JP2024502740A - 長時間作用型グルカゴン様ポリペプチド－１（ｇｌｐ－１）受容体アゴニスト及び使用方法 - Google Patents

長時間作用型グルカゴン様ポリペプチド－１（ｇｌｐ－１）受容体アゴニスト及び使用方法 Download PDF

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Publication number
JP2024502740A
JP2024502740A JP2023537184A JP2023537184A JP2024502740A JP 2024502740 A JP2024502740 A JP 2024502740A JP 2023537184 A JP2023537184 A JP 2023537184A JP 2023537184 A JP2023537184 A JP 2023537184A JP 2024502740 A JP2024502740 A JP 2024502740A
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Japan
Prior art keywords
isolated polypeptide
spacer
positions
aib
lipophilic substituent
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JP2023537184A
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English (en)
Japanese (ja)
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JPWO2022133148A5 (https=
JP2024502740A5 (https=
Inventor
ウィリアム・ブラックウェル
ヴェド・ピー・スリヴァスタヴァ
マーク・ポーリック
Original Assignee
アイツーオー・セラピューティクス・インコーポレイテッド
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Publication of JP2024502740A publication Critical patent/JP2024502740A/ja
Publication of JPWO2022133148A5 publication Critical patent/JPWO2022133148A5/ja
Publication of JP2024502740A5 publication Critical patent/JP2024502740A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2023537184A 2020-12-17 2021-12-16 長時間作用型グルカゴン様ポリペプチド－１（ｇｌｐ－１）受容体アゴニスト及び使用方法 Pending JP2024502740A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063126736P 2020-12-17 2020-12-17
US63/126,736 2020-12-17
PCT/US2021/063920 WO2022133148A1 (en) 2020-12-17 2021-12-16 Long acting glucagon like polypeptide-1 (glp-1) receptor agonists and methods of use

Publications (3)

Publication Number Publication Date
JP2024502740A true JP2024502740A (ja) 2024-01-23
JPWO2022133148A5 JPWO2022133148A5 (https=) 2024-12-23
JP2024502740A5 JP2024502740A5 (https=) 2024-12-23

Family

ID=80123475

Family Applications (1)

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JP2023537184A Pending JP2024502740A (ja) 2020-12-17 2021-12-16 長時間作用型グルカゴン様ポリペプチド－１（ｇｌｐ－１）受容体アゴニスト及び使用方法

Country Status (12)

Country Link
US (2) US12084485B2 (https=)
EP (1) EP4263587A1 (https=)
JP (1) JP2024502740A (https=)
KR (1) KR20230156689A (https=)
CN (1) CN116917311A (https=)
AR (1) AR124395A1 (https=)
AU (1) AU2021400738A1 (https=)
CA (1) CA3202389A1 (https=)
IL (1) IL303686A (https=)
MX (1) MX2023007224A (https=)
TW (1) TW202237628A (https=)
WO (1) WO2022133148A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022159395A1 (en) 2021-01-20 2022-07-28 Viking Therapeutics, Inc. Compositions and methods for the treatment of metabolic and liver disorders
MX2024003236A (es) 2021-09-15 2024-06-19 Viking Therapeutics Inc Composiciones y metodos para el tratamiento de trastornos metabolicos y hepaticos.
AU2024218747A1 (en) * 2023-02-10 2025-08-28 Hangzhou Sciwind Biosciences Co., Ltd. Polypeptide and derivative thereof, composition, and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019525732A (ja) * 2016-06-09 2019-09-12 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ プロテアーゼ耐性一脂質付加ペプチド

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100256056A1 (en) 2007-09-07 2010-10-07 Zheng Xin Dong Analogues of exendin-4 and exendin-3
SMT201700583T1 (it) 2009-09-28 2018-01-11 Intarcia Therapeutics Inc Instaurazione e/o terminazione rapida di erogazione di farmaci in modo sostanzialmente stazionario
JP6165168B2 (ja) * 2011-12-22 2017-07-19 ファイザー・インク 抗糖尿病化合物
UA116217C2 (uk) * 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
RU2760007C2 (ru) * 2016-05-16 2021-11-22 Интарсия Терапьютикс, Инк. Полипептиды, селективные к рецепторам глюкагона, и способы их применения
CN111333714A (zh) 2020-03-05 2020-06-26 成都奥达生物科技有限公司 一种长效glp-1化合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019525732A (ja) * 2016-06-09 2019-09-12 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ プロテアーゼ耐性一脂質付加ペプチド

Also Published As

Publication number Publication date
AR124395A1 (es) 2023-03-22
MX2023007224A (es) 2023-09-05
CA3202389A1 (en) 2022-06-23
WO2022133148A1 (en) 2022-06-23
IL303686A (en) 2023-08-01
US20250034225A1 (en) 2025-01-30
AU2021400738A1 (en) 2023-07-13
TW202237628A (zh) 2022-10-01
KR20230156689A (ko) 2023-11-14
US12084485B2 (en) 2024-09-10
US20230063420A1 (en) 2023-03-02
CN116917311A (zh) 2023-10-20
EP4263587A1 (en) 2023-10-25

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