JP2024029261A5 - - Google Patents
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- JP2024029261A5 JP2024029261A5 JP2024007290A JP2024007290A JP2024029261A5 JP 2024029261 A5 JP2024029261 A5 JP 2024029261A5 JP 2024007290 A JP2024007290 A JP 2024007290A JP 2024007290 A JP2024007290 A JP 2024007290A JP 2024029261 A5 JP2024029261 A5 JP 2024029261A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- isolated nucleic
- molecule
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000007523 nucleic acids Chemical class 0.000 claims 27
- 108020004707 nucleic acids Proteins 0.000 claims 24
- 102000039446 nucleic acids Human genes 0.000 claims 24
- 101100519207 Mus musculus Pdcd1 gene Proteins 0.000 claims 17
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 11
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 4
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 4
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 4
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 4
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 230000000903 blocking effect Effects 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 230000003827 upregulation Effects 0.000 claims 3
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 235000002198 Annona diversifolia Nutrition 0.000 claims 1
- 241000282842 Lama glama Species 0.000 claims 1
- 229940124060 PD-1 antagonist Drugs 0.000 claims 1
- 241001416177 Vicugna pacos Species 0.000 claims 1
- 230000006229 amino acid addition Effects 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 102000034287 fluorescent proteins Human genes 0.000 claims 1
- 108091006047 fluorescent proteins Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810255570.3 | 2018-03-20 | ||
| CN201810255570 | 2018-03-20 | ||
| CN2018079631 | 2018-03-20 | ||
| CNPCT/CN2018/079631 | 2018-03-20 | ||
| JP2020550711A JP7482031B2 (ja) | 2018-03-20 | 2019-03-18 | 新規の抗ｐｄ－１抗体 |
| PCT/CN2019/078515 WO2019179396A1 (en) | 2018-03-20 | 2019-03-18 | Novel anti-pd-1 antibodies |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020550711A Division JP7482031B2 (ja) | 2018-03-20 | 2019-03-18 | 新規の抗ｐｄ－１抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024029261A JP2024029261A (ja) | 2024-03-05 |
| JP2024029261A5 true JP2024029261A5 (https=) | 2024-08-15 |
Family
ID=67986701
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020550711A Active JP7482031B2 (ja) | 2018-03-20 | 2019-03-18 | 新規の抗ｐｄ－１抗体 |
| JP2024007290A Pending JP2024029261A (ja) | 2018-03-20 | 2024-01-22 | 新規の抗ｐｄ－１抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020550711A Active JP7482031B2 (ja) | 2018-03-20 | 2019-03-18 | 新規の抗ｐｄ－１抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US12030941B2 (https=) |
| EP (1) | EP3768724A4 (https=) |
| JP (2) | JP7482031B2 (https=) |
| CN (2) | CN116333126A (https=) |
| CA (1) | CA3093992A1 (https=) |
| TW (1) | TWI829677B (https=) |
| WO (1) | WO2019179396A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116333126A (zh) * | 2018-03-20 | 2023-06-27 | 上海药明生物技术有限公司 | 新型抗pd-1抗体 |
| CN112442122B (zh) * | 2019-09-04 | 2021-09-21 | 上海洛启生物医药技术有限公司 | 阻断型pd-1纳米抗体及其编码序列和用途 |
| CN114430746B (zh) * | 2019-09-25 | 2023-09-01 | 上海药明生物技术有限公司 | 新型抗pd-l1抗体 |
| WO2021063201A1 (zh) * | 2019-09-30 | 2021-04-08 | 四川科伦博泰生物医药股份有限公司 | 抗pd-1抗体及其用途 |
| BR112022023989A2 (pt) | 2020-05-26 | 2023-02-07 | Boehringer Ingelheim Int | Anticorpos anti-pd-1 |
| CN118240082A (zh) * | 2020-12-28 | 2024-06-25 | 浙江纳米抗体技术中心有限公司 | Pd-1结合分子及其应用 |
| US20240092908A1 (en) * | 2020-12-31 | 2024-03-21 | Zhejiang Doer Biologics Co., Ltd. | Anti-pd-1 single-domain antibody |
| WO2022161454A1 (zh) * | 2021-01-29 | 2022-08-04 | 明慧医药（杭州）有限公司 | 抗原结合蛋白及其用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2494107C2 (ru) * | 2005-05-09 | 2013-09-27 | Оно Фармасьютикал Ко., Лтд. | Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами |
| WO2009114335A2 (en) * | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| CN105061597B (zh) * | 2015-06-09 | 2016-04-27 | 北京东方百泰生物科技有限公司 | 一种抗pd-1的单克隆抗体及其获得方法 |
| CN106432494B9 (zh) | 2015-08-11 | 2022-02-15 | 广州誉衡生物科技有限公司 | 新型抗-pd-1抗体 |
| MA43260A (fr) * | 2015-11-18 | 2018-09-26 | Merck Sharp & Dohme | Liants pd1 et/ou lag3 |
| CN106046162B (zh) * | 2016-06-21 | 2019-04-02 | 大庆东竺明生物技术有限公司 | 抗人程序性死亡因子1（pd-1）单克隆抗体的制备及应用 |
| CN107474135B (zh) * | 2017-02-17 | 2020-08-18 | 广西医科大学 | 抗PD-1的纳米抗体PD-1/Nb20及其制备方法与应用 |
| AR114127A1 (es) * | 2018-03-02 | 2020-07-22 | Lilly Co Eli | Anticuerpos agonistas contra pd-1 y usos de estos |
| CN116333126A (zh) * | 2018-03-20 | 2023-06-27 | 上海药明生物技术有限公司 | 新型抗pd-1抗体 |
-
2019
- 2019-03-18 CN CN202211052114.1A patent/CN116333126A/zh active Pending
- 2019-03-18 CN CN201980020380.6A patent/CN112236454B/zh active Active
- 2019-03-18 WO PCT/CN2019/078515 patent/WO2019179396A1/en not_active Ceased
- 2019-03-18 US US16/981,336 patent/US12030941B2/en active Active
- 2019-03-18 JP JP2020550711A patent/JP7482031B2/ja active Active
- 2019-03-18 CA CA3093992A patent/CA3093992A1/en active Pending
- 2019-03-18 TW TW108109186A patent/TWI829677B/zh active
- 2019-03-18 EP EP19771635.0A patent/EP3768724A4/en active Pending
-
2024
- 2024-01-22 JP JP2024007290A patent/JP2024029261A/ja active Pending
- 2024-05-24 US US18/674,733 patent/US20240301067A1/en active Pending
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