JP2023538871A - エキセンジン－４ペプチド類似体 - Google Patents

エキセンジン－４ペプチド類似体 Download PDF

Info

Publication number
JP2023538871A
JP2023538871A JP2023510345A JP2023510345A JP2023538871A JP 2023538871 A JP2023538871 A JP 2023538871A JP 2023510345 A JP2023510345 A JP 2023510345A JP 2023510345 A JP2023510345 A JP 2023510345A JP 2023538871 A JP2023538871 A JP 2023538871A
Authority
JP
Japan
Prior art keywords
lys
amino acid
aaa
exendin
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023510345A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2022034062A5 (https=
JP2023538871A5 (https=
Inventor
ジョナッセン，トーマス，エンゲルブレヒト，ノードキルド
ボーセン，トーマス
Original Assignee
ティーエックスピー ファーマ エージー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ティーエックスピー ファーマ エージー filed Critical ティーエックスピー ファーマ エージー
Publication of JP2023538871A publication Critical patent/JP2023538871A/ja
Publication of JPWO2022034062A5 publication Critical patent/JPWO2022034062A5/ja
Publication of JP2023538871A5 publication Critical patent/JP2023538871A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2023510345A 2020-08-12 2021-08-10 エキセンジン－４ペプチド類似体 Pending JP2023538871A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA202070526 2020-08-12
DKPA202070526 2020-08-12
PCT/EP2021/072251 WO2022034062A1 (en) 2020-08-12 2021-08-10 Exendin-4 peptide analogues

Publications (3)

Publication Number Publication Date
JP2023538871A true JP2023538871A (ja) 2023-09-12
JPWO2022034062A5 JPWO2022034062A5 (https=) 2024-08-19
JP2023538871A5 JP2023538871A5 (https=) 2024-08-19

Family

ID=80246995

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023510345A Pending JP2023538871A (ja) 2020-08-12 2021-08-10 エキセンジン－４ペプチド類似体

Country Status (8)

Country Link
US (1) US20230303640A1 (https=)
EP (1) EP4196495A1 (https=)
JP (1) JP2023538871A (https=)
CN (1) CN116390938A (https=)
AU (1) AU2021324066A1 (https=)
BR (1) BR112023002608A2 (https=)
CA (1) CA3190959A1 (https=)
WO (1) WO2022034062A1 (https=)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006515267A (ja) * 2002-07-04 2006-05-25 ジーランド ファーマ アクティーゼルスカブ Ｇｌｐ−１および糖尿病の処置方法
JP2007001987A (ja) * 1999-07-12 2007-01-11 Zealand Pharma As 血糖値を降下させるペプチド
JP2011503152A (ja) * 2007-11-16 2011-01-27 ノボ・ノルデイスク・エー／エス インスリン及びインスリン分泌性ペプチドを含む薬学的組成物
JP2014521594A (ja) * 2011-05-25 2014-08-28 アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー 長持続期間デュアルホルモンコンジュゲート
JP2017513875A (ja) * 2014-04-22 2017-06-01 ティーエックスピー ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング 分枝状アミノ酸プローブを有するペプチド類似体
JP2019536796A (ja) * 2016-12-02 2019-12-19 サノフイＳａｎｏｆｉ ペプチド三重（ｔｒｉｇｏｎａｌ）ＧＬＰ１／グルカゴン／ＧＩＰ受容体アゴニストとしての新しい化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4356108A (en) 1979-12-20 1982-10-26 The Mead Corporation Encapsulation process
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
JP4394279B2 (ja) 1998-03-09 2010-01-06 ジーランド ファーマ アクティーゼルスカブ 酵素加水分解に対する傾向が減少した薬理学的に活性なペプチド複合体
US6528486B1 (en) * 1999-07-12 2003-03-04 Zealand Pharma A/S Peptide agonists of GLP-1 activity
EP1919947B1 (en) 2005-08-26 2013-02-27 AbbVie Inc. Therapeutically active alpha-msh analogues
US9217023B2 (en) 2012-10-19 2015-12-22 Txp Pharma Gmbh Alpha- and gamma-MSH analogues
HK1211232A1 (en) * 2012-12-21 2016-05-20 Sanofi Exendin-4 derivatives as dual glp1/gip or trigonal glp1/gip/glucagon agonists

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007001987A (ja) * 1999-07-12 2007-01-11 Zealand Pharma As 血糖値を降下させるペプチド
JP2006515267A (ja) * 2002-07-04 2006-05-25 ジーランド ファーマ アクティーゼルスカブ Ｇｌｐ−１および糖尿病の処置方法
JP2011503152A (ja) * 2007-11-16 2011-01-27 ノボ・ノルデイスク・エー／エス インスリン及びインスリン分泌性ペプチドを含む薬学的組成物
JP2014521594A (ja) * 2011-05-25 2014-08-28 アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー 長持続期間デュアルホルモンコンジュゲート
JP2017513875A (ja) * 2014-04-22 2017-06-01 ティーエックスピー ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング 分枝状アミノ酸プローブを有するペプチド類似体
JP2019536796A (ja) * 2016-12-02 2019-12-19 サノフイＳａｎｏｆｉ ペプチド三重（ｔｒｉｇｏｎａｌ）ＧＬＰ１／グルカゴン／ＧＩＰ受容体アゴニストとしての新しい化合物

Also Published As

Publication number Publication date
CA3190959A1 (en) 2022-02-17
AU2021324066A1 (en) 2023-03-30
BR112023002608A2 (pt) 2023-05-09
WO2022034062A1 (en) 2022-02-17
US20230303640A1 (en) 2023-09-28
EP4196495A1 (en) 2023-06-21
CN116390938A (zh) 2023-07-04
AU2021324066A9 (en) 2023-04-27

Similar Documents

Publication Publication Date Title
US8642540B2 (en) Glucagon analogues
US8685919B2 (en) Glucagon analogues
AU2008365559B2 (en) Glucagon analogues
US8642541B2 (en) Glucagon analogues
CA2858949A1 (en) Glucagon analogues
JP2023538871A (ja) エキセンジン－４ペプチド類似体
OA16931A (en) Glucagon analogues.

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230529

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240808

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240808

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20250716

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250722

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20250924

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20260121

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20260407