JP2023538871A - エキセンジン－４ペプチド類似体 - Google Patents

エキセンジン－４ペプチド類似体 Download PDF

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Publication number
JP2023538871A
JP2023538871A JP2023510345A JP2023510345A JP2023538871A JP 2023538871 A JP2023538871 A JP 2023538871A JP 2023510345 A JP2023510345 A JP 2023510345A JP 2023510345 A JP2023510345 A JP 2023510345A JP 2023538871 A JP2023538871 A JP 2023538871A
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JP
Japan
Prior art keywords
lys
amino acid
aaa
exendin
peptide
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JP2023510345A
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English (en)
Japanese (ja)
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JP2023538871A5 (enExample
Inventor
ジョナッセン，トーマス，エンゲルブレヒト，ノードキルド
ボーセン，トーマス
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ティーエックスピー ファーマ エージー
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Publication of JP2023538871A publication Critical patent/JP2023538871A/ja
Publication of JP2023538871A5 publication Critical patent/JP2023538871A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2023510345A 2020-08-12 2021-08-10 エキセンジン－４ペプチド類似体 Pending JP2023538871A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA202070526 2020-08-12
DKPA202070526 2020-08-12
PCT/EP2021/072251 WO2022034062A1 (en) 2020-08-12 2021-08-10 Exendin-4 peptide analogues

Publications (2)

Publication Number Publication Date
JP2023538871A true JP2023538871A (ja) 2023-09-12
JP2023538871A5 JP2023538871A5 (enExample) 2024-08-19

Family

ID=80246995

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023510345A Pending JP2023538871A (ja) 2020-08-12 2021-08-10 エキセンジン－４ペプチド類似体

Country Status (8)

Country Link
US (1) US20230303640A1 (enExample)
EP (1) EP4196495A1 (enExample)
JP (1) JP2023538871A (enExample)
CN (1) CN116390938A (enExample)
AU (1) AU2021324066A1 (enExample)
BR (1) BR112023002608A2 (enExample)
CA (1) CA3190959A1 (enExample)
WO (1) WO2022034062A1 (enExample)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006515267A (ja) * 2002-07-04 2006-05-25 ジーランド ファーマ アクティーゼルスカブ Ｇｌｐ−１および糖尿病の処置方法
JP2007001987A (ja) * 1999-07-12 2007-01-11 Zealand Pharma As 血糖値を降下させるペプチド
JP2011503152A (ja) * 2007-11-16 2011-01-27 ノボ・ノルデイスク・エー／エス インスリン及びインスリン分泌性ペプチドを含む薬学的組成物
JP2014521594A (ja) * 2011-05-25 2014-08-28 アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー 長持続期間デュアルホルモンコンジュゲート
JP2017513875A (ja) * 2014-04-22 2017-06-01 ティーエックスピー ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング 分枝状アミノ酸プローブを有するペプチド類似体
JP2019536796A (ja) * 2016-12-02 2019-12-19 サノフイＳａｎｏｆｉ ペプチド三重（ｔｒｉｇｏｎａｌ）ＧＬＰ１／グルカゴン／ＧＩＰ受容体アゴニストとしての新しい化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4356108A (en) 1979-12-20 1982-10-26 The Mead Corporation Encapsulation process
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
AU757658B2 (en) 1998-03-09 2003-02-27 Zealand Pharma A/S Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
US6528486B1 (en) * 1999-07-12 2003-03-04 Zealand Pharma A/S Peptide agonists of GLP-1 activity
ES2407107T3 (es) 2005-08-26 2013-06-11 Abbvie Inc. Análogos de alfa-MSH terapéuticamente activos
WO2014060606A1 (en) 2012-10-19 2014-04-24 Txp Pharma Gmbh Alpha- and gamma-msh analogues
HUE035803T2 (en) * 2012-12-21 2018-05-28 Sanofi Sa Dual GLP1 / GIP or trigonal GLP1 / GIP / glucagon agonists

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007001987A (ja) * 1999-07-12 2007-01-11 Zealand Pharma As 血糖値を降下させるペプチド
JP2006515267A (ja) * 2002-07-04 2006-05-25 ジーランド ファーマ アクティーゼルスカブ Ｇｌｐ−１および糖尿病の処置方法
JP2011503152A (ja) * 2007-11-16 2011-01-27 ノボ・ノルデイスク・エー／エス インスリン及びインスリン分泌性ペプチドを含む薬学的組成物
JP2014521594A (ja) * 2011-05-25 2014-08-28 アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー 長持続期間デュアルホルモンコンジュゲート
JP2017513875A (ja) * 2014-04-22 2017-06-01 ティーエックスピー ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング 分枝状アミノ酸プローブを有するペプチド類似体
JP2019536796A (ja) * 2016-12-02 2019-12-19 サノフイＳａｎｏｆｉ ペプチド三重（ｔｒｉｇｏｎａｌ）ＧＬＰ１／グルカゴン／ＧＩＰ受容体アゴニストとしての新しい化合物

Also Published As

Publication number Publication date
AU2021324066A9 (en) 2023-04-27
WO2022034062A1 (en) 2022-02-17
US20230303640A1 (en) 2023-09-28
AU2021324066A1 (en) 2023-03-30
BR112023002608A2 (pt) 2023-05-09
CA3190959A1 (en) 2022-02-17
EP4196495A1 (en) 2023-06-21
CN116390938A (zh) 2023-07-04

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