JP2023537603A - 線条体ニューロンにおける遺伝子発現の調節のための人工発現構築物 - Google Patents

線条体ニューロンにおける遺伝子発現の調節のための人工発現構築物 Download PDF

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JP2023537603A
JP2023537603A JP2023510354A JP2023510354A JP2023537603A JP 2023537603 A JP2023537603 A JP 2023537603A JP 2023510354 A JP2023510354 A JP 2023510354A JP 2023510354 A JP2023510354 A JP 2023510354A JP 2023537603 A JP2023537603 A JP 2023537603A
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seq
ehgt
wpre3
bghpa
gene encoding
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デイグル，ターニャ
レイン，エドワード・セバスチャン
リーバイ，ボアズ・ピー
ミッチ，ジョン・ケイ
タシッチ，ボシリカ
ティン，ジョナサン
ゼン，ホンクイ
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アレン インスティテュート
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/14144—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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  • Bioinformatics & Cheminformatics (AREA)
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  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2023510354A 2020-08-14 2021-08-13 線条体ニューロンにおける遺伝子発現の調節のための人工発現構築物 Pending JP2023537603A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063066008P 2020-08-14 2020-08-14
US63/066,008 2020-08-14
PCT/US2021/045995 WO2022036255A1 (en) 2020-08-14 2021-08-13 Artificial expression constructs for modulating gene expression in striatal neurons

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JP2023537603A true JP2023537603A (ja) 2023-09-04
JP2023537603A5 JP2023537603A5 (https=) 2024-08-21

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US (1) US20230302158A1 (https=)
EP (1) EP4196583A4 (https=)
JP (1) JP2023537603A (https=)
AU (1) AU2021324975A1 (https=)
CA (1) CA3186367A1 (https=)
WO (1) WO2022036255A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250302918A1 (en) * 2022-05-20 2025-10-02 President And Fellows Of Harvard College Methods and compositions relating to treatment of cns diseases
WO2025059552A1 (en) * 2023-09-14 2025-03-20 Allen Institute Artificial expression constructs for modulating gene expression in the basal ganglia
WO2025137554A1 (en) * 2023-12-22 2025-06-26 Allen Institute Artificial expression constructs for modulating gene expression in serotonergic neurons

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010022241A (ja) * 2008-07-16 2010-02-04 Institute Of Physical & Chemical Research Ｍｅｉｓ２遺伝子のエンハンサー
WO2013155222A2 (en) * 2012-04-10 2013-10-17 The Regents Of The University Of California Brain-specific enhancers for cell-based therapy
WO2016161124A1 (en) * 2015-03-31 2016-10-06 New York University Compositions and method for reducing seizures
WO2020076614A1 (en) * 2018-10-08 2020-04-16 Allen Institute Artificial expression constructs for selectively modulating gene expression in interneurons
WO2020097121A1 (en) * 2018-11-05 2020-05-14 Allen Institute Artificial expression constructs for selectively modulating gene expression in excitatory cortical neurons

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005054467A1 (ja) * 2003-12-03 2005-06-16 Chugai Seiyaku Kabushiki Kaisha 哺乳類βアクチンプロモーターを利用した発現系
CA2680060A1 (en) * 2007-03-07 2008-09-12 Nventa Biopharmaceuticals Corporation Double-stranded locked nucleic acid compositions
US9790490B2 (en) * 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010022241A (ja) * 2008-07-16 2010-02-04 Institute Of Physical & Chemical Research Ｍｅｉｓ２遺伝子のエンハンサー
WO2013155222A2 (en) * 2012-04-10 2013-10-17 The Regents Of The University Of California Brain-specific enhancers for cell-based therapy
WO2016161124A1 (en) * 2015-03-31 2016-10-06 New York University Compositions and method for reducing seizures
WO2020076614A1 (en) * 2018-10-08 2020-04-16 Allen Institute Artificial expression constructs for selectively modulating gene expression in interneurons
WO2020097121A1 (en) * 2018-11-05 2020-05-14 Allen Institute Artificial expression constructs for selectively modulating gene expression in excitatory cortical neurons

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WO2022036255A1 (en) 2022-02-17
US20230302158A1 (en) 2023-09-28
EP4196583A4 (en) 2025-07-09
EP4196583A1 (en) 2023-06-21
AU2021324975A1 (en) 2023-03-16
CA3186367A1 (en) 2022-02-17

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