JP2024071489A5 - - Google Patents
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- JP2024071489A5 JP2024071489A5 JP2024046338A JP2024046338A JP2024071489A5 JP 2024071489 A5 JP2024071489 A5 JP 2024071489A5 JP 2024046338 A JP2024046338 A JP 2024046338A JP 2024046338 A JP2024046338 A JP 2024046338A JP 2024071489 A5 JP2024071489 A5 JP 2024071489A5
- Authority
- JP
- Japan
- Prior art keywords
- cell population
- aggregation
- guide rna
- tau
- relative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025185469A JP2026012398A (ja) | 2019-03-18 | 2025-11-04 | タウの播種または凝集の遺伝的修飾因子を同定するためのｃｒｉｓｐｒ／ｃａｓスクリーニングプラットフォーム |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962820086P | 2019-03-18 | 2019-03-18 | |
| US62/820,086 | 2019-03-18 | ||
| PCT/US2020/023131 WO2020190932A1 (en) | 2019-03-18 | 2020-03-17 | Crispr/cas screening platform to identify genetic modifiers of tau seeding or aggregation |
| JP2021556257A JP7461368B2 (ja) | 2019-03-18 | 2020-03-17 | タウの播種または凝集の遺伝的修飾因子を同定するためのｃｒｉｓｐｒ／ｃａｓスクリーニングプラットフォーム |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021556257A Division JP7461368B2 (ja) | 2019-03-18 | 2020-03-17 | タウの播種または凝集の遺伝的修飾因子を同定するためのｃｒｉｓｐｒ／ｃａｓスクリーニングプラットフォーム |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025185469A Division JP2026012398A (ja) | 2019-03-18 | 2025-11-04 | タウの播種または凝集の遺伝的修飾因子を同定するためのｃｒｉｓｐｒ／ｃａｓスクリーニングプラットフォーム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024071489A JP2024071489A (ja) | 2024-05-24 |
| JP2024071489A5 true JP2024071489A5 (enExample) | 2025-04-10 |
| JP7770447B2 JP7770447B2 (ja) | 2025-11-14 |
Family
ID=70285889
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021556257A Active JP7461368B2 (ja) | 2019-03-18 | 2020-03-17 | タウの播種または凝集の遺伝的修飾因子を同定するためのｃｒｉｓｐｒ／ｃａｓスクリーニングプラットフォーム |
| JP2024046338A Active JP7770447B2 (ja) | 2019-03-18 | 2024-03-22 | タウの播種または凝集の遺伝的修飾因子を同定するためのｃｒｉｓｐｒ／ｃａｓスクリーニングプラットフォーム |
| JP2025185469A Pending JP2026012398A (ja) | 2019-03-18 | 2025-11-04 | タウの播種または凝集の遺伝的修飾因子を同定するためのｃｒｉｓｐｒ／ｃａｓスクリーニングプラットフォーム |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021556257A Active JP7461368B2 (ja) | 2019-03-18 | 2020-03-17 | タウの播種または凝集の遺伝的修飾因子を同定するためのｃｒｉｓｐｒ／ｃａｓスクリーニングプラットフォーム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025185469A Pending JP2026012398A (ja) | 2019-03-18 | 2025-11-04 | タウの播種または凝集の遺伝的修飾因子を同定するためのｃｒｉｓｐｒ／ｃａｓスクリーニングプラットフォーム |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US11845931B2 (enExample) |
| EP (3) | EP4729947A3 (enExample) |
| JP (3) | JP7461368B2 (enExample) |
| KR (3) | KR20260032649A (enExample) |
| CN (2) | CN120648640A (enExample) |
| AU (2) | AU2020241858B2 (enExample) |
| CA (1) | CA3127813A1 (enExample) |
| ES (2) | ES2970541T3 (enExample) |
| IL (2) | IL312893A (enExample) |
| SG (1) | SG11202108091YA (enExample) |
| WO (1) | WO2020190932A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3769090B1 (en) | 2019-03-18 | 2023-11-15 | Regeneron Pharmaceuticals, Inc. | Crispr/cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation |
| CN120648640A (zh) | 2019-03-18 | 2025-09-16 | 瑞泽恩制药公司 | 用于鉴定tau接种或聚集的基因修饰因子的CRISPR/Cas筛选平台 |
| CN113906134B (zh) | 2019-06-14 | 2025-06-24 | 瑞泽恩制药公司 | Tau蛋白病模型 |
| WO2023046996A1 (en) * | 2021-09-27 | 2023-03-30 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Method for improved intron tagging and automated clone recognition |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT500379B8 (de) | 2001-02-02 | 2009-08-15 | Axon Neuroscience | Tau-proteine |
