JP2023545830A - 組換えアデノ随伴ウイルス組成物及びその生産方法 - Google Patents

組換えアデノ随伴ウイルス組成物及びその生産方法 Download PDF

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JP2023545830A
JP2023545830A JP2023523244A JP2023523244A JP2023545830A JP 2023545830 A JP2023545830 A JP 2023545830A JP 2023523244 A JP2023523244 A JP 2023523244A JP 2023523244 A JP2023523244 A JP 2023523244A JP 2023545830 A JP2023545830 A JP 2023545830A
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therapeutic composition
raav
approximately
cells
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JP2023545830A5 (enExample
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ダイ，ヨン
ジョウ，ジンミン
ダニエルズ，ギャレット
チャン，ジョナサン
ヘラー，ジョージ
ネルソン，スチュアート
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Prevail Therapeutics Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61K38/46—Hydrolases (3)
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JP2023523244A 2020-10-15 2021-10-15 組換えアデノ随伴ウイルス組成物及びその生産方法 Pending JP2023545830A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063092179P 2020-10-15 2020-10-15
US63/092,179 2020-10-15
PCT/US2021/055243 WO2022082017A2 (en) 2020-10-15 2021-10-15 Recombinant adeno-associated virus compositions and methods for producing same

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JP2023545830A true JP2023545830A (ja) 2023-10-31
JP2023545830A5 JP2023545830A5 (enExample) 2024-10-24

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US (1) US20220119843A1 (enExample)
EP (1) EP4229206A2 (enExample)
JP (1) JP2023545830A (enExample)
KR (1) KR20230088393A (enExample)
CN (1) CN116710567A (enExample)
AU (1) AU2021359852A1 (enExample)
CA (1) CA3198675A1 (enExample)
IL (1) IL302109A (enExample)
MX (1) MX2023004420A (enExample)
WO (1) WO2022082017A2 (enExample)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
CN120077057A (zh) 2022-10-04 2025-05-30 伊莱利利公司 Trem2相关疾病和病症的基因治疗
AR131035A1 (es) 2022-11-11 2025-02-12 Lilly Co Eli Ácidos nucleicos sintéticos que incluyen constructos promotores dirigidos a astrocitos y métodos de uso de los mismos
CN116350801A (zh) * 2022-11-22 2023-06-30 四川至善唯新生物科技有限公司 一种重组腺相关病毒载体的药物组合物及其用途
TW202432839A (zh) * 2022-12-06 2024-08-16 美商再生元醫藥公司 用於確定病毒載體基因體滴度之液滴式數位ｐｃｒ分析
WO2025190864A1 (en) * 2024-03-11 2025-09-18 Sartorius Stedim Biotech Gmbh Improved cell lysis methods, reagents, and kits for viral vector release and production
WO2026043765A1 (en) 2024-08-21 2026-02-26 Eli Lilly And Company Engineered regulatory splice elements for gene therapies

Citations (6)

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Publication number Priority date Publication date Assignee Title
WO2007084773A2 (en) * 2006-01-20 2007-07-26 University Of North Carolina At Chapel Hill Enhanced production of infectious parvovirus vectors in insect cells
US20180155697A1 (en) * 2015-12-24 2018-06-07 Wuhan Institute Of Physics And Mathematics, Chinese Academy Of Sciences Method of preparing recombinant adeno-associated virus and recombinant baculovirus
WO2019070894A1 (en) * 2017-10-03 2019-04-11 Prevail Therapeutics, Inc. GENE THERAPIES FOR LYSOSOMIAL DISORDERS
WO2019094253A1 (en) * 2017-11-08 2019-05-16 Avexis Inc. Means and method for preparing viral vectors and uses of same
US20200231954A1 (en) * 2017-10-03 2020-07-23 Prevail Therapeutics, Inc. Gene therapies for lysosomal disorders
US20200316221A1 (en) * 2016-10-13 2020-10-08 University Of Massachusetts Aav capsid designs

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EP1463805B1 (en) 2001-12-17 2014-10-22 The Trustees of The University of Pennsylvania Adeno-associated virus (aav) serotype 9 sequences, vectors containing same, and uses therefor
EP3387138B2 (en) * 2015-12-11 2026-05-27 The Trustees Of The University Of Pennsylvania Scalable purification method for aav9
MX2020004005A (es) 2017-10-03 2020-10-05 Prevail Therapeutics Inc Terapias genicas para los trastornos lisosomales.
AU2018354195A1 (en) 2017-10-23 2020-06-04 Prevail Therapeutics, Inc. Gene therapies for neurodegenerative disease

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007084773A2 (en) * 2006-01-20 2007-07-26 University Of North Carolina At Chapel Hill Enhanced production of infectious parvovirus vectors in insect cells
US20180155697A1 (en) * 2015-12-24 2018-06-07 Wuhan Institute Of Physics And Mathematics, Chinese Academy Of Sciences Method of preparing recombinant adeno-associated virus and recombinant baculovirus
US20200316221A1 (en) * 2016-10-13 2020-10-08 University Of Massachusetts Aav capsid designs
WO2019070894A1 (en) * 2017-10-03 2019-04-11 Prevail Therapeutics, Inc. GENE THERAPIES FOR LYSOSOMIAL DISORDERS
US20200231954A1 (en) * 2017-10-03 2020-07-23 Prevail Therapeutics, Inc. Gene therapies for lysosomal disorders
WO2019094253A1 (en) * 2017-11-08 2019-05-16 Avexis Inc. Means and method for preparing viral vectors and uses of same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NOVEMBER, MOLECULAR THERAPY, vol. Volume 17 Issue 11, JPN6025031839, 2009, pages 1888 - 1896, ISSN: 0005880590 *

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EP4229206A2 (en) 2023-08-23
WO2022082017A3 (en) 2022-07-21
CA3198675A1 (en) 2022-04-21
US20220119843A1 (en) 2022-04-21
WO2022082017A2 (en) 2022-04-21
KR20230088393A (ko) 2023-06-19
WO2022082017A9 (en) 2022-10-13
AU2021359852A9 (en) 2025-03-27
MX2023004420A (es) 2023-07-05
AU2021359852A1 (en) 2023-06-08
IL302109A (en) 2023-06-01
CN116710567A (zh) 2023-09-05

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