JP2023529611A5 - - Google Patents

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Publication number
JP2023529611A5
JP2023529611A5 JP2022574164A JP2022574164A JP2023529611A5 JP 2023529611 A5 JP2023529611 A5 JP 2023529611A5 JP 2022574164 A JP2022574164 A JP 2022574164A JP 2022574164 A JP2022574164 A JP 2022574164A JP 2023529611 A5 JP2023529611 A5 JP 2023529611A5
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JP
Japan
Prior art keywords
domain
fusion protein
nuclease
terminus
sequence number
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022574164A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023529611A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/035244 external-priority patent/WO2021247570A2/en
Publication of JP2023529611A publication Critical patent/JP2023529611A/ja
Publication of JP2023529611A5 publication Critical patent/JP2023529611A5/ja
Pending legal-status Critical Current

Links

JP2022574164A 2020-06-02 2021-06-01 ゲノム編集のための組成物及び方法 Pending JP2023529611A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063033397P 2020-06-02 2020-06-02
US63/033,397 2020-06-02
US202063114850P 2020-11-17 2020-11-17
US63/114,850 2020-11-17
US202163171698P 2021-04-07 2021-04-07
US63/171,698 2021-04-07
PCT/US2021/035244 WO2021247570A2 (en) 2020-06-02 2021-06-01 Compositions and methods for gene editing

Publications (2)

Publication Number Publication Date
JP2023529611A JP2023529611A (ja) 2023-07-11
JP2023529611A5 true JP2023529611A5 (https=) 2024-06-10

Family

ID=78831704

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022574164A Pending JP2023529611A (ja) 2020-06-02 2021-06-01 ゲノム編集のための組成物及び方法

Country Status (10)

Country Link
US (1) US20240309345A1 (https=)
EP (1) EP4158009A4 (https=)
JP (1) JP2023529611A (https=)
KR (1) KR20230031832A (https=)
AU (1) AU2021283185A1 (https=)
CA (1) CA3184884A1 (https=)
GB (2) GB2637278B (https=)
IL (1) IL298434A (https=)
MX (1) MX2022015277A (https=)
WO (1) WO2021247570A2 (https=)

Families Citing this family (31)