| JP2011517838A (ja) | 2008-04-11 | 2011-06-16 | ユーティーシー パワー コーポレイション | マニホルド・サンプを備えたバイポーラプレートおよび燃料電池 |
| US8586526B2 (en) | 2010-05-17 | 2013-11-19 | Sangamo Biosciences, Inc. | DNA-binding proteins and uses thereof |
| US9637739B2 (en) | 2012-03-20 | 2017-05-02 | Vilnius University | RNA-directed DNA cleavage by the Cas9-crRNA complex |
| WO2013141680A1 (en) | 2012-03-20 | 2013-09-26 | Vilnius University | RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX |
| AU2013266968B2 (en) | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| SG10201708959WA (en) | 2012-07-03 | 2017-11-29 | Univ Washington | Antibodies to tau |
| WO2014033644A2 (en) | 2012-08-28 | 2014-03-06 | Novartis Ag | Methods of nuclease-based genetic engineering |
| AU2013335451C1 (en) | 2012-10-23 | 2024-07-04 | Toolgen Incorporated | Composition for cleaving a target DNA comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof |
| US9910048B2 (en) | 2012-12-03 | 2018-03-06 | Washington University | Method for detection of aggregates in biological samples |
| PL3360964T3 (pl) | 2012-12-06 | 2020-03-31 | Sigma-Aldrich Co. Llc | Modyfikacja i regulacja genomu oparta na crispr |
| EP3031921B1 (en) | 2012-12-12 | 2025-03-12 | The Broad Institute, Inc. | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| EP2840140B2 (en) | 2012-12-12 | 2023-02-22 | The Broad Institute, Inc. | Crispr-Cas based method for mutation of prokaryotic cells |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| US20140186843A1 (en) | 2012-12-12 | 2014-07-03 | Massachusetts Institute Of Technology | Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
| EP2931899A1 (en) | 2012-12-12 | 2015-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| DK2931891T3 (da) | 2012-12-17 | 2019-08-19 | Harvard College | Rna-styret modificering af menneskelige genomer |
| EP2922393B2 (en) | 2013-02-27 | 2022-12-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Gene editing in the oocyte by cas9 nucleases |
| CN112301024A (zh) | 2013-03-15 | 2021-02-02 | 通用医疗公司 | 使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性 |
| EP4286517A3 (en) | 2013-04-04 | 2024-03-13 | President and Fellows of Harvard College | Therapeutic uses of genome editing with crispr/cas systems |
| US9267135B2 (en) | 2013-06-04 | 2016-02-23 | President And Fellows Of Harvard College | RNA-guided transcriptional regulation |
| EP3725885A1 (en) | 2013-06-17 | 2020-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof |
| WO2015048577A2 (en) | 2013-09-27 | 2015-04-02 | Editas Medicine, Inc. | Crispr-related methods and compositions |
| WO2015065964A1 (en) | 2013-10-28 | 2015-05-07 | The Broad Institute Inc. | Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof |
| JP2017512751A (ja) | 2014-02-14 | 2017-05-25 | アイピエリアン，インコーポレイティド | タウペプチド、抗タウ抗体、およびそれらの使用方法 |
| US20150376586A1 (en) | 2014-06-25 | 2015-12-31 | Caribou Biosciences, Inc. | RNA Modification to Engineer Cas9 Activity |
| SI3161128T1 (sl) * | 2014-06-26 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Postopki in sestavki za ciljano genetsko spremembo in postopki uporabe |
| CA2954791C (en) | 2014-07-14 | 2025-11-18 | The Regents Of The University Of California | CRISPR/CAS TRANSCRIPTIONAL MODULATION |
| WO2016049258A2 (en) | 2014-09-25 | 2016-03-31 | The Broad Institute Inc. | Functional screening with optimized functional crispr-cas systems |
