JP2023530489A - Flrt3媒介性シグナル伝達を調節するための組成物及び方法 - Google Patents

Flrt3媒介性シグナル伝達を調節するための組成物及び方法 Download PDF

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JP2023530489A
JP2023530489A JP2022578562A JP2022578562A JP2023530489A JP 2023530489 A JP2023530489 A JP 2023530489A JP 2022578562 A JP2022578562 A JP 2022578562A JP 2022578562 A JP2022578562 A JP 2022578562A JP 2023530489 A JP2023530489 A JP 2023530489A
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flrt3
seq
antibody
chain variable
sequence identity
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JPWO2021258040A5 (fr
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ダラス ベンジャミン フライズ
クシャル プラジャパティ
アデム キャン コクサル
リンダ リュー
ソロモン ランゲルマン
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ネクストキュア インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)
JP2022578562A 2020-06-18 2021-06-21 Flrt3媒介性シグナル伝達を調節するための組成物及び方法 Pending JP2023530489A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063040654P 2020-06-18 2020-06-18
US63/040,654 2020-06-18
PCT/US2021/038201 WO2021258040A2 (fr) 2020-06-18 2021-06-21 Compositions et procédés de modulation de la transduction du signal médiée par flrt3

Publications (2)

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JP2023530489A true JP2023530489A (ja) 2023-07-18
JPWO2021258040A5 JPWO2021258040A5 (fr) 2024-06-27

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JP2022578562A Pending JP2023530489A (ja) 2020-06-18 2021-06-21 Flrt3媒介性シグナル伝達を調節するための組成物及び方法

Country Status (5)

Country Link
JP (1) JP2023530489A (fr)
CN (1) CN116322748A (fr)
AU (1) AU2021293287A1 (fr)
CA (1) CA3183242A1 (fr)
WO (1) WO2021258040A2 (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022952A1 (es) * 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
JP6590284B2 (ja) * 2015-02-13 2019-10-16 国立大学法人大阪大学 疼痛抑制物質のスクリーニング方法および疼痛の予防または治療用医薬組成物
WO2017083515A2 (fr) * 2015-11-10 2017-05-18 Visterra, Inc. Conjugués molécules anticorps-médicaments et leurs utilisations
US10617773B2 (en) * 2016-08-05 2020-04-14 Dana-Farber Cancer Institute, Inc. Antibodies against the MUC1-C/extracellular domain (MUC1-C/ECD)

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Publication number Publication date
CA3183242A1 (fr) 2021-12-23
AU2021293287A1 (en) 2023-02-16
WO2021258040A2 (fr) 2021-12-23
WO2021258040A3 (fr) 2022-01-27
CN116322748A (zh) 2023-06-23

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