JP2024500324A - Ｇｌｐ－１ｒおよびｇｃｇｒ均衡アゴニストを使用した血糖および／または体重を低下させるための治療レジメンおよび方法 - Google Patents

Ｇｌｐ－１ｒおよびｇｃｇｒ均衡アゴニストを使用した血糖および／または体重を低下させるための治療レジメンおよび方法 Download PDF

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JP2024500324A
JP2024500324A JP2023534386A JP2023534386A JP2024500324A JP 2024500324 A JP2024500324 A JP 2024500324A JP 2023534386 A JP2023534386 A JP 2023534386A JP 2023534386 A JP2023534386 A JP 2023534386A JP 2024500324 A JP2024500324 A JP 2024500324A
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クリシュナン，ヴィジャヤンティ
ジェームズ，ジョイス
オルハヤ，オマー
スコット ハリス，マシュー
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スピットファイア ファーマ エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2023534386A 2020-12-07 2021-12-07 Ｇｌｐ－１ｒおよびｇｃｇｒ均衡アゴニストを使用した血糖および／または体重を低下させるための治療レジメンおよび方法 Pending JP2024500324A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063122117P 2020-12-07 2020-12-07
US63/122,117 2020-12-07
US202163211157P 2021-06-16 2021-06-16
US63/211,157 2021-06-16
US202163249468P 2021-09-28 2021-09-28
US63/249,468 2021-09-28
PCT/US2021/062286 WO2022125598A1 (en) 2020-12-07 2021-12-07 Therapeutic regimens and methods for lowering blood glucose and or body weight using glp-1r and gcgr balanced agonists

Publications (2)

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JP2024500324A true JP2024500324A (ja) 2024-01-09
JP2024500324A5 JP2024500324A5 (https=) 2024-11-20

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JP2023534386A Pending JP2024500324A (ja) 2020-12-07 2021-12-07 Ｇｌｐ－１ｒおよびｇｃｇｒ均衡アゴニストを使用した血糖および／または体重を低下させるための治療レジメンおよび方法

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Country Link
US (1) US20250134963A1 (https=)
EP (1) EP4255564A4 (https=)
JP (1) JP2024500324A (https=)
KR (1) KR20230129425A (https=)
CA (1) CA3201539A1 (https=)
IL (1) IL303512A (https=)
MX (1) MX2023006736A (https=)
WO (1) WO2022125598A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240269238A1 (en) * 2022-09-14 2024-08-15 Spitfire Pharma Llc Therapeutic Regimens and Methods for Reducing Body Weight in a Subject with Fatty Liver Disease using a GLP-1R and GCGR Agonist
JP2025537192A (ja) * 2022-11-05 2025-11-14 スピットファイア ファーマ エルエルシー Ｇｌｐ－１ｒおよびｇｃｇｒアゴニストを使用した心血管リスク因子の処置のための治療レジメンおよび方法
WO2025098416A1 (zh) * 2023-11-06 2025-05-15 甘李药业股份有限公司 用于减肥的glp-1化合物
WO2025193765A1 (en) * 2024-03-12 2025-09-18 Spitfire Pharma Llc Therapeutic regimens and methods for reducing body weight and/or serum lipids using a glp-1r and gcgr agonist
CN118477048B (zh) * 2024-05-24 2024-12-17 山东泰合医药科技有限公司 一种布瑞哌唑缓释微球及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017519739A (ja) * 2014-05-28 2017-07-20 メデリス ダイアビーティーズ，エルエルシー インスリン抵抗性のための改善されたペプチド医薬品
JP2019510014A (ja) * 2016-03-10 2019-04-11 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ 肥満の治療のためのグルカゴン及びｇｌｐ−１コアゴニスト
WO2019136158A1 (en) * 2018-01-03 2019-07-11 Spitfire Pharma, Inc. Improved peptide pharmaceuticals for treatment of nash and other disorders
WO2020109526A2 (en) * 2018-11-30 2020-06-04 Opko Ireland Global Holdings, Ltd. Oxyntomodulin peptide analog formulations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011506442A (ja) * 2007-12-11 2011-03-03 コンジュケム バイオテクノロジーズ インコーポレイテッド インスリン分泌性ペプチド結合体の製剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017519739A (ja) * 2014-05-28 2017-07-20 メデリス ダイアビーティーズ，エルエルシー インスリン抵抗性のための改善されたペプチド医薬品
JP2019510014A (ja) * 2016-03-10 2019-04-11 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ 肥満の治療のためのグルカゴン及びｇｌｐ−１コアゴニスト
WO2019136158A1 (en) * 2018-01-03 2019-07-11 Spitfire Pharma, Inc. Improved peptide pharmaceuticals for treatment of nash and other disorders
WO2020109526A2 (en) * 2018-11-30 2020-06-04 Opko Ireland Global Holdings, Ltd. Oxyntomodulin peptide analog formulations

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Altimmune Signs Definitive Agreement to Acquire Spitfire Pharma, Inc. Adding NASH Drug Candidate to", [ONLINE], JPN6025034812, 9 July 2019 (2019-07-09), ISSN: 0005805991 *
PETERSEN, J. ET AL.: "Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities", DRUGS, vol. 79, no. 11, JPN6025034816, 2019, pages 1187 - 1197, ISSN: 0005670487 *

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Publication number Publication date
CA3201539A1 (en) 2022-06-16
MX2023006736A (es) 2023-08-21
WO2022125598A1 (en) 2022-06-16
KR20230129425A (ko) 2023-09-08
IL303512A (en) 2023-08-01
EP4255564A4 (en) 2024-11-06
EP4255564A1 (en) 2023-10-11
US20250134963A1 (en) 2025-05-01

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