JP2023537229A - SARS-CoV-2タンパク質と宿主細胞の分子機構および細胞機構との相互作用、およびCOVID-19を処置するための製剤 - Google Patents

SARS-CoV-2タンパク質と宿主細胞の分子機構および細胞機構との相互作用、およびCOVID-19を処置するための製剤 Download PDF

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JP2023537229A
JP2023537229A JP2023503508A JP2023503508A JP2023537229A JP 2023537229 A JP2023537229 A JP 2023537229A JP 2023503508 A JP2023503508 A JP 2023503508A JP 2023503508 A JP2023503508 A JP 2023503508A JP 2023537229 A JP2023537229 A JP 2023537229A
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cells
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protein
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JP2023537229A5 (https=
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マーチャント,シュリーマ
パテル,マニット
エレーヌ ダンカン,ロビン
フェルナンダ デ アンドラーデ フェルナンデス,マリア
アナント ジャダブ,ビシャル
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Akseera Pharma Corp
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JP2023503508A 2020-07-18 2021-07-19 SARS-CoV-2タンパク質と宿主細胞の分子機構および細胞機構との相互作用、およびCOVID-19を処置するための製剤 Pending JP2023537229A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
IN202021030633 2020-07-18
IN202021030633 2020-07-18
IN202021054151 2020-12-12
IN202021054151 2020-12-12
PCT/IN2021/050325 WO2021199078A2 (en) 2020-03-29 2021-03-30 Interaction of sars-cov-2 proteins with molecular and cellular mechanisms of host cells and formulations to treat covid-19.
INPCT/IN2021/050325 2021-03-30
PCT/IN2021/050699 WO2022018754A1 (en) 2020-07-18 2021-07-19 Interaction of sars-cov-2 proteins with molecular and cellular mechanisms of host cells and formulations to treat covid-19.

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JP2023537229A true JP2023537229A (ja) 2023-08-31
JP2023537229A5 JP2023537229A5 (https=) 2024-07-26

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US (1) US20240024337A1 (https=)
EP (1) EP4181917A4 (https=)
JP (1) JP2023537229A (https=)
AU (1) AU2021313476A1 (https=)
CA (2) CA3179022A1 (https=)
IL (1) IL300014A (https=)
WO (1) WO2022018754A1 (https=)

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EP4126913A4 (en) * 2020-03-29 2024-09-18 Akseera Pharma Corp. INTERACTION OF SARS-COV-2 PROTEINS WITH MOLECULAR AND CELLULAR MECHANISMS OF HOST CELLS AND FORMULATIONS FOR THE TREATMENT OF COVID-19
AU2022204290A1 (en) * 2020-12-12 2023-07-27 Akseera Pharma Corp. Cannabidiol for augmenting vaccine mediated immunity and prophylaxis of covid-19
CA3255538A1 (en) * 2022-04-07 2023-10-12 Shreema DR. MERCHANT METHOD FOR USING CANNABIDIOL IN THE PREVENTION AND TREATMENT OF INTERFERON-SENSITIVE CONDITIONS

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN111686095A (zh) * 2020-07-24 2020-09-22 中国人民解放军军事科学院军事医学研究院 大麻二酚在制备治疗冠状病毒感染的药物中的用途

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JP2012520684A (ja) * 2009-03-19 2012-09-10 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸(siNA)を用いたBTBandCNCHomology1(塩基性ロイシンジッパー転写因子1)(Bach1)遺伝子発現のRNA干渉媒介性阻害
EP4126913A4 (en) * 2020-03-29 2024-09-18 Akseera Pharma Corp. INTERACTION OF SARS-COV-2 PROTEINS WITH MOLECULAR AND CELLULAR MECHANISMS OF HOST CELLS AND FORMULATIONS FOR THE TREATMENT OF COVID-19
WO2021209998A1 (en) * 2020-04-14 2021-10-21 Molad Ami Composition for the treatment of respiratory symptoms and methods thereof
US20230181484A1 (en) * 2020-05-11 2023-06-15 Add Advanced Drug Delivery Technologies Ltd. Uses and Formulations of Cannabinoids
US20230338396A1 (en) * 2020-05-14 2023-10-26 Augusta University Research Institute, Inc. Cannabidiol as a therapeutic modality for covid-19

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Publication number Priority date Publication date Assignee Title
CN111686095A (zh) * 2020-07-24 2020-09-22 中国人民解放军军事科学院军事医学研究院 大麻二酚在制备治疗冠状病毒感染的药物中的用途

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANIL, SEEGEHALLI M. ET AL.: "Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in l", SCIENTIFIC REPORTS, vol. 11(1), JPN6025031793, 14 January 2021 (2021-01-14), pages 1462, ISSN: 0005781477 *
BIORXIV [PREPRINT], JPN6025017903, 10 March 2021 (2021-03-10), pages 1 - 15, ISSN: 0005781474 *
BRITISH JOURNAL OF PHARMACOLOGY, vol. 177, JPN6025017908, 16 July 2020 (2020-07-16), pages 4967 - 4970, ISSN: 0005781476 *
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, vol. 168, JPN6025017905, 5 December 2020 (2020-12-05), pages 474 - 485, ISSN: 0005781475 *

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US20240024337A1 (en) 2024-01-25
EP4181917A1 (en) 2023-05-24
CA3189802A1 (en) 2022-01-27
CA3179022A1 (en) 2021-10-07
EP4181917A4 (en) 2024-10-30
IL300014A (en) 2023-03-01
WO2022018754A1 (en) 2022-01-27
AU2021313476A1 (en) 2023-03-16

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