JP2023529214A5 - - Google Patents
Info
- Publication number
- JP2023529214A5 JP2023529214A5 JP2022575977A JP2022575977A JP2023529214A5 JP 2023529214 A5 JP2023529214 A5 JP 2023529214A5 JP 2022575977 A JP2022575977 A JP 2022575977A JP 2022575977 A JP2022575977 A JP 2022575977A JP 2023529214 A5 JP2023529214 A5 JP 2023529214A5
- Authority
- JP
- Japan
- Prior art keywords
- approximately
- epha2
- cancer
- tumor tissue
- staining assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063038279P | 2020-06-12 | 2020-06-12 | |
| US63/038,279 | 2020-06-12 | ||
| PCT/GB2021/051451 WO2021250418A1 (en) | 2020-06-12 | 2021-06-11 | Treatment of diseases characterized by overexpression of erythropoietin-producing hepatocellular receptor a2 (epha2) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023529214A JP2023529214A (ja) | 2023-07-07 |
| JP2023529214A5 true JP2023529214A5 (https=) | 2024-06-19 |
Family
ID=76641715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022575977A Pending JP2023529214A (ja) | 2020-06-12 | 2021-06-11 | エリスロポエチン産生肝細胞受容体ａ２（ｅｐｈａ２）の過剰発現を特徴とする疾患の治療 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230233698A1 (https=) |
| EP (1) | EP4165414A1 (https=) |
| JP (1) | JP2023529214A (https=) |
| KR (1) | KR20230065231A (https=) |
| CN (1) | CN115698720A (https=) |
| AU (1) | AU2021289095A1 (https=) |
| CA (1) | CA3180095A1 (https=) |
| IL (1) | IL298868A (https=) |
| MX (1) | MX2022015419A (https=) |
| WO (1) | WO2021250418A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107148425B (zh) | 2014-10-29 | 2021-08-03 | 拜斯科阿迪有限公司 | 对mt1-mmp特异性的双环肽配体 |
| EP3645549A1 (en) | 2017-06-26 | 2020-05-06 | BicycleRD Limited | Bicyclic peptide ligands with detectable moieties and uses thereof |
| JP7670481B2 (ja) | 2017-08-04 | 2025-04-30 | バイスクルテクス・リミテッド | Ｃｄ１３７に対して特異的な二環式ペプチドリガンド |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
| CN111902429A (zh) | 2018-02-23 | 2020-11-06 | 拜斯科技术开发有限公司 | 多聚体双环肽配体 |
| IL279489B2 (en) | 2018-06-22 | 2025-10-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate |
| GB201810316D0 (en) | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| WO2020128527A1 (en) | 2018-12-21 | 2020-06-25 | Bicyclerd Limited | Bicyclic peptide ligands specific for pd-l1 |
| US12492224B2 (en) | 2018-12-21 | 2025-12-09 | Bicycletx Limited | Bicyclic peptide ligands specific for PD-L1 |
| GB201900529D0 (en) | 2019-01-15 | 2019-03-06 | Bicycletx Ltd | Bicyclic peptide ligands specific for CD38 |
| WO2020225577A1 (en) | 2019-05-09 | 2020-11-12 | Bicycletx Limited | Bicyclic peptide ligands specific for ox40 |
| TWI860386B (zh) | 2019-07-30 | 2024-11-01 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| AU2021322934A1 (en) | 2020-08-03 | 2023-03-30 | Bicycletx Limited | Peptide-based linkers |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101155830B (zh) * | 2005-02-04 | 2014-06-18 | 雷文生物技术公司 | 结合epha2的抗体及其使用方法 |
| US20100254996A1 (en) * | 2007-06-18 | 2010-10-07 | Medimmune, Llc | Synergistic treatment of cells that express epha2 and erbb2 |
| US20110281279A1 (en) * | 2007-12-21 | 2011-11-17 | Siemens Healthcare Diagnostics Inc. | CIRCULATING Epha2 RECEPTOR |
| EP2653545A1 (en) | 2008-02-05 | 2013-10-23 | Bicycle Therapeutics Limited | Methods and compositions |
| KR20140067052A (ko) * | 2011-09-09 | 2014-06-03 | 암젠 인코퍼레이티드 | 식도암 및 위암 환자들에서 항-간세포 성장 인자（“ｈｇｆ”） 항체들의 유효성을 예측하기 위한 ｃ―ｍｅｔ 단백질의 용도 |
| WO2016171242A1 (ja) * | 2015-04-24 | 2016-10-27 | 第一三共株式会社 | Ｅｐｈａ２の検出 |
| JP2019512477A (ja) * | 2016-03-16 | 2019-05-16 | メリマック ファーマシューティカルズ インコーポレーティッド | エフリン受容体ａ２（ｅｐｈａ２）のナノリポソーム標的化及び関連する診断 |
| GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| CN109700812A (zh) * | 2019-01-18 | 2019-05-03 | 厦门大学 | 一种治疗表达parp10的肝细胞癌的药物组合物及其应用 |
| SG11202110828UA (en) * | 2019-04-02 | 2021-10-28 | Bicycletx Ltd | Bicycle toxin conjugates and uses thereof |
| MX2022006001A (es) * | 2019-11-27 | 2022-10-27 | Bicycletx Ltd | Ligandos de peptidos biciclicos especificos para el receptor 2 tipo a de efrina (epha2) y usos de los mismos. |
-
2021
- 2021-06-11 CN CN202180042177.6A patent/CN115698720A/zh active Pending
- 2021-06-11 AU AU2021289095A patent/AU2021289095A1/en active Pending
- 2021-06-11 WO PCT/GB2021/051451 patent/WO2021250418A1/en not_active Ceased
- 2021-06-11 IL IL298868A patent/IL298868A/en unknown
- 2021-06-11 MX MX2022015419A patent/MX2022015419A/es unknown
- 2021-06-11 US US18/001,374 patent/US20230233698A1/en active Pending
- 2021-06-11 KR KR1020237001004A patent/KR20230065231A/ko active Pending
- 2021-06-11 EP EP21735361.4A patent/EP4165414A1/en active Pending
- 2021-06-11 CA CA3180095A patent/CA3180095A1/en active Pending
- 2021-06-11 JP JP2022575977A patent/JP2023529214A/ja active Pending
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