JP2023528207A - 組換えｃｄ４０結合タンパク質及びそれらの使用 - Google Patents

組換えｃｄ４０結合タンパク質及びそれらの使用 Download PDF

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Publication number
JP2023528207A
JP2023528207A JP2022568692A JP2022568692A JP2023528207A JP 2023528207 A JP2023528207 A JP 2023528207A JP 2022568692 A JP2022568692 A JP 2022568692A JP 2022568692 A JP2022568692 A JP 2022568692A JP 2023528207 A JP2023528207 A JP 2023528207A
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Prior art keywords
seq
ankyrin repeat
amino acid
acid sequence
binding protein
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JP2023528207A5 (enExample
Inventor
ヴァレリー ペリーヌ カラブロ
ニコロ リガモンティ
クララ ドンケ
アーニャ クリスティーナ シュレーゲル
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モレキュラー パートナーズ アクチェンゲゼルシャフト
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Publication of JP2023528207A publication Critical patent/JP2023528207A/ja
Publication of JP2023528207A5 publication Critical patent/JP2023528207A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2022568692A 2020-05-14 2021-05-14 組換えｃｄ４０結合タンパク質及びそれらの使用 Pending JP2023528207A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20174830 2020-05-14
EP20174830.8 2020-05-14
PCT/EP2021/062874 WO2021229076A1 (en) 2020-05-14 2021-05-14 Recombinant cd40 binding proteins and their use

Publications (2)

Publication Number Publication Date
JP2023528207A true JP2023528207A (ja) 2023-07-04
JP2023528207A5 JP2023528207A5 (enExample) 2024-05-09

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JP2022568692A Pending JP2023528207A (ja) 2020-05-14 2021-05-14 組換えｃｄ４０結合タンパク質及びそれらの使用

Country Status (7)

Country Link
US (1) US20240279309A1 (enExample)
EP (1) EP4149960A1 (enExample)
JP (1) JP2023528207A (enExample)
CN (1) CN115996945A (enExample)
AU (1) AU2021271131A1 (enExample)
CA (1) CA3178478A1 (enExample)
WO (1) WO2021229076A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020402581A1 (en) 2019-12-11 2022-06-23 Molecular Partners Ag Designed ankyrin repeat domains with altered surface residues
IL298168A (en) 2020-05-14 2023-01-01 Molecular Partners Ag Multispecific proteins
US11981710B2 (en) 2020-08-18 2024-05-14 Athebio Ag N-terminal capping modules of ankyrin repeat domains
EP3957649A1 (en) 2020-08-18 2022-02-23 Athebio AG Improved n-terminal capping modules of ankyrin repeat domains
WO2022190016A1 (en) 2021-03-09 2022-09-15 Molecular Partners Ag Novel darpin based multi-specific t-cell engagers
WO2023021050A1 (en) * 2021-08-17 2023-02-23 Athebio Ag Variants of ankyrin repeat domains
EP4137508A1 (en) * 2021-08-17 2023-02-22 Athebio AG Variants of ankyrin repeat domains
EP4724473A1 (en) * 2023-06-06 2026-04-15 Molecular Partners AG Recombinant cd47 binding proteins and their use
WO2025146490A1 (en) * 2024-01-05 2025-07-10 Molecular Partners Ag Recombinant cd117 binding proteins and their use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1332209B1 (en) 2000-09-08 2009-11-11 Universität Zürich Collections of repeat proteins comprising repeat modules
AR039067A1 (es) 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
CA2700391A1 (en) 2007-09-24 2009-04-02 University Of Zuerich Designed armadillo repeat proteins
WO2011040972A1 (en) 2009-10-02 2011-04-07 Ludwig Institute For Cancer Research Ltd. Anti-fibroblast activation protein antibodies and methods and uses thereof
EP3514169B1 (en) * 2010-11-26 2024-03-06 Molecular Partners AG Designed repeat proteins binding to serum albumin
EP2738180A1 (en) * 2012-11-30 2014-06-04 Molecular Partners AG Binding proteins comprising at least two binding domains against HER2.
US11453708B2 (en) * 2013-05-31 2022-09-27 Molecular Partners Ag Designed ankyrin repeat proteins binding to hepatocyte growth factor
US9458211B1 (en) * 2015-04-02 2016-10-04 Molecular Partners Ag Recombinant proteins that simultaneously bind HGF, VEGF-A and serum albumin, comprising ankyrin repeat domains
MY196882A (en) * 2016-09-22 2023-05-08 Molecular Partners Ag Recombinant binding proteins and their use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FIEDLER, ULRIKE ET AL.: ""Abstract 4552: Tumor-restricted immune modulation by multispecific molecules from the DARPin toolb", CANCER RESEARCH, vol. Vol. 78, No. 13_Supplement, JPN6025017554, 2018, pages 4552 - 4552, ISSN: 0005587412 *
LEVITSKY, VICTOR ET AL.: ""Abstract B026: Development of tumor-targeted agonistic Immunomodulators using the DARPin technolog", CANCER IMMUNOLOGY RESEARCH, vol. 7, JPN6025017552, 2019, pages 026 - 026, ISSN: 0005587411 *
LI, JUNAN ET AL.: ""Ankyrin Repeat: A Unique Motif Mediating Protein−Protein Interactions"", BIOCHEMISTRY, vol. 45, no. 51, JPN6025017551, 2006, pages 15168 - 15178, ISSN: 0005587413 *
RIGAMONTI, NICOLO ET AL.: ""Abstract 3251: Fibroblast activation protein (FAP)-selective delivery of CD40 agonistic DARPinmole", CANCER RESEARCH, vol. Vol. 79, No. 13_Supplement, JPN6025017553, 2019, pages 3251 - 3251, ISSN: 0005587410 *

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Publication number Publication date
US20240279309A1 (en) 2024-08-22
AU2021271131A1 (en) 2022-12-15
EP4149960A1 (en) 2023-03-22
CA3178478A1 (en) 2021-11-18
WO2021229076A1 (en) 2021-11-18
CN115996945A (zh) 2023-04-21

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