| WO2016106236A1 (en) | 2014-12-23 | 2016-06-30 | The Broad Institute Inc. | Rna-targeting system |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| US10676735B2 (en) | 2015-07-22 | 2020-06-09 | Duke University | High-throughput screening of regulatory element function with epigenome editing technologies |
| AU2016365720B2 (en) | 2015-12-07 | 2020-11-26 | Arc Bio, Llc | Methods and compositions for the making and using of guide nucleic acids |
| WO2017124100A1 (en) * | 2016-01-14 | 2017-07-20 | Memphis Meats, Inc. | Methods for extending the replicative capacity of somatic cells during an ex vivo cultivation process |
| LT3436077T (lt) | 2016-03-30 | 2025-06-25 | Intellia Therapeutics, Inc. | Lipidų nanodalelių vaisto formos, skirtos crispr/cas komponentams |
| WO2017172764A1 (en) | 2016-04-01 | 2017-10-05 | The Regents Of The University Of California | Modified cell line and method of determining tauopathies |
| CN110267985B (zh) | 2017-01-04 | 2023-05-23 | H.隆德贝克有限公司 | 用于治疗眼科疾病的特异性针对过度磷酸化τ蛋白的抗体 |
| GB201708998D0 (en) | 2017-06-06 | 2017-07-19 | Univ Leuven Kath | Methods for identifying activators and suppressors |
| WO2019010384A1 (en) | 2017-07-07 | 2019-01-10 | The Broad Institute, Inc. | METHODS FOR DESIGNING GUIDE SEQUENCES FOR GUIDED NUCLEASES |
| CN110891420B (zh) | 2017-07-31 | 2022-06-03 | 瑞泽恩制药公司 | Cas转基因小鼠胚胎干细胞和小鼠及其应用 |
| EP3592140A1 (en) | 2018-03-19 | 2020-01-15 | Regeneron Pharmaceuticals, Inc. | Transcription modulation in animals using crispr/cas systems |
| CA3133983A1 (en) | 2019-03-18 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Methods and systems for crispr selection |
| CN120648640A (zh) | 2019-03-18 | 2025-09-16 | 瑞泽恩制药公司 | 用于鉴定tau接种或聚集的基因修饰因子的CRISPR/Cas筛选平台 |
| EP3769090B1 (en) | 2019-03-18 | 2023-11-15 | Regeneron Pharmaceuticals, Inc. | Crispr/cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation |
| CN113906134B (zh) | 2019-06-14 | 2025-06-24 | 瑞泽恩制药公司 | Tau蛋白病模型 |
-
2020
- 2020-03-17 CN CN202510881160.XA patent/CN120648640A/zh active Pending
- 2020-03-17 US US16/821,453 patent/US11845931B2/en active Active
- 2020-03-17 KR KR1020267005903A patent/KR20260032649A/ko active Pending
- 2020-03-17 KR KR1020217030636A patent/KR102695765B1/ko active Active
- 2020-03-17 SG SG11202108091YA patent/SG11202108091YA/en unknown
- 2020-03-17 EP EP25223891.0A patent/EP4729947A3/en active Pending
- 2020-03-17 ES ES20718950T patent/ES2970541T3/es active Active
- 2020-03-17 ES ES23215659T patent/ES3064222T3/es active Active
- 2020-03-17 AU AU2020241858A patent/AU2020241858B2/en active Active
- 2020-03-17 CA CA3127813A patent/CA3127813A1/en active Pending
- 2020-03-17 EP EP23215659.6A patent/EP4317950B1/en active Active
- 2020-03-17 CN CN202080021710.6A patent/CN113631700B/zh active Active
- 2020-03-17 IL IL312893A patent/IL312893A/en unknown
- 2020-03-17 IL IL286357A patent/IL286357B2/en unknown
- 2020-03-17 EP EP20718950.7A patent/EP3768826B1/en active Active
- 2020-03-17 JP JP2021556257A patent/JP7461368B2/ja active Active
- 2020-03-17 WO PCT/US2020/023131 patent/WO2020190932A1/en not_active Ceased
- 2020-03-17 KR KR1020247027001A patent/KR102933093B1/ko active Active
-
2023
- 2023-11-06 US US18/502,499 patent/US12209238B2/en active Active
-
2024
- 2024-03-22 JP JP2024046338A patent/JP7770447B2/ja active Active
- 2024-08-23 AU AU2024216321A patent/AU2024216321B2/en active Active
- 2024-12-17 US US18/984,162 patent/US12421512B2/en active Active
-
2025
- 2025-08-20 US US19/305,157 patent/US20260049305A1/en active Pending
- 2025-11-04 JP JP2025185469A patent/JP2026012398A/ja active Pending
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