JP2023527621A - 哺乳類におけるキメラ抗原受容体媒介性免疫応答を刺激するための方法における使用のための、ｐｄ－ｌ１および／またはｐｄ－ｌ２を含む標的化モジュール - Google Patents

哺乳類におけるキメラ抗原受容体媒介性免疫応答を刺激するための方法における使用のための、ｐｄ－ｌ１および／またはｐｄ－ｌ２を含む標的化モジュール Download PDF

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JP2023527621A
JP2023527621A JP2022555742A JP2022555742A JP2023527621A JP 2023527621 A JP2023527621 A JP 2023527621A JP 2022555742 A JP2022555742 A JP 2022555742A JP 2022555742 A JP2022555742 A JP 2022555742A JP 2023527621 A JP2023527621 A JP 2023527621A
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targeting module
chimeric antigen
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エーニンガー・アルミン
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Avencell Europe GmbH
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4274—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K2239/23—On/off switch
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JP2022555742A 2020-03-16 2021-03-16 哺乳類におけるキメラ抗原受容体媒介性免疫応答を刺激するための方法における使用のための、ｐｄ－ｌ１および／またはｐｄ－ｌ２を含む標的化モジュール Pending JP2023527621A (ja)

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EP20163257.7 2020-03-16
EP20163257.7A EP3881866A1 (en) 2020-03-16 2020-03-16 A targeting module comprising pd-l1 and/or pd-l2 for use in a method for stimulating a chimeric antigen receptor mediated response in a mammal
PCT/EP2021/056625 WO2021185807A1 (en) 2020-03-16 2021-03-16 A targeting module comprising pd-l1 and/or pd-l2 for use in a method for stimulating a chimeric antigen receptor mediated immune response in a mammal

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JP2023527621A true JP2023527621A (ja) 2023-06-30
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CA (1) CA3170250A1 (https=)
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WO2021234006A1 (en) * 2020-05-20 2021-11-25 Miltenyi Biotec B.V. & Co. KG Compositions and methods for treating cancer expressing cd90 and cd326
WO2025219955A1 (en) * 2024-04-17 2025-10-23 BioNTech SE Soluble tcrs and methods of use thereof

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JP2012511329A (ja) * 2008-12-09 2012-05-24 ジェネンテック， インコーポレイテッド 抗ｐｄ−ｌ１抗体およびｔ細胞機能を増強するためのそれらの使用
JP2016533174A (ja) * 2013-10-15 2016-10-27 ザ カリフォルニア インスティテュート フォー バイオメディカル リサーチ ペプチドキメラ抗原受容体ｔ細胞スイッチおよびその使用
WO2018224660A1 (en) * 2017-06-09 2018-12-13 Armin Ehninger Targeting modules for universal chimeric antigen receptor expressing immune cells and use in the treatment of cancer infections and autoimmune disorders

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US9233125B2 (en) 2010-12-14 2016-01-12 University Of Maryland, Baltimore Universal anti-tag chimeric antigen receptor-expressing T cells and methods of treating cancer
WO2013044225A1 (en) 2011-09-22 2013-03-28 The Trustees Of The University Of Pennsylvania A universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens
EP2990416B1 (en) 2014-08-29 2018-06-20 GEMoaB Monoclonals GmbH Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders
US11091546B2 (en) * 2015-04-15 2021-08-17 The Scripps Research Institute Optimized PNE-based chimeric receptor T cell switches and uses thereof
EP3315511A1 (en) * 2016-10-29 2018-05-02 Miltenyi Biotec GmbH Adapter chimeric antigen receptor expressing cells for targeting of multiple antigens
DK3592769T3 (da) * 2017-03-09 2024-08-12 Genmab As Antistoffer mod pd-l1

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JP2012511329A (ja) * 2008-12-09 2012-05-24 ジェネンテック， インコーポレイテッド 抗ｐｄ−ｌ１抗体およびｔ細胞機能を増強するためのそれらの使用
JP2016533174A (ja) * 2013-10-15 2016-10-27 ザ カリフォルニア インスティテュート フォー バイオメディカル リサーチ ペプチドキメラ抗原受容体ｔ細胞スイッチおよびその使用
WO2018224660A1 (en) * 2017-06-09 2018-12-13 Armin Ehninger Targeting modules for universal chimeric antigen receptor expressing immune cells and use in the treatment of cancer infections and autoimmune disorders

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EP3881866A1 (en) 2021-09-22
AU2021237694A1 (en) 2022-09-22
EP4121107A1 (en) 2023-01-25
US20230183351A1 (en) 2023-06-15
CA3170250A1 (en) 2021-09-23
WO2021185807A1 (en) 2021-09-23

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