JP2023533693A - ＧａｌＮＡｃ－オリゴヌクレオチドコンジュゲート及びサポニンの治療用配合物、及びその使用 - Google Patents

ＧａｌＮＡｃ－オリゴヌクレオチドコンジュゲート及びサポニンの治療用配合物、及びその使用 Download PDF

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JP2023533693A
JP2023533693A JP2022580238A JP2022580238A JP2023533693A JP 2023533693 A JP2023533693 A JP 2023533693A JP 2022580238 A JP2022580238 A JP 2022580238A JP 2022580238 A JP2022580238 A JP 2022580238A JP 2023533693 A JP2023533693 A JP 2023533693A
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Prior art keywords
xyl
rha
saponin
fuc
group
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JP2022580238A
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Japanese (ja)
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JP2023533693A5 (https=
Inventor
ポステル，ルーベン
ヘアマンス，ガイ
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Sapreme Technologies BV
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Sapreme Technologies BV
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Priority claimed from PCT/NL2021/050384 external-priority patent/WO2021261992A1/en
Application filed by Sapreme Technologies BV filed Critical Sapreme Technologies BV
Publication of JP2023533693A publication Critical patent/JP2023533693A/ja
Publication of JP2023533693A5 publication Critical patent/JP2023533693A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2022580238A 2020-06-24 2021-06-23 ＧａｌＮＡｃ－オリゴヌクレオチドコンジュゲート及びサポニンの治療用配合物、及びその使用 Pending JP2023533693A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NL2025902 2020-06-24
NL2025902 2020-06-24
PCT/NL2021/050384 WO2021261992A1 (en) 2020-06-24 2021-06-18 Conjugate of galnac and saponin, therapeutic composition comprising said conjugate and a galnac-oligonucleotide conjugate
NLPCT/NL2021/050384 2021-06-18
PCT/NL2021/050394 WO2021261998A1 (en) 2020-06-24 2021-06-23 Therapeutic combination of galnac-oligonucleotide conjugate and saponin, and uses thereof

Publications (2)

Publication Number Publication Date
JP2023533693A true JP2023533693A (ja) 2023-08-04
JP2023533693A5 JP2023533693A5 (https=) 2024-07-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022580238A Pending JP2023533693A (ja) 2020-06-24 2021-06-23 ＧａｌＮＡｃ－オリゴヌクレオチドコンジュゲート及びサポニンの治療用配合物、及びその使用

Country Status (9)

Country Link
US (1) US20230293562A1 (https=)
EP (2) EP4596052A3 (https=)
JP (1) JP2023533693A (https=)
KR (1) KR20230044196A (https=)
CN (1) CN116194148A (https=)
AU (1) AU2021296983A1 (https=)
CA (1) CA3183881A1 (https=)
IL (1) IL299349A (https=)
WO (1) WO2021261998A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20260025101A (ko) * 2023-06-02 2026-02-23 사프렘 테크놀로지스 비.브이. 세포내 분자 표적을 통해 작용하는 치료적 이펙터 성분을 위한 개선된 치료 요법
WO2025155911A1 (en) 2024-01-18 2025-07-24 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of hurler syndrome

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015071388A1 (en) * 2013-11-14 2015-05-21 Roche Innovation Center Copenhagen A/S Apob antisense conjugate compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011054811A1 (en) * 2009-11-03 2011-05-12 Santaris Pharma A/S Rna antagonists targeting hsp27 combination therapy
SG11202106603UA (en) * 2018-12-21 2021-07-29 Sapreme Tech Bv Biologically active cluster of molecules

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015071388A1 (en) * 2013-11-14 2015-05-21 Roche Innovation Center Copenhagen A/S Apob antisense conjugate compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOMEDICINES, vol. 5, no. 14, JPN6025032636, 2017, pages 1 - 25, ISSN: 0005661356 *
MOLECULAR THERAPY: NUCLEIC ACIDS, vol. 14, JPN6025032638, 2019, pages 67 - 79, ISSN: 0005661357 *

Also Published As

Publication number Publication date
EP4171643C0 (en) 2025-06-04
CN116194148A (zh) 2023-05-30
US20230293562A1 (en) 2023-09-21
WO2021261998A1 (en) 2021-12-30
EP4596052A2 (en) 2025-08-06
EP4596052A3 (en) 2025-11-05
CA3183881A1 (en) 2021-12-30
KR20230044196A (ko) 2023-04-03
EP4171643B1 (en) 2025-06-04
EP4171643A1 (en) 2023-05-03
AU2021296983A1 (en) 2023-02-23
IL299349A (en) 2023-02-01

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