JP2023529640A - 治療用コンジュゲート - Google Patents

治療用コンジュゲート Download PDF

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Publication number
JP2023529640A
JP2023529640A JP2022574600A JP2022574600A JP2023529640A JP 2023529640 A JP2023529640 A JP 2023529640A JP 2022574600 A JP2022574600 A JP 2022574600A JP 2022574600 A JP2022574600 A JP 2022574600A JP 2023529640 A JP2023529640 A JP 2023529640A
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Prior art keywords
conjugate
group
dendrimer
targeting agent
lys
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JP2022574600A
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Japanese (ja)
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JP2023529640A5 (https=
Inventor
ラムナトラオ シェングル，スディール
オーウェン，デビッド
ハフトン，リチャード
テュレヒト，クリス
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スターファーマ ピーティーワイ エルティーディー
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Priority claimed from AU2020901833A external-priority patent/AU2020901833A0/en
Application filed by スターファーマ ピーティーワイ エルティーディー filed Critical スターファーマ ピーティーワイ エルティーディー
Publication of JP2023529640A publication Critical patent/JP2023529640A/ja
Publication of JP2023529640A5 publication Critical patent/JP2023529640A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A61K47/6885—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2022574600A 2020-06-03 2021-06-03 治療用コンジュゲート Pending JP2023529640A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2020901833A AU2020901833A0 (en) 2020-06-03 Therapeutic conjugates
AU2020901833 2020-06-03
PCT/AU2021/050554 WO2021243415A1 (en) 2020-06-03 2021-06-03 Therapeutic conjugates

Publications (2)

Publication Number Publication Date
JP2023529640A true JP2023529640A (ja) 2023-07-11
JP2023529640A5 JP2023529640A5 (https=) 2024-06-10

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JP2022574600A Pending JP2023529640A (ja) 2020-06-03 2021-06-03 治療用コンジュゲート

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US (1) US20240293588A1 (https=)
JP (1) JP2023529640A (https=)
KR (1) KR20230065935A (https=)
CN (1) CN115989039A (https=)
AU (1) AU2021284918A1 (https=)
CA (1) CA3180877A1 (https=)
WO (1) WO2021243415A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180326081A1 (en) * 2011-06-06 2018-11-15 Starpharma Pty Ltd Macromolecules
WO2023244828A1 (en) * 2022-06-17 2023-12-21 Purdue Research Foundation Fibroblast activation protein-targeted nanoparticle magnetic resonance imaging agents
WO2024007034A2 (en) * 2022-07-01 2024-01-04 The Johns Hopkins University Dendrimer-delivered alpha-particle radiotherapy for treatment of glioblastoma and other cancers in the brain
WO2024168199A1 (en) * 2023-02-09 2024-08-15 Regeneron Pharmaceuticals, Inc. Antibody-drug conjugates via inverse electron demand diels-alder reactions
WO2026046228A1 (zh) * 2024-08-27 2026-03-05 苏州拓界医药有限公司 树枝状聚合物偶联物及其制备方法
CN120025408B (zh) * 2025-04-23 2025-08-01 湖南中晟全肽生物科技股份有限公司 一种靶向fgfr2的多肽核素配体、探针及其应用

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