09-30 Washington University Use of interleukin-7 and chimeric antigen receptor (car)-bearing immune effector cells for treating tumor
SG11202111865UA (en) 2019-05-01 2021-11-29 Pact Pharma Inc Compositions and methods for the treatment of cancer using a tet2 engineered t cell therapy
EP4298230A1 (en) 2021-02-25 2024-01-03 Lyell Immunopharma, Inc. Codon-optimized nucleotide sequences encoding an ap-1 transcription factor
US12144827B2 (en) 2021-02-25 2024-11-19 Lyell Immunopharma, Inc. ROR1 targeting chimeric antigen receptor

Patent Citations (4)

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JP2015518816A (ja) * 2012-04-02 2015-07-06 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2018517674A (ja) * 2015-04-22 2018-07-05 キュアバック アーゲー 癌疾患の処置のための、ｒｎａ含有組成物
WO2019118902A2 (en) * 2017-12-15 2019-06-20 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for inhibiting t cell exhaustion
WO2021142376A1 (en) * 2020-01-08 2021-07-15 Obsidian Therapeutics, Inc. Compositions and methods for tunable regulation of transcription

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US20220307039A1 (en) 2022-09-29
US12270032B2 (en) 2025-04-08
EP4298230A1 (en) 2024-01-03
CA3174248A1 (en) 2022-09-01
AU2022226655A9 (en) 2025-01-30
AU2022226655A1 (en) 2023-07-27
US20250297268A1 (en) 2025-09-25
WO2022182890A1 (en) 2022-09-01
KR20230150834A (ko) 2023-10-31

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