CN116867775A - 作为trpm8激活剂的有机化合物 - Google Patents

作为trpm8激活剂的有机化合物 Download PDF

Info

Publication number
CN116867775A
CN116867775A CN202280013860.1A CN202280013860A CN116867775A CN 116867775 A CN116867775 A CN 116867775A CN 202280013860 A CN202280013860 A CN 202280013860A CN 116867775 A CN116867775 A CN 116867775A
Authority
CN
China
Prior art keywords
alkyl group
alkyl
hydrogen
imidazol
tolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280013860.1A
Other languages
English (en)
Chinese (zh)
Inventor
N·寇希拓阿玛尼诺
周丽君
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Givaudan SA
Original Assignee
Givaudan SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Givaudan SA filed Critical Givaudan SA
Publication of CN116867775A publication Critical patent/CN116867775A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/24—Thermal properties
    • A61K2800/244—Endothermic; Cooling; Cooling sensation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Confectionery (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
CN202280013860.1A 2021-02-09 2022-02-09 作为trpm8激活剂的有机化合物 Pending CN116867775A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2021/076366 2021-02-09
PCT/CN2021/076366 WO2022170519A1 (en) 2021-02-09 2021-02-09 Organic compounds
PCT/EP2022/053085 WO2022171653A1 (en) 2021-02-09 2022-02-09 Organic compounds as trpm8 activators

Publications (1)

Publication Number Publication Date
CN116867775A true CN116867775A (zh) 2023-10-10

Family

ID=80447119

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280013860.1A Pending CN116867775A (zh) 2021-02-09 2022-02-09 作为trpm8激活剂的有机化合物

Country Status (6)

Country Link
US (1) US20240139087A1 (https=)
EP (1) EP4291553A1 (https=)
JP (1) JP2024505595A (https=)
CN (1) CN116867775A (https=)
MX (1) MX2023008005A (https=)
WO (2) WO2022170519A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4583718A1 (en) 2022-10-27 2025-07-16 Firmenich SA Flavonoid compositions and uses thereof
WO2024132554A1 (en) 2022-12-22 2024-06-27 Firmenich Sa Natural sweetener compositions and uses thereof
WO2024132552A1 (en) 2022-12-22 2024-06-27 Firmenich Sa Natural sweetener compositions containing alkyl lactates and uses thereof
JP2026511252A (ja) 2023-03-28 2026-04-10 フイルメニツヒ ソシエテ アノニム 味改変組成物およびその使用
WO2025202256A1 (en) * 2024-03-28 2025-10-02 Firmenich Sa Cooling composition

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200190052A1 (en) * 2017-08-31 2020-06-18 Basf Se Use of physiological cooling active ingredients, and compositions comprising such active ingredients

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3988433A (en) 1973-08-10 1976-10-26 The Procter & Gamble Company Oral compositions for preventing or removing stains from teeth
US4083955A (en) 1975-04-02 1978-04-11 The Procter & Gamble Company Processes and compositions for remineralization of dental enamel
US4528180A (en) 1983-03-01 1985-07-09 Schaeffer Hans A Dental preparation, article and method for storage and delivery thereof
US4849213A (en) 1983-03-01 1989-07-18 Schaeffer Hans A Dental preparation, article and method for storage and delivery therof
US5198220A (en) 1989-11-17 1993-03-30 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5281410A (en) 1991-10-23 1994-01-25 The Proctor & Gamble Company Methods of reducing plaque and gingivitis with reduced staining
US5213790A (en) 1991-10-23 1993-05-25 The Procter & Gamble Co. Methods of reducing plaque and gingivitis with reduced staining
US5145666A (en) 1991-10-23 1992-09-08 The Proctor & Gamble Co. Methods of reducing plaque and gingivitis with reduced staining
US5242910A (en) 1992-10-13 1993-09-07 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
GB0704163D0 (en) 2007-03-02 2007-04-11 Quest Int Serv Bv Compositions comprising a physiological coolant
AU2009318056B2 (en) 2008-11-20 2014-07-24 The Procter & Gamble Company Personal care compositions providing enhanced cooling sensation
DE202011110963U1 (de) * 2010-11-05 2017-11-07 Senomyx, Inc. Verbindungen, die als Modulatoren von TRPM8 nützlich sind
MX389514B (es) * 2015-10-01 2025-03-20 Firmenich Incorporated Compuestos útiles como moduladores de canal receptor 8 de potencial transitorio de melastatina (trpm8).
US20160339026A1 (en) * 2015-10-02 2016-11-24 Senomyx, Inc. Topical compositions comprising modulators of trpm8
JP7222969B2 (ja) * 2017-07-14 2023-02-15 フイルメニツヒ ソシエテ アノニム 冷感調合物
WO2019121193A1 (en) 2017-12-21 2019-06-27 Firmenich Sa Cooling and flavor boosting compositions
US12528801B2 (en) 2019-10-17 2026-01-20 Givaudan Sa Substituted azacyles as TRPM8 modulators

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200190052A1 (en) * 2017-08-31 2020-06-18 Basf Se Use of physiological cooling active ingredients, and compositions comprising such active ingredients

Also Published As

Publication number Publication date
JP2024505595A (ja) 2024-02-06
US20240139087A1 (en) 2024-05-02
WO2022170519A1 (en) 2022-08-18
EP4291553A1 (en) 2023-12-20
MX2023008005A (es) 2023-07-13
WO2022171653A1 (en) 2022-08-18

Similar Documents

Publication Publication Date Title
CN114555594B (zh) 作为trmp8调节剂的取代的氮杂环
CN116867775A (zh) 作为trpm8激活剂的有机化合物
JP7835730B2 (ja) 冷却感覚組成物
CN114761385B (zh) Trpm8调节剂
CN115243764B (zh) 作为trmp8拮抗剂的杂环衍生物
RU2839995C1 (ru) Замещенные азацилы в качестве модуляторов trpm8
WO2022223661A1 (en) Compounds with cooling sensation properties

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination