JP2024503002A - 皮質興奮性ニューロンの生成方法 - Google Patents

皮質興奮性ニューロンの生成方法 Download PDF

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JP2024503002A
JP2024503002A JP2023541288A JP2023541288A JP2024503002A JP 2024503002 A JP2024503002 A JP 2024503002A JP 2023541288 A JP2023541288 A JP 2023541288A JP 2023541288 A JP2023541288 A JP 2023541288A JP 2024503002 A JP2024503002 A JP 2024503002A
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inhibitor
cells
stem cells
certain embodiments
signaling
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JP2024503002A5 (https=
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ローレンツ ステューダー，
ガブリエーレ チチェリ，
Original Assignee
メモリアル スローン－ケタリング キャンサー センター
スローン － ケタリング・インスティテュート・フォー・キャンサー・リサーチ
メモリアル ホスピタル フォー キャンサー アンド アライド ディジージズ
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Publication of JP2024503002A publication Critical patent/JP2024503002A/ja
Publication of JP2024503002A5 publication Critical patent/JP2024503002A5/ja
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    • A—HUMAN NECESSITIES
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    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
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    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

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JP2023541288A 2021-01-07 2022-01-07 皮質興奮性ニューロンの生成方法 Pending JP2024503002A (ja)

Applications Claiming Priority (3)

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US202163134651P 2021-01-07 2021-01-07
US63/134,651 2021-01-07
PCT/US2022/011539 WO2022150541A1 (en) 2021-01-07 2022-01-07 Methods of generating cortical excitatory neurons

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JP2024503002A true JP2024503002A (ja) 2024-01-24
JP2024503002A5 JP2024503002A5 (https=) 2025-01-15

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US (1) US20240050486A1 (https=)
EP (1) EP4274421A4 (https=)
JP (1) JP2024503002A (https=)
CA (1) CA3204035A1 (https=)
WO (1) WO2022150541A1 (https=)

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TW202417614A (zh) * 2022-08-23 2024-05-01 安斯泰來再生醫藥協會 用於治療眼部病症的感光救援細胞（prc）組成物及方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019506901A (ja) * 2016-01-27 2019-03-14 メモリアル スローン ケタリング キャンサー センター ヒト人工多能性幹細胞からの皮質ニューロンの分化
US20190367868A1 (en) * 2015-12-31 2019-12-05 President And Fellows Of Harvard College Neurons and compositions and methods for producing the same

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Publication number Priority date Publication date Assignee Title
EP2028268A1 (en) * 2007-08-20 2009-02-25 Université Libre De Bruxelles Generation of neuronal cells from pluripotent stem cells
CA2899507A1 (en) * 2013-03-14 2014-09-25 The Regents Of The University Of California In vitro production of medial ganglionic eminence precursor cells
EP3498824A1 (en) * 2013-04-26 2019-06-19 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190367868A1 (en) * 2015-12-31 2019-12-05 President And Fellows Of Harvard College Neurons and compositions and methods for producing the same
JP2019506901A (ja) * 2016-01-27 2019-03-14 メモリアル スローン ケタリング キャンサー センター ヒト人工多能性幹細胞からの皮質ニューロンの分化

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EIRAKU M. ET AL.: "Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extr", CELL STEM CELL, vol. 3, no. 5, JPN7025005629, 6 November 2008 (2008-11-06), pages 519 - 32, ISSN: 0005762464 *

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US20240050486A1 (en) 2024-02-15
EP4274421A1 (en) 2023-11-15
CA3204035A1 (en) 2022-07-14
WO2022150541A8 (en) 2023-08-03
WO2022150541A1 (en) 2022-07-14
EP4274421A4 (en) 2025-03-26

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