JP2023545229A - 抗ｖｅｇｆ実体および負の補体調節因子をコードする核酸、ならびに加齢黄斑変性の処置のためのその使用 - Google Patents

抗ｖｅｇｆ実体および負の補体調節因子をコードする核酸、ならびに加齢黄斑変性の処置のためのその使用 Download PDF

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JP2023545229A
JP2023545229A JP2022573176A JP2022573176A JP2023545229A JP 2023545229 A JP2023545229 A JP 2023545229A JP 2022573176 A JP2022573176 A JP 2022573176A JP 2022573176 A JP2022573176 A JP 2022573176A JP 2023545229 A JP2023545229 A JP 2023545229A
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complement
vector
vegf
polynucleotide
amd
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JP2023545229A5 (enExample
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ジョエル，ジョセフィーヌ
エスティーブ－ルッド，ジュリアン
タム，ローレンス
エリス，スコット
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ジャイロスコープ・セラピューティクス・リミテッド
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Priority claimed from GBGB2104148.8A external-priority patent/GB202104148D0/en
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K2227/10—Mammal
    • A01K2227/105—Murine
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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JP2022573176A 2020-10-16 2021-10-18 抗ｖｅｇｆ実体および負の補体調節因子をコードする核酸、ならびに加齢黄斑変性の処置のためのその使用 Pending JP2023545229A (ja)

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GBGB2016463.8A GB202016463D0 (en) 2020-10-16 2020-10-16 Product
GB2016463.8 2020-10-16
GBGB2104148.8A GB202104148D0 (en) 2021-03-24 2021-03-24 Product
GB2104148.8 2021-03-24
PCT/GB2021/052689 WO2022079453A1 (en) 2020-10-16 2021-10-18 Nucleic acid encoding an anti-vegf entity and a negative complement regulator and uses thereof for the treatment of age-related macular degeneration

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JP2023545229A true JP2023545229A (ja) 2023-10-27
JP2023545229A5 JP2023545229A5 (enExample) 2024-10-28

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EP (1) EP4229076A1 (enExample)
JP (1) JP2023545229A (enExample)
KR (1) KR20230088630A (enExample)
CN (1) CN119585299A (enExample)
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GB201800620D0 (en) 2018-01-15 2018-02-28 Univ Manchester C3b Binding Polypeptide
GB201821089D0 (en) 2018-12-21 2019-02-06 Gyroscope Therapeutics Ltd Codon-optimised complement factor I
JP7842082B2 (ja) * 2020-07-21 2026-04-07 エフティージェン コーポレーション 眼疾患を処置するための組成物および方法
WO2025083169A1 (en) * 2023-10-17 2025-04-24 Tenpoint Therapeutics Limited Combination of a vegf inhibitor and a complement pathway inhibitor for treating ocular disorders
KR20260004635A (ko) * 2024-07-01 2026-01-09 삼성바이오에피스 주식회사 애플리버셉트를 암호화하는 코돈-최적화된 폴리뉴클레오티드를 포함하는 발현 카세트 및 이를 포함하는 rAAV 생산용 플라스미드

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JP2015500811A (ja) * 2011-12-01 2015-01-08 プロテボビオ， インコーポレイテッド 補体経路およびｖｅｇｆ経路に対するタンパク質インヒビターおよびそれらの使用方法
WO2019079494A1 (en) * 2017-10-18 2019-04-25 Regenxbio, Inc. TREATMENT OF OCULAR DISEASES AND METASTATIC COLON CANCER WITH A VEGF TRAP WITH HUMAN POST-TRANSLATIONAL MODIFICATION
WO2020128516A2 (en) * 2018-12-21 2020-06-25 Gyroscope Therapeutics Limited Codon-optimised complement factor i

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ES2714007T3 (es) 2007-04-09 2019-05-24 Univ Florida Composiciones de vectores rAAV que tienen proteínas de la cápside modificadas en tirosina y métodos para su uso
SG11201808426XA (en) * 2016-04-15 2018-10-30 Univ Pennsylvania Compositions for treatment of wet age-related macular degeneration
EP3697920A4 (en) * 2017-10-20 2022-03-02 Gemini Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION
US12558434B2 (en) 2018-02-20 2026-02-24 The Trustees Of The University Of Pennsylvania Compositions for treatment of wet age-related macular degeneration
GB201821082D0 (en) * 2018-12-21 2019-02-06 Gyroscope Therapeutics Ltd Combination of complement factors i and h, and vector encoding thereof
WO2021081395A1 (en) * 2019-10-23 2021-04-29 Gemini Therapeutics Inc. Methods for treating patients having cfh mutations with recombinant cfh proteins

Patent Citations (3)

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JP2015500811A (ja) * 2011-12-01 2015-01-08 プロテボビオ， インコーポレイテッド 補体経路およびｖｅｇｆ経路に対するタンパク質インヒビターおよびそれらの使用方法
WO2019079494A1 (en) * 2017-10-18 2019-04-25 Regenxbio, Inc. TREATMENT OF OCULAR DISEASES AND METASTATIC COLON CANCER WITH A VEGF TRAP WITH HUMAN POST-TRANSLATIONAL MODIFICATION
WO2020128516A2 (en) * 2018-12-21 2020-06-25 Gyroscope Therapeutics Limited Codon-optimised complement factor i

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MX2023004377A (es) 2023-06-28
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CR20230202A (es) 2023-06-13
KR20230088630A (ko) 2023-06-20
EP4229076A1 (en) 2023-08-23
JOP20230076A1 (ar) 2023-04-16
CL2023001072A1 (es) 2023-12-01
WO2022079453A1 (en) 2022-04-21
PH12023551015A1 (en) 2024-02-05
US20230212275A1 (en) 2023-07-06
CN119585299A (zh) 2025-03-07
PE20231747A1 (es) 2023-11-06
CA3182337A1 (en) 2022-04-21
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