KR20230065935A - 치료적 접합체 - Google Patents
치료적 접합체 Download PDFInfo
- Publication number
- KR20230065935A KR20230065935A KR1020227046150A KR20227046150A KR20230065935A KR 20230065935 A KR20230065935 A KR 20230065935A KR 1020227046150 A KR1020227046150 A KR 1020227046150A KR 20227046150 A KR20227046150 A KR 20227046150A KR 20230065935 A KR20230065935 A KR 20230065935A
- Authority
- KR
- South Korea
- Prior art keywords
- conjugate
- group
- targeting agent
- dendrimer
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
- A61K47/6885—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
- C08G83/002—Dendritic macromolecules
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- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
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- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2020901833A AU2020901833A0 (en) | 2020-06-03 | Therapeutic conjugates | |
| AU2020901833 | 2020-06-03 | ||
| PCT/AU2021/050554 WO2021243415A1 (en) | 2020-06-03 | 2021-06-03 | Therapeutic conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20230065935A true KR20230065935A (ko) | 2023-05-12 |
Family
ID=78831413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227046150A Pending KR20230065935A (ko) | 2020-06-03 | 2021-06-03 | 치료적 접합체 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240293588A1 (https=) |
| JP (1) | JP2023529640A (https=) |
| KR (1) | KR20230065935A (https=) |
| CN (1) | CN115989039A (https=) |
| AU (1) | AU2021284918A1 (https=) |
| CA (1) | CA3180877A1 (https=) |
| WO (1) | WO2021243415A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180326081A1 (en) * | 2011-06-06 | 2018-11-15 | Starpharma Pty Ltd | Macromolecules |
| WO2023244828A1 (en) * | 2022-06-17 | 2023-12-21 | Purdue Research Foundation | Fibroblast activation protein-targeted nanoparticle magnetic resonance imaging agents |
| WO2024007034A2 (en) * | 2022-07-01 | 2024-01-04 | The Johns Hopkins University | Dendrimer-delivered alpha-particle radiotherapy for treatment of glioblastoma and other cancers in the brain |
| WO2024168199A1 (en) * | 2023-02-09 | 2024-08-15 | Regeneron Pharmaceuticals, Inc. | Antibody-drug conjugates via inverse electron demand diels-alder reactions |
| WO2026046228A1 (zh) * | 2024-08-27 | 2026-03-05 | 苏州拓界医药有限公司 | 树枝状聚合物偶联物及其制备方法 |
| CN120025408B (zh) * | 2025-04-23 | 2025-08-01 | 湖南中晟全肽生物科技股份有限公司 | 一种靶向fgfr2的多肽核素配体、探针及其应用 |
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| WO2009127691A1 (en) * | 2008-04-17 | 2009-10-22 | Ablynx N.V. | Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same |
| CA2770980A1 (en) * | 2009-07-15 | 2011-01-20 | Roger Y. Tsien | Peptides whose uptake in cells is controllable |
| IN2014DN00101A (https=) * | 2011-06-06 | 2015-05-15 | Starpharma Pty Ltd | |
| US20160106856A1 (en) * | 2012-08-14 | 2016-04-21 | Angiochem Inc. | Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin |
| US9642916B2 (en) * | 2012-12-12 | 2017-05-09 | The Regents Of The University Of California | Porphyrin modified telodendrimers |
| US10550201B2 (en) * | 2013-03-13 | 2020-02-04 | Bioventures, Llc | Antibody-nanoparticle conjugates for the treatment of drug abuse |
| US10898594B2 (en) * | 2015-10-27 | 2021-01-26 | The Johns Hopkins University | PAMAM dendrimer based CEST imaging agents and uses thereof |
| JP7541978B2 (ja) * | 2018-11-29 | 2024-08-29 | スターファーマ ピーティーワイ エルティーディー | 治療および画像化のためのデンドリマー |
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- 2021-06-03 WO PCT/AU2021/050554 patent/WO2021243415A1/en not_active Ceased
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| JP2023529640A (ja) | 2023-07-11 |
| US20240293588A1 (en) | 2024-09-05 |
| WO2021243415A1 (en) | 2021-12-09 |
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