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Publication number Priority date Publication date Assignee Title
CA3227103A1 (en) 2021-07-30 2023-02-02 Matthew P. GEMBERLING Compositions and methods for modulating expression of frataxin (fxn)
US20240252684A1 (en) 2021-07-30 2024-08-01 Tune Therapeutics, Inc. Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2)
GB2625500B (en) 2021-09-21 2026-04-01 Scribe Therapeutics Inc Engineered CasX repressor systems
IL316722A (en) * 2022-05-01 2024-12-01 Chroma Medicine Inc Compositions and methods for epigenetic regulation of PCSK9 expression
GB2634837A (en) * 2022-06-07 2025-04-23 Scribe Therapeutics Inc Compositions and methods for the targeting of PCSK9
JP2025524455A (ja) * 2022-06-23 2025-07-30 エヌクロマ・バイオ,インコーポレーテッド Trac発現のエピジェネティック調節のための組成物及び方法
IL317701A (en) * 2022-06-23 2025-02-01 Chroma Medicine Inc Epigenetic editing compositions and methods
EP4544058A1 (en) * 2022-06-23 2025-04-30 Chroma Medicine, Inc. Compositions and methods for epigenetic regulation of ciita expression
IL317874A (en) 2022-06-24 2025-02-01 Tune Therapeutics Inc Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression
CA3260110A1 (en) 2022-06-24 2023-12-28 European Molecular Biology Laboratory MODULAR TOOL BASED ON CRISPR FOR THE SPECIFIC INTRODUCTION OF EPIGENETIC MODIFICATIONS ON TARGET LOCI
CA3261865A1 (en) 2022-07-12 2024-01-18 Tune Therapeutics, Inc. TARGETED TRANSCRIPTIONAL ACTIVATION COMPOSITIONS, SYSTEMS AND METHODS
KR20250077608A (ko) * 2022-08-19 2025-05-30 튠 쎄라퓨틱스, 인코포레이티드 표적 유전자 억제를 통한 b형 간염 바이러스 조절용 조성물, 시스템 및 방법
WO2024044574A1 (en) * 2022-08-23 2024-02-29 The Regents Of The University Of California Compositions and methods for reducing ionizing radiation-induced hematopoietic stem cell damage
WO2024064642A2 (en) 2022-09-19 2024-03-28 Tune Therapeutics, Inc. Compositions, systems, and methods for modulating t cell function
IL319704A (en) * 2022-09-23 2025-05-01 Nchroma Bio Inc Compositions and methods for epigenetic regulation of HBV gene expression
WO2024081879A1 (en) * 2022-10-14 2024-04-18 Chroma Medicine, Inc. Compositions and methods for epigenetic regulation of cd247 expression
WO2024163683A2 (en) 2023-02-01 2024-08-08 Tune Therapeutics, Inc. Systems, compositions, and methods for modulating expression of methyl-cpg binding protein 2 (mecp2) and x-inactive specific transcript (xist)
WO2024163678A2 (en) 2023-02-01 2024-08-08 Tune Therapeutics, Inc. Fusion proteins and systems for targeted activation of frataxin (fxn) and related methods
KR20250165443A (ko) 2023-02-17 2025-11-25 화이트헤드 인스티튜트 포 바이오메디칼 리서치 후성유전학적 변형 제조를 위한 조성물 및 방법
WO2024238321A1 (en) * 2023-05-12 2024-11-21 Mammoth Biosciences, Inc. Compositions and methods for targeted epigenetic modification
AU2024270764A1 (en) 2023-05-15 2025-12-04 Nchroma Bio, Inc. Compositions and methods for epigenetic regulation of hbv gene expression
WO2024238700A1 (en) * 2023-05-15 2024-11-21 Chroma Medicine, Inc. Compositions and methods for epigenetic regulation of hbv gene expression
KR20260030105A (ko) * 2023-06-16 2026-03-05 에피제닉 테라퓨틱스 피티이 리미티드 B형 간염 바이러스 유전자를 표적으로 하는 후성유전학적 편집 도구
WO2025029840A1 (en) 2023-07-31 2025-02-06 Tune Therapeutics, Inc. Compositions and methods for multiplexed activation and repression of t cell gene expression
CN121909284A (zh) 2023-07-31 2026-04-21 图恩疗法股份有限公司 用于调节il-2基因表达的组合物和方法
WO2025038494A1 (en) 2023-08-11 2025-02-20 Tune Therapeutics, Inc. Compositions, systems, and methods for lymphoid cell differentiation using targeted gene activation
WO2025059073A1 (en) 2023-09-11 2025-03-20 Tune Therapeutics, Inc. Epigenetic editing methods and systems for differentiating stem cells
WO2025251019A1 (en) * 2024-05-31 2025-12-04 Nchroma Bio, Inc. Compositions and methods for epigenetic editing
WO2025260068A1 (en) 2024-06-14 2025-12-18 Tune Therapeutics, Inc. Lipid nanoparticle formulation for delivery of nucleic acids to cells
WO2026015647A1 (en) 2024-07-09 2026-01-15 Tune Therapeutics, Inc. Compositions, systems, and methods for cell differentiation using targeted gene activation of dll4 and/or vcam1
WO2026064753A1 (en) 2024-09-23 2026-03-26 Tune Therapeutics, Inc. Dna methyltransferase-like protein (dnmt3l) or dna methyltransferase 3a (dnmt3a) repressor systems for epigenetic editing

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10077453B2 (en) * 2014-07-30 2018-09-18 President And Fellows Of Harvard College CAS9 proteins including ligand-dependent inteins
US20190127713A1 (en) * 2016-04-13 2019-05-02 Duke University Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
EP3463484B1 (en) * 2016-05-27 2026-01-07 The Regents of the University of California Methods and compositions for targeting rna polymerases and non-coding rna biogenesis to specific loci
KR102922694B1 (ko) * 2018-04-19 2026-02-03 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 유전자 편집을 위한 조성물 및 방법

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