JP2023537632A - 疼痛の処置のためのＮａＶ１．７の非水和ケトン阻害剤 - Google Patents

疼痛の処置のためのＮａＶ１．７の非水和ケトン阻害剤 Download PDF

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JP2023537632A
JP2023537632A JP2023511616A JP2023511616A JP2023537632A JP 2023537632 A JP2023537632 A JP 2023537632A JP 2023511616 A JP2023511616 A JP 2023511616A JP 2023511616 A JP2023511616 A JP 2023511616A JP 2023537632 A JP2023537632 A JP 2023537632A
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alkyl
halo
groups
optionally substituted
compound
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JP2023537632A5 (https=
Inventor
パジョウヘシュ，ハッサン
ムルカイ，ジョン
モンテレオーネ，デニス
チョウ，シャン
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サイトワン セラピューティクス インコーポレイテッド
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Publication of JP2023537632A publication Critical patent/JP2023537632A/ja
Publication of JP2023537632A5 publication Critical patent/JP2023537632A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2023511616A 2020-08-14 2021-08-14 疼痛の処置のためのＮａＶ１．７の非水和ケトン阻害剤 Pending JP2023537632A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063066012P 2020-08-14 2020-08-14
US63/066,012 2020-08-14
PCT/US2021/046054 WO2022036297A1 (en) 2020-08-14 2021-08-14 Non-hydrated ketone inhibitors of nav1.7 for the treatment of pain

Publications (2)

Publication Number Publication Date
JP2023537632A true JP2023537632A (ja) 2023-09-04
JP2023537632A5 JP2023537632A5 (https=) 2024-09-02

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ID=77693595

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JP2023511616A Pending JP2023537632A (ja) 2020-08-14 2021-08-14 疼痛の処置のためのＮａＶ１．７の非水和ケトン阻害剤

Country Status (12)

Country Link
US (1) US20230339958A1 (https=)
EP (2) EP4196482B1 (https=)
JP (1) JP2023537632A (https=)
KR (1) KR20230051252A (https=)
CN (1) CN116368139A (https=)
AU (1) AU2021326546A1 (https=)
BR (1) BR112023002659A2 (https=)
CA (1) CA3188924A1 (https=)
ES (1) ES3061196T3 (https=)
IL (1) IL300626A (https=)
MX (1) MX2023001741A (https=)
WO (1) WO2022036297A1 (https=)

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CN110831945B (zh) 2017-03-29 2023-08-08 赛特温治疗公司 用于治疗疼痛的11,13-修饰的石房蛤毒素类化合物
EP3860714B1 (en) 2018-10-03 2023-09-06 Siteone Therapeutics, Inc. 11,13-modified saxitoxins for the treatment of pain
WO2022256842A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels
CA3221938A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran analogs as modulators of sodium channels
AU2022283934A1 (en) 2021-06-04 2023-11-30 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels
SMT202500481T1 (it) 2021-06-04 2026-01-12 Vertex Pharma N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio
US20240400544A1 (en) 2021-06-04 2024-12-05 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels
HRP20260068T1 (hr) 2021-06-04 2026-02-27 Vertex Pharmaceuticals Incorporated Čvrsti farmaceutski oblici i režimi doziranja koji obuhvaćaju (2r,3s,4s,5r)-4-[[3-(3,4-difluor-2-metoksifenil)-4,5-dimetil-5-(trifluormetil)tetrahidrofuran-2-karbonil]amino]piridin-2-karboksamid
US20230382910A1 (en) 2022-04-22 2023-11-30 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2023205463A1 (en) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
CA3257285A1 (en) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated HETEROARYL COMPOUNDS FOR PAIN RELIEF
CA3256248A1 (en) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated HETEROARYL COMPOUNDS FOR PAIN RELIEF
WO2024123815A1 (en) 2022-12-06 2024-06-13 Vertex Pharmaceuticals Incorporated Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
WO2025090511A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Methods of preparing modulators of sodium channels and solid forms of the same for treating pain
WO2025090480A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2025090516A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Methods of preparing compounds for treating pain and solid forms thereof
WO2025090465A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
US20250186419A1 (en) 2023-12-07 2025-06-12 Vertex Pharmaceuticals Incorporated Dosing regimens for treating pain
US20260001877A1 (en) 2024-06-28 2026-01-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2026013449A2 (en) 2024-07-11 2026-01-15 Sea4Us - Biotecnologia E Recursos Marinhos, Sa Oxazolidone-derived compounds and their use in the treatment of chronic and acute pain
WO2026030525A1 (en) 2024-07-31 2026-02-05 Vertex Pharmaceuticals Incorporated Zilvetrigine dosage forms and dosing regimens for treating pain

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JP2013519653A (ja) * 2010-02-10 2013-05-30 ファイトトックス リミテッド サキシトキシン誘導体での触覚の喪失の処置
WO2018183782A1 (en) * 2017-03-29 2018-10-04 Siteone Therapeutics, Inc. 11,13-modified saxitoxins for the treatment of pain
JP2018534270A (ja) * 2015-09-30 2018-11-22 サイトワン セラピューティクス， インコーポレイテッド 疼痛の治療のための１１，１３−修飾サキシトキシン
WO2020072835A1 (en) * 2018-10-03 2020-04-09 Siteone Therapeutics, Inc. 11,13-modified saxitoxins for the treatment of pain

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JP2012526147A (ja) * 2009-05-07 2012-10-25 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 疼痛の研究、画像化および治療方法、ならびに疼痛の研究、画像化および治療のための組成物
JP2013519653A (ja) * 2010-02-10 2013-05-30 ファイトトックス リミテッド サキシトキシン誘導体での触覚の喪失の処置
JP2018534270A (ja) * 2015-09-30 2018-11-22 サイトワン セラピューティクス， インコーポレイテッド 疼痛の治療のための１１，１３−修飾サキシトキシン
WO2018183782A1 (en) * 2017-03-29 2018-10-04 Siteone Therapeutics, Inc. 11,13-modified saxitoxins for the treatment of pain
WO2020072835A1 (en) * 2018-10-03 2020-04-09 Siteone Therapeutics, Inc. 11,13-modified saxitoxins for the treatment of pain

Also Published As

Publication number Publication date
MX2023001741A (es) 2023-04-25
BR112023002659A2 (pt) 2023-05-02
KR20230051252A (ko) 2023-04-17
EP4196482B1 (en) 2025-10-01
CA3188924A1 (en) 2022-02-17
EP4647075A2 (en) 2025-11-12
EP4647075A3 (en) 2026-01-14
AU2021326546A1 (en) 2023-04-13
WO2022036297A1 (en) 2022-02-17
IL300626A (en) 2023-04-01
ES3061196T3 (en) 2026-03-31
CN116368139A (zh) 2023-06-30
EP4196482A1 (en) 2023-06-21
US20230339958A1 (en) 2023-10-26

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