JP2024505595A - Ｔｒｐｍ８アクチベーターとしての有機化合物 - Google Patents
Ｔｒｐｍ８アクチベーターとしての有機化合物 Download PDFInfo
- Publication number
- JP2024505595A JP2024505595A JP2023547811A JP2023547811A JP2024505595A JP 2024505595 A JP2024505595 A JP 2024505595A JP 2023547811 A JP2023547811 A JP 2023547811A JP 2023547811 A JP2023547811 A JP 2023547811A JP 2024505595 A JP2024505595 A JP 2024505595A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- formula
- imidazol
- tolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/24—Thermal properties
- A61K2800/244—Endothermic; Cooling; Cooling sensation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Confectionery (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Non-Alcoholic Beverages (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2021/076366 | 2021-02-09 | ||
| PCT/CN2021/076366 WO2022170519A1 (en) | 2021-02-09 | 2021-02-09 | Organic compounds |
| PCT/EP2022/053085 WO2022171653A1 (en) | 2021-02-09 | 2022-02-09 | Organic compounds as trpm8 activators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024505595A true JP2024505595A (ja) | 2024-02-06 |
| JPWO2022171653A5 JPWO2022171653A5 (https=) | 2025-02-06 |
| JP2024505595A5 JP2024505595A5 (https=) | 2025-02-06 |
Family
ID=80447119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023547811A Pending JP2024505595A (ja) | 2021-02-09 | 2022-02-09 | Ｔｒｐｍ８アクチベーターとしての有機化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240139087A1 (https=) |
| EP (1) | EP4291553A1 (https=) |
| JP (1) | JP2024505595A (https=) |
| CN (1) | CN116867775A (https=) |
| MX (1) | MX2023008005A (https=) |
| WO (2) | WO2022170519A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4583718A1 (en) | 2022-10-27 | 2025-07-16 | Firmenich SA | Flavonoid compositions and uses thereof |
| WO2024132554A1 (en) | 2022-12-22 | 2024-06-27 | Firmenich Sa | Natural sweetener compositions and uses thereof |
| WO2024132552A1 (en) | 2022-12-22 | 2024-06-27 | Firmenich Sa | Natural sweetener compositions containing alkyl lactates and uses thereof |
| JP2026511252A (ja) | 2023-03-28 | 2026-04-10 | フイルメニツヒ ソシエテ アノニム | 味改変組成物およびその使用 |
| WO2025202256A1 (en) * | 2024-03-28 | 2025-10-02 | Firmenich Sa | Cooling composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016172769A (ja) * | 2010-11-05 | 2016-09-29 | セノミックス インコーポレイテッド | Ｔｒｐｍ８の活性調節因子として有用な化合物 |
| JP2018535937A (ja) * | 2015-10-01 | 2018-12-06 | セノミックス インコーポレイテッドＳｅｎｏｍｙｘ， Ｉｎｃ． | Ｔｒｐｍ８の活性調節因子として有用な化合物 |
| JP2020526632A (ja) * | 2017-07-14 | 2020-08-31 | フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ | 冷感調合物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3988433A (en) | 1973-08-10 | 1976-10-26 | The Procter & Gamble Company | Oral compositions for preventing or removing stains from teeth |
| US4083955A (en) | 1975-04-02 | 1978-04-11 | The Procter & Gamble Company | Processes and compositions for remineralization of dental enamel |
| US4528180A (en) | 1983-03-01 | 1985-07-09 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery thereof |
| US4849213A (en) | 1983-03-01 | 1989-07-18 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery therof |
| US5198220A (en) | 1989-11-17 | 1993-03-30 | The Procter & Gamble Company | Sustained release compositions for treating periodontal disease |
| US5281410A (en) | 1991-10-23 | 1994-01-25 | The Proctor & Gamble Company | Methods of reducing plaque and gingivitis with reduced staining |
| US5213790A (en) | 1991-10-23 | 1993-05-25 | The Procter & Gamble Co. | Methods of reducing plaque and gingivitis with reduced staining |
| US5145666A (en) | 1991-10-23 | 1992-09-08 | The Proctor & Gamble Co. | Methods of reducing plaque and gingivitis with reduced staining |
| US5242910A (en) | 1992-10-13 | 1993-09-07 | The Procter & Gamble Company | Sustained release compositions for treating periodontal disease |
| GB0704163D0 (en) | 2007-03-02 | 2007-04-11 | Quest Int Serv Bv | Compositions comprising a physiological coolant |
| AU2009318056B2 (en) | 2008-11-20 | 2014-07-24 | The Procter & Gamble Company | Personal care compositions providing enhanced cooling sensation |
| US20160339026A1 (en) * | 2015-10-02 | 2016-11-24 | Senomyx, Inc. | Topical compositions comprising modulators of trpm8 |
| EP3675809B1 (de) * | 2017-08-31 | 2023-09-27 | Basf Se | Verwendung physiologischer kühlwirkstoffe und mittel enthaltend solche wirkstoffe |
| WO2019121193A1 (en) | 2017-12-21 | 2019-06-27 | Firmenich Sa | Cooling and flavor boosting compositions |
| US12528801B2 (en) | 2019-10-17 | 2026-01-20 | Givaudan Sa | Substituted azacyles as TRPM8 modulators |
-
2021
- 2021-02-09 WO PCT/CN2021/076366 patent/WO2022170519A1/en not_active Ceased
-
2022
- 2022-02-09 US US18/276,412 patent/US20240139087A1/en active Pending
- 2022-02-09 EP EP22705763.5A patent/EP4291553A1/en active Pending
- 2022-02-09 CN CN202280013860.1A patent/CN116867775A/zh active Pending
- 2022-02-09 WO PCT/EP2022/053085 patent/WO2022171653A1/en not_active Ceased
- 2022-02-09 JP JP2023547811A patent/JP2024505595A/ja active Pending
- 2022-02-09 MX MX2023008005A patent/MX2023008005A/es unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016172769A (ja) * | 2010-11-05 | 2016-09-29 | セノミックス インコーポレイテッド | Ｔｒｐｍ８の活性調節因子として有用な化合物 |
| JP2018535937A (ja) * | 2015-10-01 | 2018-12-06 | セノミックス インコーポレイテッドＳｅｎｏｍｙｘ， Ｉｎｃ． | Ｔｒｐｍ８の活性調節因子として有用な化合物 |
| JP2020526632A (ja) * | 2017-07-14 | 2020-08-31 | フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ | 冷感調合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20240139087A1 (en) | 2024-05-02 |
| WO2022170519A1 (en) | 2022-08-18 |
| EP4291553A1 (en) | 2023-12-20 |
| CN116867775A (zh) | 2023-10-10 |
| MX2023008005A (es) | 2023-07-13 |
| WO2022171653A1 (en) | 2022-08-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12528801B2 (en) | Substituted azacyles as TRPM8 modulators | |
| JP2024505595A (ja) | Ｔｒｐｍ８アクチベーターとしての有機化合物 | |
| JP7835730B2 (ja) | 冷却感覚組成物 | |
| EP4065566B1 (en) | Trpm8 modulators | |
| JP7769625B2 (ja) | Ｔｒｐｍ８アンタゴニストとしての複素環式誘導体 | |
| RU2839995C1 (ru) | Замещенные азацилы в качестве модуляторов trpm8 | |
| WO2022223661A1 (en) | Compounds with cooling sensation properties |
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