JP2023539632A - 操作されたプロテアーゼバリアント - Google Patents

操作されたプロテアーゼバリアント Download PDF

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Publication number
JP2023539632A
JP2023539632A JP2023513730A JP2023513730A JP2023539632A JP 2023539632 A JP2023539632 A JP 2023539632A JP 2023513730 A JP2023513730 A JP 2023513730A JP 2023513730 A JP2023513730 A JP 2023513730A JP 2023539632 A JP2023539632 A JP 2023539632A
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JP
Japan
Prior art keywords
seq
recombinant protease
protease
recombinant
numbered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023513730A
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English (en)
Japanese (ja)
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JP2023539632A5 (https=
Inventor
チンピン チェン，
ニッキ デラス，
ラヴィ デイビッド ガルシア，
イスマイリ， ムーレイ ヒシャム アラウイ
クリステン ジーン ヴァリュウ，
ケリン マクラスキー，
Original Assignee
コデクシス， インコーポレイテッド
ソシエテ デ プロデュイ ネスレ エス．アー．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by コデクシス， インコーポレイテッド, ソシエテ デ プロデュイ ネスレ エス．アー． filed Critical コデクシス， インコーポレイテッド
Publication of JP2023539632A publication Critical patent/JP2023539632A/ja
Publication of JP2023539632A5 publication Critical patent/JP2023539632A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6408—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2023513730A 2020-08-28 2021-08-27 操作されたプロテアーゼバリアント Pending JP2023539632A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063071625P 2020-08-28 2020-08-28
US63/071,625 2020-08-28
PCT/US2021/048105 WO2022047262A1 (en) 2020-08-28 2021-08-27 Engineered protease variants

Publications (2)

Publication Number Publication Date
JP2023539632A true JP2023539632A (ja) 2023-09-15
JP2023539632A5 JP2023539632A5 (https=) 2024-09-03

Family

ID=80354111

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023513730A Pending JP2023539632A (ja) 2020-08-28 2021-08-27 操作されたプロテアーゼバリアント

Country Status (8)

Country Link
US (1) US11959108B2 (https=)
EP (1) EP4204554A4 (https=)
JP (1) JP2023539632A (https=)
CN (1) CN117098847A (https=)
AU (1) AU2021334371A1 (https=)
BR (1) BR112023003606A2 (https=)
CA (1) CA3191867A1 (https=)
WO (1) WO2022047262A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119654410A (zh) * 2022-08-08 2025-03-18 沃特世科技公司 具有增强的自溶抗性的工程化蛋白酶
CN116334020B (zh) * 2023-02-28 2025-11-11 南京工业大学 一种6'-唾液酸转移酶突变体及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015177797A (ja) * 2008-11-11 2015-10-08 ザ プロクター アンド ギャンブルカンパニー セリンプロテアーゼ変異体を含む組成物及び方法

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Also Published As

Publication number Publication date
CA3191867A1 (en) 2022-03-03
EP4204554A4 (en) 2024-08-21
US20220090039A1 (en) 2022-03-24
US11959108B2 (en) 2024-04-16
CN117098847A (zh) 2023-11-21
AU2021334371A1 (en) 2023-03-09
WO2022047262A1 (en) 2022-03-03
EP4204554A1 (en) 2023-07-05
BR112023003606A2 (pt) 2023-03-28

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